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anti-RHEB (RHEB) 抗体产品概述

Full name:
anti-Ras Homolog Enriched in Brain 抗体 (RHEB)
在www.antibodies-online.cn可供135 Ras Homolog Enriched in Brain (RHEB) 抗体的24不同的供货商。 再加上,我们可以发RHEB 蛋白 (15)和数多这个蛋白质的别的产品。 总共161 RHEB产品已列进来了。
别名:
im:7161941, RHEB, RHEB2, zgc:153231

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引用最多的anti-RHEB 抗体

  1. Human Polyclonal RHEB Primary Antibody for EIA, IHC (p) - ABIN500597 : Yee, Worley: Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. in Molecular and cellular biology 1997 (PubMed)
    Show all 4 references for ABIN500597

  2. Human Polyclonal RHEB Primary Antibody for EIA, IHC (p) - ABIN954537 : Zheng, Liu, Liu, Li, Yu, Luo: Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells. in Cancer letters 2010 (PubMed)
    Show all 3 references for ABIN954537

  3. Human Polyclonal RHEB Primary Antibody for WB - ABIN2786819 : Eom, Han, Yi, Shin, Cui, Park: RHEB expression in fibroadenomas of the breast. in Pathology international 2008 (PubMed)

  4. Human Monoclonal RHEB Primary Antibody for ELISA, WB - ABIN519784 : Menon, Dibble, Talbott, Hoxhaj, Valvezan, Takahashi, Cantley, Manning: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. in Cell 2014 (PubMed)

更多抗RHEB的相互作用对抗体

Human Ras Homolog Enriched in Brain (RHEB) interaction partners

  1. By interfering with TSC (显示 SLC12A3 抗体)-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC (显示 SLC12A3 抗体). Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 (显示 TSC2 抗体) from lysosomes and activation of mTORC1.

  2. Data show that Rheb/p27 (显示 PAK2 抗体) axis induces autophagy-dependent cancer cell survival under stress conditions.

  3. Mutations in the TSC2 (显示 TSC2 抗体)-RHEB-mTOR (显示 FRAP1 抗体) signaling axis may lead to a loss of inhibitory inputs thus conferring a survival advantage to a dividing tumor cell.

  4. Activation of CNTF (显示 CNTF 抗体)/CNTFRalpha (显示 CNTFR 抗体) signaling pathway by hRheb(S16H) transduction of dopaminergic neurons

  5. RGS10 (显示 RGS10 抗体) could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP (显示 AK3 抗体) from Rheb in ovarian cancer cells.

  6. In TSC2 (显示 TSC2 抗体)-deficient angiomyolipoma patient cells, IRF7 (显示 IRF7 抗体) is a pivotal factor in the Rheb/mTOR (显示 FRAP1 抗体) pathway.

  7. These results establish CAD (显示 CAD 抗体) as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1 (显示 RHEBL1 抗体))

  8. In vitro data indicated that miR (显示 MLXIP 抗体)-155 suppressed the macrophage-mediated bacterial phagocytosis and intracellular killing of Pseudomonas aeruginosa by targeting Rheb (Ras homolog enriched in brain).

  9. Data indicate that Rheb G63A stimulated phosphorylation of the mTORC1 substrate p70S6 kinase more strongly than wild-type, thus offering a new tool for mammalian target of rapamycin (mTOR (显示 FRAP1 抗体)) signaling.

  10. study defines Rheb as a novel physiological regulator of BACE1 (显示 BACE 抗体) levels and Abeta (显示 APP 抗体) generation, and the Rheb-BACE1 (显示 BACE 抗体) circuitry may have a role in brain biology and disease.

Mouse (Murine) Ras Homolog Enriched in Brain (RHEB) interaction partners

  1. EAAT4 (显示 SLC1A6 抗体) was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt (显示 AKT1 抗体) was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt (显示 AKT1 抗体) may be related to the downregulation of EAAT4 (显示 SLC1A6 抗体); Rheb1 knockout decreased EAAT4 (显示 SLC1A6 抗体) currents and slowed down the kinetics of AMPA (显示 GRIA3 抗体) currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells

  2. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  3. Rheb activation disrupts neuronal spine synapse formation via syntenin (显示 SDCBP 抗体) accumulation in tuberous sclerosis complex.

  4. We conclude that in contrast to TORC1 (显示 CRTC1 抗体) hyper-activity, cognitive function is not very sensitive to sustained and specific down-regulation of TORC1 (显示 CRTC1 抗体) activity.

  5. Rheb protein was mainly detected in apoptotic retinal ganglion cells following light injury.

  6. PDK4 (显示 PDK4 抗体) promotes tumorigenesis through activation of the CREB (显示 CREB1 抗体)-RHEB-mTORC1 signaling cascade.

  7. The small GTPase (显示 RACGAP1 抗体) Rheb is required for spermatogenesis but not oogenesis.

  8. The paper proposed a novel pathway/mechanism involving Rheb/mTORC1/S6K (显示 RPS6KB1 抗体) signaling to explain how C2-ceramide impairs insulin (显示 INS 抗体) signaling via Akt (显示 AKT1 抗体) phosphorylation.

  9. whereas rapid adaptation in mTORC1 activity requires Rheb, a second Rheb-independent activation mechanism exists that contributes to cell cycle progression.

  10. miR (显示 MLXIP 抗体)-155 bound to the 3'-untranslated region of Ras homologue enriched in brain (Rheb), a negative regulator of autophagy, accelerated the process of autophagy and sequential killing of intracellular mycobacteria by suppressing Rheb expression.

RHEB 抗原简介

Antigen Summary

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.

Alternative names and synonyms associated with RHEB

  • Ras homolog enriched in brain (RHEB) 抗体
  • Ras homolog enriched in brain (rheb) 抗体
  • ras homolog enriched in brain (rheb) 抗体
  • Ras homolog enriched in brain (Rheb) 抗体
  • im:7161941 抗体
  • RHEB 抗体
  • RHEB2 抗体
  • zgc:153231 抗体

Protein level used designations for RHEB

Ras homolog enriched in brain , RAS-homolog enriched in brain , ras homolog enriched in brain , GTP-binding protein rheb , GTP-binding protein Rheb , Ras homolog enriched in brain 2

GENE ID SPECIES
475545 Canis lupus familiaris
548676 Xenopus (Silurana) tropicalis
767781 Danio rerio
100528708 Ictalurus punctatus
6009 Homo sapiens
19744 Mus musculus
26954 Rattus norvegicus
420434 Gallus gallus
528204 Bos taurus
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