FLT3 (FLT3) ELISA试剂盒产品概述

Full name:
Fms-Related tyrosine Kinase 3 ELISA试剂盒 (FLT3)
在www.antibodies-online.cn可供40 Fms-Related tyrosine Kinase 3 (FLT3) ELISA试剂盒的14不同的供货商。 再加上,我们可以发FLT3 抗体 (366)FLT3 蛋白 (28)和数多这个蛋白质的别的产品。 总共445 FLT3产品已列进来了。
别名:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl

适于 FLT3 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. the Hoxa9 (显示 HOXA9 ELISA试剂盒)- and Meis1 (显示 MEIS1 ELISA试剂盒)-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML (显示 RUNX1 ELISA试剂盒) pathology.

  2. lineage-specific STAT5 (显示 STAT5A ELISA试剂盒) activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype in mice

  3. DOCK2 (显示 DOCK2 ELISA试剂盒) is a potential therapeutic target for novel AML (显示 RUNX1 ELISA试剂盒) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  4. Used a genetic model to determine whether miR (显示 MLXIP ELISA试剂盒)-155 influences the development of FLT3-ITD-induced myeloproliferative disease. miR (显示 MLXIP ELISA试剂盒)-155 promotes FLT3-ITD-induced myeloid expansion in the bone marrow, spleen, and peripheral blood. Mechanistically, miR (显示 MLXIP ELISA试剂盒)-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by reducing the growth-inhibitory effects of the interferon (显示 IFNA ELISA试剂盒) response.

  5. Overexpression of Abl (显示 ABL1 ELISA试剂盒)-related gene tyrosine kinase (显示 TYRO3 ELISA试剂盒) ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.

  6. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  7. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 (显示 PBX1 ELISA试剂盒) axis

  8. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (显示 TYRO3 ELISA试剂盒) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  9. DNMT3A (显示 DNMT3A ELISA试剂盒) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (显示 RUNX1 ELISA试剂盒).

  10. murine Fms-like tyrosine kinase 3 (Flt3) ligand (显示 FLT3LG ELISA试剂盒) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (显示 SLC11A1 ELISA试剂盒)) infection in vitro.

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. Collectively, we have developed a novel targeted therapeutic strategy, using FLT3L (显示 FLT3LG ELISA试剂盒)-guided miR (显示 MLXIP ELISA试剂盒)-150-based nanoparticles, to treat FLT3-overexpressing AML (显示 RUNX1 ELISA试剂盒) with high efficacy and minimal side effects.

  2. Y842 is critical for FLT3-mediated RAS/ERK (显示 EPHB2 ELISA试剂盒) signaling and cellular transformation.

  3. value of FLT3-ITD allelic ratio in AML (显示 RUNX1 ELISA试剂盒) in risk assessment and evaluating prognosis

  4. DOCK2 (显示 DOCK2 ELISA试剂盒) is a potential therapeutic target for novel AML (显示 RUNX1 ELISA试剂盒) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  5. Gedatolisib significantly extended survival of mice in a sorafenib-resistant acute myeloid leukemia (显示 BCL11A ELISA试剂盒) (AML (显示 RUNX1 ELISA试剂盒)) patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K (显示 PIK3CA ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) pathway in FLT3-ITD-dependent AML (显示 RUNX1 ELISA试剂盒) results in resistance to drugs targeting FLT3.

  6. HHEX (显示 HHEX ELISA试剂盒) could replace RUNX1 (显示 RUNX1 ELISA试剂盒) in cooperating with FLT3-ITD to induce Acute myeloid leukemia (显示 BCL11A ELISA试剂盒) (AML (显示 RUNX1 ELISA试剂盒)).

  7. mutated FLT3-ITD and JAK2 (显示 JAK2 ELISA试剂盒) augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination.

  8. these data reveal a novel mechanism which regulates acute myeloid leukemia (显示 BCL11A ELISA试剂盒) cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting.

  9. MSI2 (显示 MSI2 ELISA试剂盒) and FLT3 are significantly co-regulated in human AML (显示 RUNX1 ELISA试剂盒)

  10. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

FLT3 抗原简介

Antigen Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3) Elisa Kit
  • FMS-like tyrosine kinase 3 (Flt3) Elisa Kit
  • fms-related tyrosine kinase 3 (Flt3) Elisa Kit
  • B230315G04 Elisa Kit
  • CD135 Elisa Kit
  • FLK-2 Elisa Kit
  • FLK2 Elisa Kit
  • Flt-3 Elisa Kit
  • FLT3 Elisa Kit
  • Ly72 Elisa Kit
  • STK1 Elisa Kit
  • wmfl Elisa Kit

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPECIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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