anti-GJB2 (GJB2) 抗体产品概述

Full name:
anti-Gap Junction Protein, beta 2, 26kDa 抗体 (GJB2)
在www.antibodies-online.cn可供88 Gap Junction Protein, beta 2, 26kDa (GJB2) 抗体的20不同的供货商。 再加上,我们可以发GJB2 试剂盒 (32)GJB2 蛋白 (4)和数多这个蛋白质的别的产品。 总共129 GJB2产品已列进来了。
别名:
AI325222, Cnx26, connexin-26, CX26, CXN-26, DFNA3, DFNA3A, DFNB1, DFNB1A, Gjb-2, GJB2, HID, KID, MGC53062, NSRD1, PPK

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引用最多的anti-GJB2 抗体

  1. Cow (Bovine) Polyclonal GJB2 Primary Antibody for WB - ABIN2774858 : Ulfig: Expression of connexin 26 in the ganglionic eminence of preterm infants after bleedings. in Neuroscience research 2004 (PubMed)

  2. Mouse (Murine) Polyclonal GJB2 Primary Antibody for ELISA, WB - ABIN190896 : Djalilian, McGaughey, Patel, Seo, Yang, Cheng, Tomic, Sinha, Ishida-Yamamoto, Segre: Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. in The Journal of clinical investigation 2006 (PubMed)

更多抗GJB2的相互作用对抗体

Xenopus laevis Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. Using reconstituted hemichannels in a liposome-based transport-specific fractionation assay, we confirmed that homomeric Cx26 and Cx32 (显示 GJB1 抗体) and heteromeric Cx26/Cx32 (显示 GJB1 抗体) are permeable to GSH and other endogenous reductants.

Mouse (Murine) Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. In connexin knock-outs, Cx26 and Cx30 (显示 GJB6 抗体), inner hair cells remained stuck at a prehearing stage of development.

  2. Reduced Cx26 expression in the mature mouse cochlea may increase susceptibility to noise-induced hearing loss .

  3. mir (显示 MLXIP 抗体)-27a was identified as an apoptotic molecule that participates in Cx26 knockout-induced apoptosis in the cochlear sensory epithelium of mice by downregulating sgk1 (显示 SGK1 抗体) expression

  4. Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

  5. Cx26-mediated intercellular communication is required for cochlear development and that deficiency of Cx26 can impair miRNA-mediated intercellular genetic communication in the cochlea, which may lead to cochlear developmental disorders

  6. presence of Cx30 (显示 GJB6 抗体) in the cochlea does not compensate for Cx26 loss, and the absence of both connexins from vestibular sensory epithelia is no more injurious than the absence of one of them

  7. Reciprocal positive regulation between Cx26 and PI3K/Akt (显示 AKT1 抗体) pathway confers acquired gefitinib resistance in non-small-cell lung carcinoma cells by promoting epithelial mesenchymal transition via a gap-junctional communication-independent manner.

  8. The inserting reconstituted gap junction Cx26 liposomes into the oocytes allowed the demonstration of intracellular/extracellular Ca(2 (显示 CA2 抗体)+)-regulated hemi-channel activities.

  9. Study used an inducible gene knockout technique to delete Cx26 expression in the cochlea after birth, results suggest that Cx26 deficiency may impair active cochlear amplification leading to late-onset hearing loss

  10. These results suggest that low levels of Cx26 expression throughout pregnancy and lactation, and not the physiological surge in Cx26, is sufficient for normal gland development and function.

Human Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. WFS1 (显示 WFS1 抗体) and GJB2 mutations were identified in eight of 74 cases of Low-Frequency Sensorineural Hearing Loss. Four cases had heterozygous WFS1 (显示 WFS1 抗体) mutations; one had a heterozygous WFS1 (显示 WFS1 抗体) mutation and a heterozygous GJB2 mutation; and three cases had biallelic GJB2 mutations. Three cases with WFS1 (显示 WFS1 抗体) mutations were sporadic; two of them were confirmed to be caused by a de novo mutation based on the genetic analysis of their parents.

  2. results demonstrate that 19.2% patients with nonsyndromic deafness were caused by mutations in three common deafness genes (GJB2, SLC26A4 (显示 SLC26A4 抗体) and 12S rRNA) in our northern China patient group

  3. GJB2-related deafness leads to significantly better cochlear implantation outcomes when compared with acquired deafness caused by environmental etiologies. However, GJB2 mutation is not associated with a significantly better prognosis when compared with those whose deafness results from either nonsyndromic hearing loss of unknown origin or other types of genetic mutations in the absence of other neurologic deficits.

  4. expression of Cx26 (also known as GJB2) in HeLa cells specifically enhances cell motility in scrape wounding and sparse culture models.

  5. Results found that the contribution of the GJB2 gene pathogenic variants to hearing impairment in the population of the Sakha Republic was the highest among all of the regions of Asia studied previously suggesting that extensive accumulation of the c.-23+1G>A pathogenic variant in the indigenous Yakut population may indicate the possible selective advantage of the c.-23+1G>A carriers living in the subarctic climate.

  6. Reduced expression of Cx26 and Cx43 (显示 GJA1 抗体) is implicated in the pathophysiology of colonic dysmotility in the aganglionic bowel as well as, in the case of Cx26, the ganglionic bowel in Hirschsprung's disease.

  7. These findings suggest that Cx26 mutants that promote cell death or exert transdominant effects on other connexins in keratinocytes will lead to skin diseases and hearing loss

  8. Cx26-Asp50Asn with the second-site mutations identified in the patient displayed no formation of gap junction channel plaques. We argue that the second-site mutations independently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative effect of the p.Asp50Asn mutation

  9. the role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46 (显示 GJA3 抗体), and Cx50 (显示 GJA8 抗体).

  10. Cx26 and Cx30 (显示 GJB6 抗体) proteins thus seem not to be co-expressed but to form closely associated assemblies of gap junction plaques.

Cow (Bovine) Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32 (显示 GJB1 抗体), and Cx43 (显示 GJA1 抗体)

GJB2 抗原简介

Antigen Summary

This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

Alternative names and synonyms associated with GJB2

  • gap junction protein, beta 2, 26kDa (gjb2) 抗体
  • gap junction protein, beta 2, 26kDa (GJB2) 抗体
  • gap junction protein, beta 2 (Gjb2) 抗体
  • AI325222 抗体
  • Cnx26 抗体
  • connexin-26 抗体
  • CX26 抗体
  • CXN-26 抗体
  • DFNA3 抗体
  • DFNA3A 抗体
  • DFNB1 抗体
  • DFNB1A 抗体
  • Gjb-2 抗体
  • GJB2 抗体
  • HID 抗体
  • KID 抗体
  • MGC53062 抗体
  • NSRD1 抗体
  • PPK 抗体

Protein level used designations for GJB2

gap junction protein, beta 2, 26kDa , connexin 26 , connexin 29 , gap junction membrane channel protein beta 6 , gap junction protein, beta 2, 26kDa (connexin 26) , connexin-26 , gap junction beta-2 protein , gap junction membrane channel protein beta 2 , gap junction channel protein connexin 26 , connexin26 , gap junction protein beta 2 , connexin 26 protein , cx26

GENE ID SPECIES
380170 Xenopus laevis
467220 Pan troglodytes
14619 Mus musculus
394266 Rattus norvegicus
100379528 Cavia porcellus
2706 Homo sapiens
403570 Canis lupus familiaris
407154 Bos taurus
443345 Ovis aries
704224 Macaca mulatta
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