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findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30 (显示 NCR3 ELISA试剂盒)) and IFN-gamma (显示 IFNG ELISA试剂盒) inducibility upon NCR and cytokine receptor (显示 EBI3 ELISA试剂盒) engagement
NKp46 cleavage by Cathepsin G (显示 CTSG ELISA试剂盒) severely impairs NKp46-mediated responses of Natural killer cells.
The NKp46 and NKp46-ligand interaction contributes to NK cell activation.
this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells
Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals.
Taken together, these results demonstrate that endogenous levels of IFN-alpha (显示 IFNA ELISA试剂盒) secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4 (显示 CD4 ELISA试剂盒)+ primary T cells via the engagement of NKp46 and NKG2D (显示 KLRK1 ELISA试剂盒).
NKp46 was thus involved in the production of serine proteases and interleukin-22 (显示 IL22 ELISA试剂盒) in human mast cells.
Age and CMV serostatus influence the expression of NKp30 (显示 NCR3 ELISA试剂盒), NKp46 and DNAM-1 (显示 CD226 ELISA试剂盒) activating receptors on resting and IL-2 (显示 IL2 ELISA试剂盒) activated natural killer cells.
Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios (显示 ZNFN1A2 ELISA试剂盒) expression
Data show that regulatory dendritic cells (regDC) restrain IFN-gamma (显示 IFNG ELISA试剂盒) secretion by NK cells through secretion of interleukin-10 (IL-10 (显示 IL10 ELISA试剂盒)), engagement of MHC class I-specific inhibitory receptors, and the activating receptor NKp46.
this study demonstrates the role of NCR1 in antibody response to mouse cytomegalovirus infection
Our findings uncover a detrimental role of T-bet-dependent NKp46(+) ILCs in the development of CNS autoimmune disease.
The results identify an unexpected phenotypic instability within NKp46(+) ILC3 that suggests a major role for environmental signals in tuning ILC3 functional plasticity.
The authors delineated the fungal ligands to be the Candida glabrata adhesins Epa1, Epa6 (显示 Epha6 ELISA试剂盒), and Epa7 and demonstrated that clearance of systemic Candida glabrata infections in vivo depends on their recognition by mouse NCR1.
it is demonstrated that NCR1 dampens allergic eosinophilic airway inflammation.
this study using Ncr1-deficient mice, shows that NCR1 plays a critical role in controlling human metapneumovirus infection
Rag knockout mice that possess fully functional NKp46(+) cells
NK cell receptor (显示 KLRD1 ELISA试剂盒) NKp46 regulates graft-versus-host disease.
Ifnar1 (显示 IFNAR1 ELISA试剂盒)(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack.
has similarity to immunoglobulins\; expressed in NK cells
NK cell-activating receptor
, lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)
, natural killer cell p46-related protein
, MAR1 (mouse activating receptor 1)
, activating receptor 1
, lymphocyte antigen 94
, NK receptor KILR-1
, lymphocyte antigen 94 homolog (activating NK-receptor
, rat-activating receptor 1