BIK 蛋白 (BIK)产品概述

Full name:
BCL2-Interacting Killer (Apoptosis-Inducing) 蛋白 (BIK)
在www.antibodies-online.cn可供5 BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) 蛋白的3不同的供货商。 再加上,我们可以发BIK 抗体 (120)BIK 试剂盒 (5)和数多这个蛋白质的别的产品。 总共145 BIK产品已列进来了。
别名:
BIK, Biklk, BIP1, Blk, BP4, NBK, si:dkey-31f5.6
列出全部蛋白 基因 基因ID UniProt
BIK 12124  
BIK 638 Q13323
大鼠 BIK BIK 114496  

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Mouse (Murine) BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. These studies suggest a link between Bik-mediated caspase (显示 CASP3 蛋白) activation and cleavage of viral proteins.

  2. OPN (显示 SPP1 蛋白) induces oxidative stress via the involvement of mitochondria and NOX-4 (显示 NOX4 蛋白). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK.

  3. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (显示 SQSTM1 蛋白) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  4. Src (显示 SRC 蛋白) tyrosine kinase (显示 TYRO3 蛋白) inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

  5. The Bik protein, even in combination with Noxa (显示 PMAIP1 蛋白), is not a potent suppressor of c-Myc (显示 MYC 蛋白)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (显示 MYC 蛋白)-driven tumours.

  6. BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.

  7. Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.

  8. any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (显示 BBC3 蛋白) proteins

  9. Data show that Bik and Bim (显示 BCL2L11 蛋白) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.

  10. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR-VISA (显示 MAVS 蛋白), exhibited antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic mouse models of pancreatic tumors with virtually no toxicity

Human BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. These studies suggest a link between Bik-mediated caspase (显示 CASP3 蛋白) activation and cleavage of viral proteins.

  2. our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (显示 CCNA1 蛋白) and favors a more aggressive phenotype, due to the molecular change of different pathways

  3. HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression

  4. BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.

  5. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (显示 SQSTM1 蛋白) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  6. Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.

  7. Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (显示 MAPK1 蛋白) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (显示 MAPK1 蛋白) signaling.

  8. BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients

  9. Src (显示 SRC 蛋白) tyrosine kinase (显示 TXK 蛋白) inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.

  10. A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 (显示 TP73 蛋白) lacking its transactivation domain that activates BIK through a proximal element in its promoter.

蛋白简介BIK

蛋白简介

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.

Alternative names and synonyms associated with BIK

  • BCL2-interacting killer (apoptosis-inducing) (BIK)
  • BCL2-interacting killer (BIK)
  • BCL2-interacting killer (Bik)
  • BCL2-interacting killer (apoptosis-inducing) (Bik)
  • BCL2-interacting killer (apoptosis-inducing) (bik)
  • BIK 蛋白
  • Biklk 蛋白
  • BIP1 蛋白
  • Blk 蛋白
  • BP4 蛋白
  • NBK 蛋白
  • si:dkey-31f5.6 蛋白

Protein level used designations for BIK

BCL2-interacting killer (apoptosis-inducing) , BCL2-interacting killer , apoptosis inducer NBK , bcl-2-interacting killer , bik-like killer protein , apoptosis-inducing NBK

GENE ID SPECIES
470232 Pan troglodytes
711479 Macaca mulatta
790946 Felis catus
12124 Mus musculus
638 Homo sapiens
114496 Rattus norvegicus
564030 Danio rerio
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