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Human Polyclonal FBXL3 Primary Antibody for ELISA, WB - ABIN251670
Korge, Grudziecki, Kramer: Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells. in Journal of biological rhythms 2015
Show all 2 Pubmed References
These results demonstrate that CRY2 (显示 CRY2 抗体) stability controlled by FBXL3 plays a key role in the regulation of human sleep wake behavior.
CRY2 (显示 CRY2 抗体) and FBXL3 cooperatively degrade c-MYC (显示 MYC 抗体) preventing the development of cancer.
Data show that CRISPR/Cas9 genome editing generated F-box and leucine-rich repeat protein 3 (Fbxl3) knockout in circadian clock model U2OS cells.
Substrate binding promotes formation of the Skp1 (显示 SKP1 抗体)-Cul1 (显示 CUL1 抗体)-Fbxl3 (SCF (显示 KITLG 抗体)(Fbxl3)) protein complex.
Mutation in the Fbxl3 protein reveals distinct roles for CRY1 (显示 CRY1 抗体) and CRY2 (显示 CRY2 抗体) in the circadian molecular clockwork.
crystal structures of mammalian CRY2 (显示 CRY2 抗体) in its apo (显示 C9orf3 抗体), FAD (显示 BRCA2 抗体)-bound and FBXL3-SKP1 (显示 SKP1 抗体)-complexed forms
study demonstrates that the SCF (显示 KITLG 抗体)(Fbxl3)ubiquitin ligase controls the oscillations of the circadian clock by mediating the degradation of Cry1 (显示 CRY1 抗体) and Cry2 (显示 CRY2 抗体) proteins
By analyzing the Fbxl3 and Cryptochrome 1 (显示 CRY1 抗体) double-mutant mice, we found that FBXL3 also regulates the amplitudes of E-box-driven gene expression.
crystal structures of mammalian CRY2 (显示 CRY2 抗体) in its apo (显示 C9orf3 抗体), FAD (显示 FANCD2 抗体)-bound and FBXL3-SKP1 (显示 SKP1 抗体)-complexed forms
FBXL21 (显示 FBXL21 抗体) plays a dual role: protecting CRY 1 (显示 CRY1 抗体)/2 proteins (CRY (显示 CRY2 抗体)) from FBXL3 degradation in the nucleus and promoting CRY (显示 CRY2 抗体) degradation within the cytoplasm.
results are consistent with previous studies of mutants with extended circadian periods and suggest that disruption of FBXL3 is associated with mania-like behaviours in both mice and humans
In Ovtm mice, expression of the PERIOD proteins is reduced; however, the CRY (显示 CRY2 抗体) proteins are unchanged; the loss of FBXL3 function leads to a stabilization of the CRY (显示 CRY2 抗体) proteins, which leads to a global transcriptional repression of the Per and Cry (显示 CRY2 抗体) genes.
study demonstrates that the SCF (显示 KITLG 抗体)(Fbxl3)ubiquitin ligase (显示 RNF123 抗体) controls the oscillations of the circadian clock by mediating the degradation of Cry1 (显示 CRY1 抗体) and Cry2 (显示 CRY2 抗体) proteins
studies reveal a central role for Fbxl3 in mammalian circadian timekeeping
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.
F-box and leucine-rich repeat protein 3
, F-box/LRR-repeat protein 3
, F-box/LRR-repeat protein 3-like
, f-box/LRR-repeat protein 3-like
, similar to F-box and leucine-rich repeat protein 8
, F-box and leucine-rich repeat protein 3A
, F-box protein Fbl3a
, F-box/LRR-repeat protein 3A
, F-box and leucine-rich repeat protein 3a
, protein after-hours
, protein overtime