This is a synthetic peptide designed for use in combination with anti-NKIRAS1 antibody (Catalog #: ARP55370_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
NKIRAS1 is an atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. NKIRAS1 may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Alias Symbols: KBRAS1, kappaB-Ras1
Protein Interaction Partner: ACVR1,BMPR1B,NFKBIA,NFKBIB,SMURF2,TGFBR1,NFKBIB