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myocardin is an essential component of the regulatory pathway for myocardial differentiation
several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells
Myocardin inhibits estrogen receptor alpha (显示 ESR1 ELISA试剂盒)-mediated proliferation of human breast cancer cells via regulating MicroRNA expression.
Key role for miR (显示 MLXIP ELISA试剂盒)-214 in modulation of MEF2C (显示 MEF2C ELISA试剂盒)-MYOCD-LMOD1 (显示 LMOD1 ELISA试剂盒) signaling.
Study demonstrates that myocardin indirectly down-regulates Cx43 (显示 GJA1 ELISA试剂盒) through its repressive action on miR (显示 MLXIP ELISA试剂盒)-206 to regulate vascular smooth muscle cell phenotypic switch.
These results have revealed the roles for atrogin-1 (显示 FBXO32 ELISA试剂盒) in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.
our study reveals that Ang II (显示 AGT ELISA试剂盒) downregulates miR (显示 MLXIP ELISA试剂盒)-145 to regulate Klf4 (显示 KLF4 ELISA试剂盒) and myocardin expression in HCASMCs under high glucose conditions. Ang II (显示 AGT ELISA试剂盒) plays a critical role in the regulation of miR (显示 MLXIP ELISA试剂盒)-145 under hyperglycemic conditions
Human expression data disclosed correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 (MRTF-B) was observed.
inhibition of GSK-3beta (显示 GSK3b ELISA试剂盒) reduces myocardin transcriptional activity, suggesting a role for GSK-3beta (显示 GSK3b ELISA试剂盒) in myocardin transcriptional activity and smooth muscle differentiation
STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF.
TMEM16A (显示 ANO1 ELISA试剂盒) and myocardin form a positive feedback loop that is disrupted by KLF5 (显示 KLF5 ELISA试剂盒) during Ang II (显示 AGT ELISA试剂盒)-induced vascular remodeling.
TNFalpha (显示 TNF ELISA试剂盒) differentially regulates myocardin expression and activity
TAZ (显示 TAZ ELISA试剂盒) and MyoC856 physically interact. SynergyTAZ and Myocardin (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells.
two MEF2 (显示 MEF2C ELISA试剂盒) sites in the enhancer function cooperatively due to bridging of the MEF2C (显示 MEF2C ELISA试剂盒)-bound sites by the SAP (显示 APCS ELISA试剂盒) domain-containing co-activator protein myocardin
c-Myb (显示 MYB ELISA试剂盒) regulates proliferation/differentiation of adventitial Sca1 (显示 ATXN1 ELISA试剂盒)+ vascular smooth muscle progenitor cells by transcriptional activation of myocardin.
Knock down of the serum response factor (SRF), which mediates many of the effects of myocardin, decreased cavin-1 but increased caveolin-1 and -2 mRNAs.
Cholesterol loading of vascular smooth muscle cells converts them to a macrophage-appearing state by downregulating the miR (显示 MLXIP ELISA试剂盒)-143/145-myocardin axis.
Our data illustrate a novel mechanism that connects MRTF-A (显示 MKL1 ELISA试剂盒) dependent histone H3K4 methylation to HSC (显示 FUT1 ELISA试剂盒) activation.
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 (显示 ATF6 ELISA试剂盒) signaling and myocardin expression.
Myocardin has a critical role in maintenance of vascular and visceral smooth muscle homeostasis during postnatal development
a moderate inhibition (e.g., normalization) of the activated MYOCD signaling in the diseased heart may be promising from a therapeutic point of view
MYOCD DeltaExon 11 may participate in modulating smooth muscle cell phenotype, potentially acting as a dominant-negative repressor of contraction-related genes.
Data show that forced myocd-A expression in the LVFW caused abnormal ECG.
Thrombin (显示 F2 ELISA试剂盒) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R ELISA试剂盒), RhoA (显示 RHOA ELISA试剂盒), and myocardin.
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, SRF co-factor protein (cardiac and smooth muscle)
, SRF cofactor protein
, basic SAP coiled-coil transcription activator 2
, transcription factor myocardin