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抗Mouse (Murine) DCC 抗体:
抗Human DCC 抗体:
抗Rat (Rattus) DCC 抗体:
Human Monoclonal DCC Primary Antibody for FACS, WB - ABIN967442
Fearon, Cho, Nigro, Kern, Simons, Ruppert, Hamilton, Preisinger, Thomas, Kinzler: Identification of a chromosome 18q gene that is altered in colorectal cancers. in Science (New York, N.Y.) 1990
Show all 5 Pubmed References
Human Monoclonal DCC Primary Antibody for IHC (f), WB - ABIN967443
Fearon, Hamilton, Vogelstein: Clonal analysis of human colorectal tumors. in Science (New York, N.Y.) 1987
Show all 5 Pubmed References
Authors demonstrate that tripartite motif protein 9 (TRIM9 (显示 TRIM9 抗体))-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK (显示 PTK2 抗体).
Together, these results demonstrate that the production of DCC splice variants controlled by NOVA (显示 HNRNPK 抗体) has a crucial function during many stages of commissural neuron development.
Results show that deleted in colorectal cancer receptors contribute to the dynamic refinement of dopamine D1 and D2 receptor (显示 DRD2 抗体) expression in striatal regions across adolescence. The age-dependent expression of dopamine receptor in C57BL6 mice shows marked differences from previous characterizations in rats.
abrogated ABCC6 (显示 ABCC6 抗体) function does cause alterations in the metabolic profile of the liver in accordance with PXE (显示 ABCC6 抗体) being a metabolic disease originating from liver disturbance
Results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord.
Results suggest that Dcc plays an important role in the developmental formation of peripheral and central auditory circuits, and its mutation may contribute to sensorineural hearing loss.
dcc haploinsufficient mice acquire intracranial self-stimulation behavior and that the parameters of the stimulation are comparable to those observed in wild-type littermates; reduced expression of dcc may dampen the abuse potential of cocaine
Identified the Dcc gene as a novel downstream target of spontaneous calcium activity involved in axon growth.
bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 (显示 ABCC6 抗体) gene.
suggest that DCC signaling functions through NCK1 (显示 NCK1 抗体) and NCK2 (显示 NCK2 抗体) and that both proteins are necessary for the establishment of normal spinal circuits necessary for gait
Schwann cell and dcc-mediated guidance are critical early during regeneration to direct growth cones across the transection gap and onto their original axonal trajectory.
in dcc mutants, turns on the inappropriate side of the body are caused by aberrant ipsilateral axonal projections
Dcc-Netrin1 and roundabout2 (Robo2)-Slit coordinate axonal projection choices of neurons in the developing forebrain.
Dcc regulates polarized axon initiation and asymmetric outgrowth of forebrain neurons
dcc may play roles not only in axon guidance, but in morphogenesis and functioning of these organs as well
First evidence that Netrin/DCC axon guidance molecules act in dendrites in a vertebrate system.
ESCRT-II (显示 VPS28 抗体)-mediated endocytic pathway regulates both DCC and local protein synthesis.
Somatic DCC mutations are associated with metastatic NUT midline carcinoma.
Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin (显示 NEO1 抗体).
Identified DCC mutations in four families.
DCC polymorphism maybe responsible for successful treatment of patients with hydrochlorothiazide . diagnosed with hypertension.
Deleted in colorectal cancer (DCC) confers susceptibility to depression-like behaviors in humans and mice and Is regulated by miR (显示 MLXIP 抗体)-218. By regulating DCC, miR (显示 MLXIP 抗体)-218 may be a switch of susceptibility versus resilience to stress-related disorders.
DCC/18q and ERBB2 (显示 ERBB2 抗体)/17q gene copy number variations are associated with disease-free survival in microsatellite stable colon cancer
Allelic and genotypic frequencies of the DCC polymorphism rs2229080 were nominally associated with schizophrenia.
Results of APC and DCC LOH, KRAS and microsatellite instability indicate our colorectal cancer cases were typical of sporadic cancers following the 'chromosomal instability' pathway.
The study identified DCC as a differentially expressed gene and clustered meningiomas into DCC low expression (3 grade I and 3 grade II tumors), DCC medium expression (2 grade I and 1 grade II tumors), and DCC high expression (5 grade I tumors) groups.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
ATP-binding cassette sub-family C member 6
, ATP-binding cassette, sub-family C, member 6
, multidrug resistance-associated protein 6
, multidrug resistance-associated protein-6
, deleted in colorectal carcinoma
, netrin receptor DCC
, deleted in colorectal cancer
, deleted in colorectal cancer tumor suppressor
, netrin receptor DCC-like
, colorectal cancer suppressor
, colorectal tumor suppressor
, deleted in colorectal cancer protein
, immunoglobulin superfamily DCC subclass member 1
, immunoglobulin superfamily, DCC subclass, member 1
, tumor suppressor protein DCC