TSC2 (TSC2) ELISA试剂盒产品概述

Full name:
Tuberous Sclerosis 2 ELISA试剂盒 (TSC2)
在www.antibodies-online.cn可供14 Tuberous Sclerosis 2 (TSC2) ELISA试剂盒的8不同的供货商。 再加上,我们可以发TSC2 抗体 (746)和数多这个蛋白质的别的产品。 总共783 TSC2产品已列进来了。
别名:
fc16b02, LAM, Nafld, Rc, Tcs2, TSC2, TSC4, tuberin, wu:fc16b02

引用最多的TSC2 ELISA试剂盒

  1. General TSC2 ELISA Kit for Competition ELISA - ABIN1140792 : Feruglio, Trøseid, Damås, Kvale, Dyrhol-Riise: Soluble markers of the Toll-like receptor 4 pathway differentiate between active and latent tuberculosis and are associated with treatment responses. in PLoS ONE 2013 (PubMed)

适于 TSC2 相互作用对的更多 ELISA 试剂盒

Zebrafish Tuberous Sclerosis 2 (TSC2) interaction partners

  1. This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (显示 TP53 ELISA试剂盒) during tumorigenesis.

  2. These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.

Human Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Novel missense mutation in the exon 19 of the TSC2 gene is associated with tuberous sclerosis.

  2. our findings suggest the significance of previously undocumented mutation-dependent mTOR (显示 FRAP1 ELISA试剂盒) hyperactivation and frequent TSC1 (显示 TSC1 ELISA试剂盒)/2 mutations in HBV-associated HCCs (显示 HCCS ELISA试剂盒). They define a molecular subset of HCC (显示 FAM126A ELISA试剂盒) having genetic aberrations in mTOR (显示 FRAP1 ELISA试剂盒) signalling, with potential significance of effective specific drug therapy.

  3. Mutation in TSC2 is associated with lymphangioleiomyomatosis.

  4. Results show that tuberous sclerosis complex disease segregates with a silent substitution in TSC2, c.4149C>T, p.(Ser1838Ser), which leads to the formation of an active donor splice site, resulting in three shorter alternatively spliced transcripts with premature stop codons.

  5. Clinical whole exome sequencing of blood and tumor samples con (显示 DISP1 ELISA试剂盒) fi rmed the diagnosis of methylmalonic acidemia and revealed two somatic inactivating mutations in TSC2, suggesting the potential consideration of an mTOR (显示 FRAP1 ELISA试剂盒) inhibitor in the event of tumor recurrence.

  6. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  7. The mTOR (显示 FRAP1 ELISA试剂盒)-dependent, epithelial phenotype of TSC (显示 SLC12A3 ELISA试剂盒) astrocytes suggests TSC1 (显示 TSC1 ELISA试剂盒)/2 and mTOR (显示 FRAP1 ELISA试剂盒) tune the phosphorylation level of catenin delta-1 (显示 CTNND1 ELISA试剂盒) by controlling PKCe (显示 PRKCE ELISA试剂盒) activity, thereby regulating the mesenchymal-epithelial-transition (MET)

  8. TSC2 mutations leading to severe tuberous sclerosis in Chinese children.

  9. Our results indicate that TSC2 and less commonly TSC1 (显示 TSC1 ELISA试剂盒) alterations are the primary essential driver event in angiomyolipoma/Lymphangioleiomyomatosis, whereas other somatic mutations are rare and likely do not contribute to tumor development.

  10. These results suggested that TSC2 heterozygosity caused neurological malformations in primitive neural stem cells, indicating that its heterozygosity might be sufficient for the development of neurological abnormalities in patients.

Mouse (Murine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Tsc2-mTOR (显示 FRAP1 ELISA试剂盒) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.

  2. TSC1 (显示 TSC1 ELISA试剂盒)/TSC2 complex upregulation of OPN (显示 SPP1 ELISA试剂盒) expression is mediated by transcription factor SOX9 (显示 SOX9 ELISA试剂盒) in an mTOR (显示 FRAP1 ELISA试剂盒)-independent manner. Moreover, ablation of OPN (显示 SPP1 ELISA试剂盒) by deficient TSC1 (显示 TSC1 ELISA试剂盒)/TSC2 complex contributed to inactivation of AKT (显示 AKT1 ELISA试剂盒) in TSC (显示 SLC12A3 ELISA试剂盒) cells

  3. Rheb (显示 RHEB ELISA试剂盒) and TSC2 have roles in the mechanical activation of mTOR (显示 FRAP1 ELISA试剂盒) signaling

  4. this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis

  5. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  6. Repression of TSC1 (显示 TSC1 PLURAL_@12100@)/TSC2 mediated by MeCP2 (显示 MECP2 PLURAL_@12100@) regulates human embryo lung fibroblast cell differentiation and proliferation.

  7. Formation of ROS (显示 ROS1 ELISA试剂盒) and activity of NADPH (显示 FDXR ELISA试剂盒) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.

  8. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (显示 HDAC1 ELISA试剂盒) and HdAC2 (显示 HDAC2 ELISA试剂盒), tuberous sclerosis complex 2 (TSC2), and mTOR (显示 FRAP1 ELISA试剂盒) srine-threonine kinases (mTOR (显示 FRAP1 ELISA试剂盒)).

  9. autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.

  10. PAK2 (显示 PAK2 ELISA试剂盒) is a direct effector of TSC1 (显示 TSC1 ELISA试剂盒)-TSC2-RHEB (显示 RHEB ELISA试剂盒) signaling and a new target for rational drug therapy in TSC (显示 SLC12A3 ELISA试剂盒).

Pig (Porcine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 ELISA试剂盒)/ERK (显示 MAPK1 ELISA试剂盒)/TSC2/mTOR (显示 FRAP1 ELISA试剂盒) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

Cow (Bovine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (显示 FRAP1 ELISA试剂盒) and ribosomal protein S6 (显示 RPS6 ELISA试剂盒) kinase (显示 RPS6KB1 ELISA试剂盒) signaling in an AKT (显示 AKT1 ELISA试剂盒)-independent manner

TSC2 抗原简介

Antigen Summary

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with TSC2

  • tuberous sclerosis 2 (TSC2) Elisa Kit
  • tuberous sclerosis complex 2 (TSC2) (AaeL_AAEL007712) Elisa Kit
  • tuberous sclerosis 2 (tsc2) Elisa Kit
  • tuberous sclerosis 2 (PGTG_00159) Elisa Kit
  • tuberous sclerosis 2 (Tsc2) Elisa Kit
  • fc16b02 Elisa Kit
  • LAM Elisa Kit
  • Nafld Elisa Kit
  • Rc Elisa Kit
  • Tcs2 Elisa Kit
  • TSC2 Elisa Kit
  • TSC4 Elisa Kit
  • tuberin Elisa Kit
  • wu:fc16b02 Elisa Kit

Protein level used designations for TSC2

tuberous sclerosis complex 2 (TSC2) , tuberous sclerosis 2 , tuberin-like , tuberin , tuberous sclerosis 2 protein , tuberous sclerosis 2 protein homolog , renal carcinoma , tuberous sclerosis 2 homolog protein

GENE ID SPECIES
100065679 Equus caballus
5569538 Aedes aegypti
468086 Pan troglodytes
567524 Danio rerio
694965 Macaca mulatta
10528144 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100170546 Xenopus (Silurana) tropicalis
100390664 Callithrix jacchus
7249 Homo sapiens
22084 Mus musculus
24855 Rattus norvegicus
479883 Canis lupus familiaris
100505408 Sus scrofa
504985 Bos taurus
416552 Gallus gallus
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