PDPK1 (PDPK1) ELISA试剂盒产品概述

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3-phosphoinositide Dependent Protein Kinase-1 ELISA试剂盒 (PDPK1)
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别名:
1210, BG02759, CD79B, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, LOC100304995, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787

PDPK1 (PDPK1) ELISA试剂盒 by Reactivity

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Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (显示 CDK7 ELISA试剂盒) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (显示 IL1B ELISA试剂盒)pared to (显示 IL6 ELISA试剂盒)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (显示 RPS6KA3 ELISA试剂盒)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (显示 TNF ELISA试剂盒)gress of RA.

  3. PDK1 is required for Ca(2 (显示 CA2 ELISA试剂盒)+)-dependent platelet activation on stimulation of collagen receptor (显示 ITGA2 ELISA试剂盒) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (显示 INS ELISA试剂盒)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (显示 IRS1 ELISA试剂盒)/PDPK1/AKT (显示 AKT1 ELISA试剂盒) insulin (显示 INS ELISA试剂盒) pathway by interacting with its GAP ASAP2 (显示 ASAP2 ELISA试剂盒) and activating PDPK1. This research may provide new insights into GTPase (显示 RACGAP1 ELISA试剂盒)-mediated insulin (显示 INS ELISA试剂盒) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS ELISA试剂盒) sensitizati

  5. Only when suboptimal doses of Akt (显示 AKT1 ELISA试剂盒)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (显示 NOTCH1 ELISA试剂盒) inhibition was seen. We conclude that the Akt (显示 AKT1 ELISA试剂盒) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (显示 AKT1 ELISA试剂盒) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (显示 NFKB1 ELISA试剂盒).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (显示 BCR ELISA试剂盒)-induced signal transduction to Foxo (显示 FOXO3 ELISA试剂盒) and NF-kappaB (显示 NFKB1 ELISA试剂盒) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Highly expressed PDK1 (显示 PDK1 ELISA试剂盒) could promote cell invasion and secretion of IL-1beta (显示 IL1B ELISA试剂盒) and IL-6 (显示 IL6 ELISA试剂盒) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (显示 RPS6KA3 ELISA试剂盒) reduced the PDK1 (显示 PDK1 ELISA试剂盒)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (显示 TNF ELISA试剂盒), PDK1 (显示 PDK1 ELISA试剂盒) could phosphorylate RSK2 (显示 RPS6KA3 ELISA试剂盒) and activated RSK2 (显示 RPS6KA3 ELISA试剂盒), then promoting the activation of NF-kappaB (显示 NFKB1 ELISA试剂盒).

  2. In cancer cells resistant to PI3Kalpha (显示 PIK3CA ELISA试剂盒) inhibition, PDK1 (显示 PDK1 ELISA试剂盒) blockade restores sensitivity to these therapies. SGK1 (显示 SGK1 ELISA试剂盒), which is activated by PDK1 (显示 PDK1 ELISA试剂盒), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (显示 TSC2 ELISA试剂盒).

  3. Results suggest that Ser (显示 SIGLEC1 ELISA试剂盒)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (显示 PDK1 ELISA试剂盒)-PKCtheta (显示 PRKCQ ELISA试剂盒);-mediated T cell activation.

  4. Elevated expression of PDK1 (显示 PDK1 ELISA试剂盒) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (显示 MLXIP ELISA试剂盒)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (显示 PDK1 ELISA试剂盒).

  6. miR (显示 MLXIP ELISA试剂盒)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (显示 PDK1 ELISA试剂盒) expression.

  7. Decreased PDK1 (显示 PDK1 ELISA试剂盒) level is closely associated with reduced Akt (显示 AKT1 ELISA试剂盒)/cyclin D1 (显示 CCND1 ELISA试剂盒) activity.

  8. MiR (显示 MLXIP ELISA试剂盒)-138 regulation of PI3K (显示 PIK3CA ELISA试剂盒) signaling in ASMCs by altering the expression of PDK1 (显示 PDK1 ELISA试剂盒).

  9. Dephosphorylation of PDK-1 (显示 PDK1 ELISA试剂盒) and the resulting changes to Akt (显示 AKT1 ELISA试剂盒) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (显示 CLDN18 ELISA试剂盒) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (显示 CDK7 ELISA试剂盒)-1 and proto-oncogene (显示 RAB1A ELISA试剂盒) protein c (显示 PROC ELISA试剂盒)-akt (Akt (显示 AKT1 ELISA试剂盒)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (显示 MYLIP ELISA试剂盒)-375 directly targeted PDK1 (显示 PDK1 ELISA试剂盒) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (显示 PIK3C3 ELISA试剂盒) (PI3K)

PDPK1 抗原简介

Antigen Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • Phosphoinositide-dependent kinase 1 (Pdk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) Elisa Kit
  • CD79b molecule, immunoglobulin-associated beta (CD79B) Elisa Kit
  • CD79b molecule, immunoglobulin-associated beta (CD79b) Elisa Kit
  • CD79b (LOC100304995) Elisa Kit
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) Elisa Kit
  • Protein PDK-1 (pdk-1) Elisa Kit
  • 1210 Elisa Kit
  • BG02759 Elisa Kit
  • CD79B Elisa Kit
  • CG1201 Elisa Kit
  • CG1210 Elisa Kit
  • Dmel\\CG1210 Elisa Kit
  • dPDK-1 Elisa Kit
  • dPDK1 Elisa Kit
  • dSTPK61 Elisa Kit
  • LOC100304995 Elisa Kit
  • MGC82080 Elisa Kit
  • PDK Elisa Kit
  • PDK-1 Elisa Kit
  • Pdk1 Elisa Kit
  • PDK1/Pk61C Elisa Kit
  • pdpk1 Elisa Kit
  • PDPK2 Elisa Kit
  • pk61c Elisa Kit
  • Pk61C/PDK1 Elisa Kit
  • PRO0461 Elisa Kit
  • zgc:153787 Elisa Kit

Protein level used designations for PDPK1

CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase , 3-phosphoinositide dependent protein kinase-1 , 3-phosphoinositide-dependent protein kinase 1 , B-cell antigen receptor complex-associated protein beta chain , CD79b molecule, immunoglobulin-associated beta , CD79b , Pkb kinase , mPDK1 , PkB kinase like gene 1 , pkB kinase , protein kinase B kinase

GENE ID SPECIES
38017 Drosophila melanogaster
444529 Xenopus laevis
779524 Xenopus (Silurana) tropicalis
768202 Danio rerio
419940 Gallus gallus
454773 Pan troglodytes
100026330 Monodelphis domestica
100304995 Ictalurus punctatus
100471131 Ailuropoda melanoleuca
100380750 Salmo salar
18607 Mus musculus
5170 Homo sapiens
81745 Rattus norvegicus
100192445 Sus scrofa
416588 Gallus gallus
479875 Canis lupus familiaris
100138102 Bos taurus
180475 Caenorhabditis elegans
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