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A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1/SKAP-HOM (显示 SKAP2 蛋白) and SLP-76 (显示 LCP2 蛋白)/Vav (显示 VAV1 蛋白)/PLCgamma2 (显示 PLCG2 蛋白) signaling hubs may be critical for Yersinia survival.
autophagy contributes to the anti-apoptotic function of the PML (显示 PML 蛋白)-RARalpha (显示 RARA 蛋白) protein through inhibiting the Akt (显示 AKT1 蛋白)/mTOR (显示 FRAP1 蛋白) pathway
Transgenic mice expressing PML-RAR alpha (显示 RARA 蛋白) develop acute promyelocytic leukemia (显示 PML 蛋白) with long latency, low penetrance, and acquired cytogenetic abnormalities.
Our results show that the pretreatment PML (显示 PML 蛋白)-RARA (显示 RARA 蛋白) molecular burden could therefore be used to improve risk stratification in order to develop more individualized treatment regimens for high-risk APL (显示 FASL 蛋白) cases.
The 3-plex RT-qPCR assay is a specific, sensitive, stable, and cost-effective method that can be used for the rapid diagnosis and treatment monitoring of acute promyelocytic leukemia (显示 PML 蛋白) with PML (显示 PML 蛋白)-RARa (显示 RARA 蛋白)
The MIR125B1-mediated blockade of PML (显示 PML 蛋白)-RARA (显示 RARA 蛋白) proteolysis was regulated via an autophagy-lysosomal pathway, contributing to the inhibition of acute promyelocytic leukemia (显示 PML 蛋白) differentiation.
PRAM-1 is required for optimal integrin-dependent neutrophil function.
Caspase 3 (显示 CASP3 蛋白)-cleaved SH3 domain of HIP-55 (显示 DBNL 蛋白) is likely involved in PRAM-1-mediated JNK (显示 MAPK8 蛋白) activation upon arsenic trioxide-induced differentiation of NB4 cells.
The use of reverse-transcription polymerase chain reaction for the detection of the PML (显示 PML 蛋白)-RARA (显示 RARA 蛋白) and RARA (显示 RARA 蛋白)-PML (显示 PML 蛋白) fusion genes that allow for monitoring of acute myelocytic leukemia.
PML (显示 PML 蛋白)-RARalpha (显示 RARA 蛋白) fusion transcripts have been shown to be useful markers for establishing the diagnosis and for monitoring the response to treatment of acute promyelocytic leukemia (显示 PML 蛋白).
Interaction of PRAM-1 and hSH3 domains of adhesion and degranulation promoting adapter protein (显示 TOLLIP 蛋白) (ADAP (显示 FYB 蛋白)) with phosphatidylcholine (显示 SGMS2 蛋白)-containing liposomes is observed upon incorporation of phosphatidylserine or phosphoinositides into the membrane bilayer.
hidden abnormalities and novel disease-related genomic changes occur in t(15;17)translocation in acute promyelocytic leukemia (显示 PML 蛋白) formation of PML (显示 PML 蛋白)-RARA (显示 RARA 蛋白) gene
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).
PML-RARA regulated adaptor molecule 1
, PML-RARA-regulated adapter molecule 1-like
, PML-RARA-regulated adapter molecule 1
, PML-RARA target gene encoding an Adaptor Molecule-1
, PML-RAR alpha-regulated adaptor molecule 1