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Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (显示 CDK2AP1 ELISA试剂盒)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 (显示 MBD3 ELISA试剂盒) to the promoter region of Wnt (显示 WNT2 ELISA试剂盒) signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒) partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
Here, we introduce a transcriptional signature to specifically track CDK2 (显示 CDK2 ELISA试剂盒) activity. It responds to genetic and chemical perturbations in the CDK (显示 CDK4 ELISA试剂盒)-RB-E2F (显示 E2F1 ELISA试剂盒) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (显示 CDK2 ELISA试剂盒) activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (显示 Cep76 ELISA试剂盒)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2 (显示 CDK2 ELISA试剂盒)) and is a bona fide substrate of this kinase. Cep76 (显示 Cep76 ELISA试剂盒) is preferentially phosphorylated by cyclin A (显示 CCNA2 ELISA试剂盒)/CDK2 (显示 CDK2 ELISA试剂盒) at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (显示 SPDYA ELISA试剂盒) confers structural changes to Cdk2 (显示 CDK2 ELISA试剂盒) that obviate the requirement of Cdk (显示 CDK4 ELISA试剂盒) activation loop phosphorylation.
CDK2 (显示 CDK2 ELISA试剂盒) serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
Date show that when Wee1 (显示 WEE1 ELISA试剂盒) alone is inhibited, Chk1 (显示 CHEK1 ELISA试剂盒) suppresses CDC45 loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (显示 CDK4 ELISA试剂盒)-activity.
Results show that cyclin E1 (显示 CCNE1 ELISA试剂盒) and CDK2 (显示 CDK2 ELISA试剂盒) participate in STC1 (显示 STC1 ELISA试剂盒) promoting cell proliferation of prostate neoplasm cells.
The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 (显示 CDK2 ELISA试剂盒) disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (显示 CDK1 ELISA试剂盒) inhibition.
periodic phosphorylation of Ku70 (显示 XRCC6 ELISA试剂盒) by cyclin-cyclin (显示 PCNA ELISA试剂盒) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 (显示 CDK2 ELISA试剂盒) binding, and attenuated E2F-1 (显示 E2F1 ELISA试剂盒) sequestration.
These two states are separated by different metastable states that share hybrid structural features with both forms of the kinase. In contrast, the CDK2/ANS complex landscape is compatible with a conformational selection picture where the binding of ANS in proximity of the alphaC helix causes a population shift toward the inactive conformation
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
cyclin-dependent kinase 2-associated protein 2
, DOC-1 related protein
, DOC-1-related protein
, cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, CDK2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1