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Rat (Rattus) DLG4 ELISA Kit for Sandwich ELISA - ABIN435933
Lai, Yu, Qian, Wei, Lv, Xu: Chronic alcoholism-mediated impairment in the medulla oblongata: a mechanism of alcohol-related mortality in traumatic brain injury? in Cell biochemistry and biophysics 2013
Rat (Rattus) DLG4 ELISA Kit for Sandwich ELISA - ABIN858839
Alam: Selective Brain-Targeted Antagonism of p38 MAPK? Reduces Hippocampal IL-1? Levels and Improves Morris Water Maze Performance in Aged Rats. in Journal of Alzheimer's disease : JAD 2015
Exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh (显示 DVL2 ELISA试剂盒) protein for Wg ligand reception in Drosophila. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh (显示 DVL2 ELISA试剂盒) protein from lysosomal degradation.
Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (显示 ACD ELISA试剂盒)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (显示 ACD ELISA试剂盒), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.
The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.
Loss of scrib (显示 SCRIB ELISA试剂盒), dlg and lgl had no effect on gonad formation, but Dlg and Scrib (显示 SCRIB ELISA试剂盒) in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.
Gliotactin and Discs large are co-regulated to maintain epithelial integrity.
Hts (显示 APCDD1 ELISA试剂盒) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.
Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.
DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization
Study provide evidence that scrib (显示 SCRIB ELISA试剂盒) and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib (显示 SCRIB ELISA试剂盒) and dlg act in a common pathway to regulate PFC (显示 CFP ELISA试剂盒) fate induction.
integrins act through CaMKII (显示 CAMK2 ELISA试剂盒) activation to control the localization of dlg in the development of NMJ synaptic morphology
This study demonstrated that in Chronic social defeat stress leads to changes PSD-95 in hippocampus of young mice.
The authors present evidence that synGAP (显示 SYNGAP1 ELISA试剂盒)-alpha1 regulates the composition of the postsynaptic density by restricting binding to the PDZ (显示 INADL ELISA试剂盒) domains of PSD-95.
In Fmr1 (显示 FMR1 ELISA试剂盒) KO neurons, Mdm2 (显示 MDM2 ELISA试剂盒) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (显示 MEF2C ELISA试剂盒) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (显示 TSFM ELISA试剂盒) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (显示 FMR1 ELISA试剂盒) KO. Expression of a dephosphomimetic of Mdm2 (显示 MDM2 ELISA试剂盒) rescues PSD-95 ubiquitination, degradation and synapse elimination in Fmr1 (显示 FMR1 ELISA试剂盒) KO neurons.
tested the effect of five targeted mouse mutations on the assembly of known PSD95 interactors, Kir2.3 (显示 KCNJ4 ELISA试剂盒), Arc (显示 NOL3 ELISA试剂盒), IQsec2/BRAG1 (显示 IQSEC2 ELISA试剂盒) and Adam22 (显示 ADAM22 ELISA试剂盒)
Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI.
PSD95 and SYP (显示 PTPN11 ELISA试剂盒) may originate from the different sites, but they are closely related to the formation and maturation of synapse.
Expression levels of brain derived neurotrophic factor (显示 BDNF ELISA试剂盒), postsynaptic density 95 (显示 DLGAP2 ELISA试剂盒), and p-cyclic-AMP response element binding protein (显示 CREB ELISA试剂盒) levels were significantly elevated in the testosterone (T) group, but flutamide reduced the T-induced effects in these biomarkers to control levels.
The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN (显示 SYP ELISA试剂盒) and PSD95 expression, which is critical for structural synaptic plasticity.
critical roles of PSD-95 in regulating synaptic kainate receptors.
Phenylketonuric mice given a specific nutrient combination showed a significant reduction in PSD-95 expression in the hippocampus, specifically in the granular cell layer of the dentate gyrus, with a similar trend seen in the cornus ammonis 1 (CA1 (显示 CA1 ELISA试剂盒)) and cornus ammonis 3 (CA3 (显示 CA3 ELISA试剂盒)) pyramidal cell layer.
Phosphorylation at Y397 induced a significant increase in affinity for stargazing. The strategy presented here to generate site-specifically phosphorylated PDZ (显示 INADL ELISA试剂盒) domains provides a detailed understanding of the role of phosphorylation in the regulation of PSD95 interactions.
This study demonstrated that a significant decrease in the protein level of PSD-95 in major depression disorder.
These results indicate that PKC promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 (显示 MAPK8 ELISA试剂盒) and calcium/calmodulin-dependent kinase (显示 CAMK2 ELISA试剂盒) II and also by inducing expression of PSD-95 and synaptophysin (显示 SYP ELISA试剂盒).
The differences in cortical NMDAR (显示 GRIN1 ELISA试剂盒) expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.
Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders.
Data demonstrate a role for SNAP-25 (显示 SNAP25 ELISA试剂盒) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.
Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ (显示 INADL ELISA试剂盒) domains.
In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles
An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.
Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin (显示 SYP ELISA试剂盒) and before neuronal loss in patients with Alzheimer's disease.
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
, disc large
, discs large
, disk large
, lethal(1)benign wing imaginal disc neoplasm
, lethal(1)discs large
, lethal(2)discs large
, discs, large homolog 4
, postsynaptic density protein 95
, disks large homolog 4
, PSD-95 alpha 2b
, PSD-95 beta
, discs large homolog 4
, synapse-associated protein 90
, synapse-associated protein SAP90
, Tax interaction protein 15
, post-synaptic density protein 95