anti-LATS1 (LATS1) 抗体产品概述

Full name:
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) 抗体 (LATS1)
在www.antibodies-online.cn可供78 LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) 抗体的14不同的供货商。 再加上,我们可以发和数多这个蛋白质的别的产品。 总共89 LATS1产品已列进来了。
别名:
AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, wts, wu:fc19a11, zgc:123219
列出全部抗体 基因 基因ID UniProt
LATS1 16798 Q8BYR2
LATS1 9113 O95835
LATS1 308265  

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引用最多的anti-LATS1 抗体

  1. Human Polyclonal LATS1 Primary Antibody for IHC (p), WB - ABIN391033 : Iida, Hirota, Morisaki, Marumoto, Hara, Kuninaka, Honda, Kosai, Kawasuji, Pallas, Saya: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. in Oncogene 2004 (PubMed)
    Show all 6 references for 391033

  2. Cow (Bovine) Polyclonal LATS1 Primary Antibody for WB - ABIN2787626 : Zhang, Smolen, Haber: Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. in Cancer research 2008 (PubMed)

  3. Human Polyclonal LATS1 Primary Antibody for IP, WB - ABIN4891893 : Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015 (PubMed)

  4. Human Polyclonal LATS1 Primary Antibody for EIA, IHC (p) - ABIN359091 : Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. in Blood 2008 (PubMed)

  5. Human Polyclonal LATS1 Primary Antibody for IF (p), IHC (p) - ABIN872292 : Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration. in American journal of physiology. Gastrointestinal and liver physiology 2014 (PubMed)

更多抗LATS1的相互作用对抗体

Zebrafish LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Thus AMOT (显示 AMOT 抗体) is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 (显示 LATS2 抗体) is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.

Mouse (Murine) LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Study demonstrates that, in 3 different murine syngeneic tumor models (B16, SCC7, and 4T1), loss of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in tumor cells inhibits tumor growth; data indicate a new paradigm for how tumor immunogenicity is regulated through the Hippo signaling pathway in tumor cells.

  2. Results showed that the Hippo pathway is active in ovarian follicles and that LATS1 is required to maintain the pool of germ cells and primordial follicles.

  3. The control of LATS activation by angiotensin II and subsequent YAP (显示 YAP1 抗体) localization is important for podocyte homeostasis and survival.

  4. Willin (显示 FRMD6 抗体) is predominantly expressed in fibroblasts and that Willin (显示 FRMD6 抗体) expression activates the Hippo signaling cascade

  5. LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization.

  6. KIBRA (显示 WWC1 抗体) associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  7. Lats1 enhances the activity of FOXl2 (显示 FOXL2 抗体) as a repressor of the StAr promoter. st

  8. Overexpression of YAP2 (显示 YAP1 抗体) in cells promoted apoptosis, whereas the Mst2 (显示 STK3 抗体)/Lats1-induced phosphorylation of YAP (显示 YAP1 抗体) partially rescued the cells from apoptotic death.

  9. Genome-wide location arrays in cell lines of various cell types revealed that Lats1 was a transcriptional target of CUX1 (显示 CUX1 抗体).

Human LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. TNFAIP8 (显示 TNFAIP8 抗体) regulates Hippo (MST1 (显示 MST1 抗体)/2) signaling through its interaction with LATS1.

  2. Lats1 SUMOylation at K751 suppresses its kinase activity and subsequently attenuates its tumor-suppressor functions in HepG2 cells.

  3. High LATS1 expression is associated with Colorectal Tumorigenesis and Metastasis.

  4. A group of miRNAs have been demonstrated to directly target components of the Hippo signaling pathway, such as YAP (显示 YAP1 抗体), TAZ (显示 TAZ 抗体) and LATS1/2 in oncogenesis. (Review)

  5. findings reveal a non-canonical (that is, YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体)-independent) effect of LATS in the regulation of human breast cell fate

  6. AGO2 (显示 EIF2C2 抗体) immunoprecipitation revealed LATS1 as a novel proapoptotic target of miR (显示 MLXIP 抗体)-21 in T cells.

  7. LATS1 was downregulated in cervical cancer and may suppress cell growth and invasion through regulating the expression of cyclin E (显示 CCNE1 抗体), p27 (显示 PAK2 抗体), MMP9 (显示 MMP9 抗体) and YAP (显示 YAP1 抗体).

  8. PARD3 (显示 PARD3 抗体) promotes interaction between PP1A (显示 PPP1CA 抗体) and LATS1 to induce LATS1 dephosphorylation and inactivation,leading to dephosphorylation and activation of TAZ (显示 TAZ 抗体)

  9. Loss of LATS1 expression is associated with breast neoplasms.

  10. Phosphorylation of CHO1 (显示 KIF23 抗体) at S716 by Lats1 regulate its centrosomal localization, and that phosphorylated CHO1 (显示 KIF23 抗体) interacts with and activates LIMK1 (显示 LIMK1 抗体) during early mitosis.

LATS1 抗原简介

Antigen Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Alternative names and synonyms associated with LATS1

  • LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) 抗体
  • LATS, large tumor suppressor, homolog 1 (Drosophila) (lats1) 抗体
  • LATS, large tumor suppressor, homolog 1 (TEgg117h14.1) 抗体
  • large tumor suppressor (Lats1) 抗体
  • large tumor suppressor kinase 1 (LATS1) 抗体
  • large tumor suppressor kinase 1 (Lats1) 抗体
  • AW208599 抗体
  • Lats 抗体
  • lats1 抗体
  • RGD1564085 抗体
  • si:dkey-181i3.5 抗体
  • WARTS 抗体
  • wts 抗体
  • wu:fc19a11 抗体
  • zgc:123219 抗体

Protein level used designations for LATS1

large tumor suppressor , serine/threonine-protein kinase LATS1 , LATS homolog 1 , LATS, large tumor suppressor, homolog 1 , LATS, large tumor suppressor, homolog 1 (Drosophila) , serine/threonine-protein kinase LATS1-like , WARTS protein kinase , large tumor suppressor homolog 1 , large tumor supressor, homolog 1 , LATS (large tumor suppressor, Drosophila) homolog 1 , h-warts , large tumor suppressor 1

GENE ID SPECIES
100060397 Equus caballus
553164 Danio rerio
748397 Pan troglodytes
100145677 Xenopus (Silurana) tropicalis
100410314 Callithrix jacchus
100455398 Pongo abelii
100467078 Ailuropoda melanoleuca
100539393 Meleagris gallopavo
100599863 Nomascus leucogenys
16798 Mus musculus
9113 Homo sapiens
308265 Rattus norvegicus
421627 Gallus gallus
100152165 Sus scrofa
535935 Bos taurus
476241 Canis lupus familiaris
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