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GM-CSF (AA 18-144) (Active) 蛋白

ABIN2181169 产品详细信息, 供应商: Log in to see
蛋白名称
  • GM-CSF
  • granulocyte-macrophage colony-stimulating-factor
  • granulocyte-macrophage colony-stimulating factor
  • GM-CSF
产品特性
AA 18-144
11
8
宿主

45
21
11
2
1
1
资源
HEK-293 Cells
64
4
4
4
2
1
1
1
蛋白类型
Recombinant
生物活性
Active
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品牌 ActiveMax®
产品特性 This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 16-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
纯度 >95 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 0.1 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50<25 pg/mL, corresponding to a specific activity of >4E+7 Unit/mg.

SDS-PAGE: due to glycosylation.
背景 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.
分子量 14.5 kDa
NCBI登录号 NP_000749
UniProt P04141
研究领域 Immunology, Innate Immunity, Cytokines
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for GM-CSF (AA 18-144) (Active) 蛋白 (ABIN2181169) Human GM-CSF on SDS-PAGE under reducing (R) condition. The gel was stained overnight ...
背景 Ait-ghezala, Abdullah, Volmar, Paris, Luis, Quadros, Mouzon, Mullan, Keegan, Parrish, Crawford, Mathura, Mullan: "Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease." in: Cytokine, Vol. 44, Issue 2, pp. 283-7, 2008 (PubMed).