anti-GRB10 (GRB10) 抗体产品概述

Full name:
anti-Growth Factor Receptor-Bound Protein 10 抗体 (GRB10)
在www.antibodies-online.cn可供89 Growth Factor Receptor-Bound Protein 10 (GRB10) 抗体的22不同的供货商。 再加上,我们可以发GRB10 试剂盒 (36)GRB10 蛋白 (8)和数多这个蛋白质的别的产品。 总共141 GRB10产品已列进来了。
别名:
5730571D09Rik, AI325020, Grb-10, GRB-IR, GRB10, IRBP, LOC100224775, MEG1, mKIAA0207, RGD1566234, RSS, zgc:91987
列出全部抗体 基因 基因ID UniProt
GRB10 14783 Q60760
GRB10 498416  
GRB10 2887 Q13322

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引用最多的anti-GRB10 抗体

  1. Human Polyclonal GRB10 Primary Antibody for WB - ABIN1881389 : ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for 1881389

  2. Human Polyclonal GRB10 Primary Antibody for IF, ELISA - ABIN1531649 : Angrist, Bolk, Bentley, Nallasamy, Halushka, Chakravarti: Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. in Oncogene 1999 (PubMed)

更多抗GRB10的相互作用对抗体

Mouse (Murine) Growth Factor Receptor-Bound Protein 10 (GRB10) interaction partners

  1. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development.

  2. This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues.

  3. Negative regulation of Grb10 Interacting GIGYF2 (显示 GIGYF2 抗体) protein on IGF-1 (显示 IGF1 抗体) receptor signaling pathway caused diabetic mice cognitive impairment.

  4. Grb10 is involved in BCR-ABL (显示 ABL1 抗体)-positive leukemia in mice.

  5. Grb10 is a key genetic component of developmental programming.

  6. Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin (显示 INS 抗体) signaling and an increase in GLUT4 (显示 SLC2A4 抗体) translocation to the plasma membrane.

  7. Grb10 expression in mouse embryo is regulated by Lmx1a (显示 LMX1A 抗体) transcription factor.

  8. Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells.

  9. Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis.

  10. Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions

Human Growth Factor Receptor-Bound Protein 10 (GRB10) interaction partners

  1. Data suggest that GRB10 and GRB14 (显示 GRB14 抗体) are both Ca2 (显示 CA2 抗体)+-dependent CaM (显示 CALM1 抗体)-binding proteins; more than one CaM (显示 CALM1 抗体)-binding site and/or accessory CaM (显示 CALM1 抗体)-binding sites appear to exist in GRB10 and GRB14 (显示 GRB14 抗体), as compared to a single one present in GRB7 (显示 GRB7 抗体). (GRB10 = growth factor receptor-bound protein 10; GRB14 (显示 GRB14 抗体) = growth factor receptor-bound protein 14 (显示 GRB14 抗体); CaM (显示 CALM1 抗体) = calmodulin (显示 CALM1 抗体); GRB7 (显示 GRB7 抗体) = growth factor receptor-bound protein 7 (显示 GRB7 抗体))

  2. GRB10 may regulate degradation of the IL-4 (显示 IL4 抗体) receptor-signaling complex through interactions with NEDD4.2 (显示 NEDD4L 抗体).

  3. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (显示 ADCY5 抗体), ADRA2A (显示 ADRA2A 抗体), CDKAL1 (显示 CDKAL1 抗体), CDKN2A (显示 CDKN2A 抗体)/B, GRB10, and TCF7L2 (显示 TCF7L2 抗体)

  4. This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene.

  5. Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight.

  6. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.

  7. Grb10 binds to both normal and oncogenic FLT3 (显示 FLT3 抗体) and induces PI3K (显示 PIK3CA 抗体)-Akt (显示 AKT1 抗体) and STAT5 (显示 STAT5A 抗体) signaling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells.

  8. Studies indicate that insulin receptor (IR (显示 INSR 抗体)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1 (显示 SH2B1 抗体)/B2 adaptors.

  9. H19 (显示 NCKAP1 抗体) and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients.

  10. discovery of Grb10 as an mTORC1 substrate

GRB10 抗原简介

Antigen Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with GRB10

  • growth factor receptor-bound protein 10 (GRB10) 抗体
  • growth factor receptor-bound protein 10a (grb10a) 抗体
  • growth factor receptor-bound protein 10 (grb10) 抗体
  • growth factor receptor-bound protein 10 (LOC100224775) 抗体
  • growth factor receptor bound protein 10 (Grb10) 抗体
  • growth factor receptor-bound protein 10 (Grb10) 抗体
  • growth factor receptor-bound protein 10-like (LOC100355737) 抗体
  • 5730571D09Rik 抗体
  • AI325020 抗体
  • Grb-10 抗体
  • GRB-IR 抗体
  • GRB10 抗体
  • IRBP 抗体
  • LOC100224775 抗体
  • MEG1 抗体
  • mKIAA0207 抗体
  • RGD1566234 抗体
  • RSS 抗体
  • zgc:91987 抗体

Protein level used designations for GRB10

growth factor receptor-bound protein 10 , zgc:91987growth factor receptor-bound protein 10 , growth factor receptor-bound protein 10-like , GRB10 adapter protein , maternally expressed gene 1 protein , GRB10 adaptor protein , insulin receptor-binding protein Grb-IR , maternally expressed gene 1 , adapter protein , binds to insulin receptor and IGF1R

GENE ID SPECIES
100052610 Equus caballus
446167 Danio rerio
463410 Pan troglodytes
694786 Macaca mulatta
100151701 Xenopus (Silurana) tropicalis
100224775 Taeniopygia guttata
100381089 Xenopus laevis
100402854 Callithrix jacchus
100434903 Pongo abelii
100476882 Ailuropoda melanoleuca
100542734 Meleagris gallopavo
100564990 Anolis carolinensis
100599409 Nomascus leucogenys
14783 Mus musculus
498416 Rattus norvegicus
2887 Homo sapiens
607755 Canis lupus familiaris
100188977 Sus scrofa
407210 Bos taurus
100733471 Cavia porcellus
420948 Gallus gallus
101111275 Ovis aries
100355737 Oryctolagus cuniculus
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