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miR (显示 MYLIP ELISA试剂盒)-375 directly targeted PDK1 (显示 PDK1 ELISA试剂盒) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (显示 AKT1 ELISA试剂盒).
High (显示 PDK1 ELISA试剂盒)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (显示 PDK1 ELISA试剂盒)ynovial (显示 PDK1 ELISA试剂盒)MH7A c (显示 RPS6KA3 ELISA试剂盒)ells. Inhib (显示 RPS6KA3 ELISA试剂盒)ition of RSK2 reduced the PDK (显示 ASF1A ELISA试剂盒)1-induced cell invasion and cytokines secretion (显示 PDK1 ELISA试剂盒) in M (显示 RPS6KA3 ELISA试剂盒)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha (显示 PIK3CA ELISA试剂盒) inhibition, PDK1 (显示 PDK1 ELISA试剂盒) blockade restores sensitivity to these therapies. SGK1 (显示 SGK1 ELISA试剂盒), which is activated by PDK1 (显示 PDK1 ELISA试剂盒), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (显示 TSC2 ELISA试剂盒).
Results suggest that Ser (显示 SIGLEC1 ELISA试剂盒)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (显示 PDK1 ELISA试剂盒)-PKCtheta (显示 PRKCQ ELISA试剂盒);-mediated T cell activation.
Elevated expression of PDK1 (显示 PDK1 ELISA试剂盒) was an independent negative prognostic factor of gastric carcinoma.
miR (显示 MLXIP ELISA试剂盒)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (显示 PDK1 ELISA试剂盒).
miR (显示 MLXIP ELISA试剂盒)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (显示 PDK1 ELISA试剂盒) expression.
Decreased PDK1 (显示 PDK1 ELISA试剂盒) level is closely associated with reduced Akt (显示 AKT1 ELISA试剂盒)/cyclin D1 (显示 CCND1 ELISA试剂盒) activity.
MiR (显示 MLXIP ELISA试剂盒)-138 regulation of PI3K (显示 PIK3CA ELISA试剂盒) signaling in ASMCs by altering the expression of PDK1 (显示 PDK1 ELISA试剂盒).
Dephosphorylation of PDK-1 (显示 PDK1 ELISA试剂盒) and the resulting changes to Akt (显示 AKT1 ELISA试剂盒) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (显示 NOTCH1 ELISA试剂盒)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (显示 RPS6KA3 ELISA试剂盒) and p-RSK2 (显示 RPS6KA3 ELISA试剂盒) were all up-regulated in CIA (显示 NCOA5 ELISA试剂盒) compared with normal. This indicated that PDK1/RSK2 (显示 RPS6KA3 ELISA试剂盒) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (显示 CA2 ELISA试剂盒)+)-dependent platelet activation on stimulation of collagen receptor (显示 ITGA2 ELISA试剂盒) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (显示 INS ELISA试剂盒)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (显示 IRS1 ELISA试剂盒)/PDPK1/AKT (显示 AKT1 ELISA试剂盒) insulin (显示 INS ELISA试剂盒) pathway by interacting with its GAP ASAP2 (显示 ASAP2 ELISA试剂盒) and activating PDPK1. This research may provide new insights into GTPase (显示 RACGAP1 ELISA试剂盒)-mediated insulin (显示 INS ELISA试剂盒) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS ELISA试剂盒) sensitizati
Only when suboptimal doses of Akt (显示 AKT1 ELISA试剂盒)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (显示 NOTCH1 ELISA试剂盒) inhibition was seen. We conclude that the Akt (显示 AKT1 ELISA试剂盒) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (显示 AKT1 ELISA试剂盒) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (显示 NFKB1 ELISA试剂盒).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.
PDK1 is an important regulator in arterial thrombosis formation.
The authors show that loss of frataxin homolog (fh (显示 FXN ELISA试剂盒)) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2 (显示 MYEF2 ELISA试剂盒)).
PDK1 is also a presynaptic protein, though it is distributed more broadly.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (显示 CDK7 ELISA试剂盒) 1, dPDK1
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (显示 PIK3C3 ELISA试剂盒) (PI3K)
Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.
3-phosphoinositide-dependent protein kinase 1
, 3-phosphoinositide dependent protein kinase-1
, pkB kinase
, protein kinase B kinase
, PkB kinase like gene 1
, Pkb kinase
, phosphoinositide dependent kinase 1
, phosphoinositide-dependent kinase 1
, protein kinase 61C
, serine/threonine protein kinase
, pyruvate dehydrogenase kinase 1
, pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial