Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF) (AA 2-115), (full length) protein (His tag)

ABIN1047347 产品详细信息, 供应商: Log in to see
蛋白名称
  • mif
  • Mif
  • gif
  • glif
  • mmif
  • LOC100136498
  • LOC100284350
  • LOC100284546
  • GIF
  • Glif
  • GLIF
  • MMIF
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor)
  • macrophage migration inhibitory factor
  • Macrophage migration inhibitory factor
  • mif
  • MIF
  • Mif
  • PHATRDRAFT_49660
  • LOC100136498
  • LOC100284350
  • LOC100284546
  • LOC100338701
产品特性
AA 2-115, full length
17
10
4
2
2
1
宿主

45
17
3
1
1
1
资源
大肠杆菌(E. Coli)
52
4
2
1
1
1
1
蛋白类型
Recombinant
标记
This MIF protein is labelled with His tag.
应用范围
ELISA
选项
Supplier
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Supplier Product No.
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序列 PMFIVNTNVP RASVPDGFLS ELTQQLAQAT GKPPQYIAVH VVPDQLMAFG GSSEPCALCS LHSIGKIGGA QNRSYSKLLC GLLAERLRIS PDRVYINYYD MNAANVGWNN STFA
产品特性 Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
纯度 90 %
背景 Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Ref.23 Ref.25
分子量 16.4 kD
UniProt P14174
途径 Regulation of Systemic Arterial Blood Pressure by Hormones, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
说明

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

限制 仅限研究用
状态 Lyophilized
浓度 0.2-2 mg/mL
缓冲液 Tris-based buffer, 50 % glycerol
注意事项 Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
储存条件 -20 °C
储存方法 Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
厂商提供的图像
SDS-PAGE (SDS) image for Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF) (AA 2-115), (full length) protein (His tag) (ABIN1047347) Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF) (AA 2-...
背景 Mikayama, Nakano, Gomi, Nakagawa, Liu, Sato, Iwamatsu, Ishii, Weiser, Ishizaka: "Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 21, pp. 10056-60, 1993 (PubMed).

Weiser, Temple, Witek-Giannotti, Remold, Clark, David: "Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 19, pp. 7522-6, 1989 (PubMed).

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