MCTS1 Protein (AA 1-181, full length) (His-SUMO Tag)
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- 抗原 See all MCTS1 蛋白
- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-181
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This MCTS1 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV KIVRCHEHIE ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG AKLYPAAVDT IVAIMAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY K
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product MCTS1 蛋白
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Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) protein (His tag)
MCTS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) protein (GST tag)MCTS1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) protein (Strep Tag)Crystallography grade MCTS1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181), (full length) protein (His-SUMO Tag)MCTS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Malignant T Cell Amplified Sequence 1 (MCTS1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)MCTS1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
- 别名
- MCTS1 (MCTS1 产品)
- 别名
- MCT-1 Protein, MCT1 Protein, MCT1a Protein, cb517 Protein, zgc:55682 Protein, 1500019M23Rik Protein, zgc:56242 Protein, mcts1 Protein, MGC89874 Protein, MCTS1 Protein, MCT-1A Protein, mct-1 Protein, mct1 Protein, MCT-1B Protein, mcts1-a Protein, mcts1-b Protein, MCTS1, re-initiation and release factor Protein, solute carrier family 16 (monocarboxylate transporter), member 1b Protein, malignant T cell amplified sequence 1 Protein, malignant T-cell amplified sequence 1 Protein, solute carrier family 16 member 1 Protein, malignant T-cell amplified sequence 1 S homeolog Protein, monocarboxylate transporter 1 Protein, malignant T-cell amplified sequence 1 L homeolog Protein, MCTS1 Protein, slc16a1b Protein, Mcts1 Protein, mcts1 Protein, SLC16A1 Protein, mcts1.S Protein, MCT1 Protein, mcts1.L Protein
- 背景
- Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels rains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits
- 分子量
- 36.54 kDa
- UniProt
- Q9ULC4
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