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General TSC2 ELISA Kit for Competition ELISA - ABIN1140792
Feruglio, Trøseid, Damås, Kvale, Dyrhol-Riise: Soluble markers of the Toll-like receptor 4 pathway differentiate between active and latent tuberculosis and are associated with treatment responses. in PLoS ONE 2013
This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (显示 TP53 ELISA试剂盒) during tumorigenesis.
These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.
In our series, consistent with other studies, TSC2 mutations were associated with a more severe phenotypic spectrum than TSC1 (显示 TSC1 ELISA试剂盒) mutations. This is the first study that sought to characterize the molecular spectrum of Brazilian individuals with tuberous sclerosis
Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC (显示 MYC ELISA试剂盒)-amplified model cell line
This case provides evidence for a unique TSC2 mutation that resulted in an atypical clinical presentation and indicates potential shortcomings of the current diagnostic criteria for TSC (显示 SLC12A3 ELISA试剂盒). These findings may have implications for genetic counseling and screening.
we report a pathogenic TSC2 variant, c.1864C>T, p.(Arg622Trp), associated with a mild phenotype, with most carriers meeting fewer than two major clinical diagnostic criteria for TSC (显示 SLC12A3 ELISA试剂盒). This finding has significant implications for counseling patients regarding prognosis.
The results highlight a new role of TSC2 in protecting glioblastoma against photodynamic therapy-induced cell death, and TSC2 and YWHAZ (显示 YWHAZ ELISA试剂盒) as new RIP3 (显示 RIPK3 ELISA试剂盒) partners.
Study provides new information regarding cerebellar lesions in tuberous sclerosis complex: cerebellar lesions are significantly much more frequent in patients with TSC2 mutations than TSC1 (显示 TSC1 ELISA试剂盒) mutations or patients with no mutation identified, and Crus II is the most frequent location of cerebellar lesions.
Two pathogenic mutations in TSC1 (显示 TSC1 ELISA试剂盒) and one in TSC2 genes were identified in patients with tuberous sclerosis complex; the patient with TSC2 mutation manifested a more severe clinical phenotype
Novel missense mutation in the exon 19 of the TSC2 gene is associated with tuberous sclerosis.
our findings suggest the significance of previously undocumented mutation-dependent mTOR (显示 FRAP1 ELISA试剂盒) hyperactivation and frequent TSC1 (显示 TSC1 ELISA试剂盒)/2 mutations in HBV-associated HCCs (显示 HCCS ELISA试剂盒). They define a molecular subset of HCC (显示 FAM126A ELISA试剂盒) having genetic aberrations in mTOR (显示 FRAP1 ELISA试剂盒) signalling, with potential significance of effective specific drug therapy.
Mutation in TSC2 is associated with lymphangioleiomyomatosis.
Tsc2-mTOR (显示 FRAP1 ELISA试剂盒) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.
TSC1 (显示 TSC1 ELISA试剂盒)/TSC2 complex upregulation of OPN (显示 SPP1 ELISA试剂盒) expression is mediated by transcription factor SOX9 (显示 SOX9 ELISA试剂盒) in an mTOR (显示 FRAP1 ELISA试剂盒)-independent manner. Moreover, ablation of OPN (显示 SPP1 ELISA试剂盒) by deficient TSC1 (显示 TSC1 ELISA试剂盒)/TSC2 complex contributed to inactivation of AKT (显示 AKT1 ELISA试剂盒) in TSC (显示 SLC12A3 ELISA试剂盒) cells
Rheb (显示 RHEB ELISA试剂盒) and TSC2 have roles in the mechanical activation of mTOR (显示 FRAP1 ELISA试剂盒) signaling
this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.
Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.
Formation of ROS (显示 ROS1 ELISA试剂盒) and activity of NADPH (显示 FDXR ELISA试剂盒) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.
Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (显示 HDAC1 ELISA试剂盒) and HdAC2 (显示 HDAC2 ELISA试剂盒), tuberous sclerosis complex 2 (TSC2), and mTOR (显示 FRAP1 ELISA试剂盒) srine-threonine kinases (mTOR (显示 FRAP1 ELISA试剂盒)).
autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.
PAK2 (显示 PAK2 ELISA试剂盒) is a direct effector of TSC1 (显示 TSC1 ELISA试剂盒)-TSC2-RHEB (显示 RHEB ELISA试剂盒) signaling and a new target for rational drug therapy in TSC (显示 SLC12A3 ELISA试剂盒).
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 ELISA试剂盒)/ERK (显示 MAPK1 ELISA试剂盒)/TSC2/mTOR (显示 FRAP1 ELISA试剂盒) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (显示 FRAP1 ELISA试剂盒) and ribosomal protein S6 (显示 RPS6 ELISA试剂盒) kinase (显示 RPS6KB1 ELISA试剂盒) signaling in an AKT (显示 AKT1 ELISA试剂盒)-independent manner
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
tuberous sclerosis complex 2 (TSC2)
, tuberous sclerosis 2
, tuberous sclerosis 2 protein
, tuberous sclerosis 2 protein homolog
, renal carcinoma
, tuberous sclerosis 2 homolog protein