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Human JAG1 ELISA Kit for Sandwich ELISA - ABIN417745
Zeng, Jin, Ao, Cleveland, Song, Xu, Fullerton, Meng: Cross-talk between the Toll-like receptor 4 and Notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. in Circulation 2012
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Jagged-1 induces cell growth inhibition and S phase cell cycle arrest in prostate cancer cells.
Data indicate that jagged 1 protein (JAG1)-mediated Notch (显示 NOTCH1 ELISA试剂盒) signaling regulates differentiation of basal cells (BC) into secretory cells.
these results show that the Notch (显示 NOTCH1 ELISA试剂盒) signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 (显示 JAG2 ELISA试剂盒) on DCs is not required
Bruceine D inhibits hepatocellular carcinoma growth by targeting beta-catenin/jagged1 signaling pathways.
Results showed that JAG1 was significantly downregulated in miR (显示 MLXIP ELISA试剂盒)-26a-overexpressing osteosarcoma cells and is a direct target of miR (显示 MLXIP ELISA试剂盒)-26a.
the effects of two Notch (显示 NOTCH1 ELISA试剂盒) ligands, i.e., Jagged1 and DLL1 (显示 DLL1 ELISA试剂盒), on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (显示 NOTCH1 ELISA试剂盒) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Specific Notch3 (显示 NOTCH3 ELISA试剂盒) and Jag1 subcellular localization patterns may provide clues for the behavior of the corresponding tumors and could potentially be applied in the clinic for Jag1 targeting in triple-negative breast cancer patients.
there is a cross-talk between Jagged1/Notch3 (显示 NOTCH3 ELISA试剂盒) and VEGF (显示 VEGFA ELISA试剂盒) in TNBC angiogenesis. Jagged1/Notch3 (显示 NOTCH3 ELISA试剂盒) is expected to be an important signaling pathway for TNBC progression and a potential target for TNBC neovascularization therapy.
Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
Notch (显示 NOTCH1 ELISA试剂盒) signaling in ECs was induced by cocultures of ECs with tumor cells expressing the Notch (显示 NOTCH1 ELISA试剂盒) ligands DLL4 (显示 DLL4 ELISA试剂盒) and JAG1 in vitro, and NICD (显示 NOTCH1 ELISA试剂盒) expression was induced in ECs by tumor-infiltrating myeloid cells in vivo
pre-coated Notch1 (显示 NOTCH1 ELISA试剂盒) protein promotes Notch1 (显示 NOTCH1 ELISA试剂盒)-knocked down B cells to produce antibody in LPS (显示 TLR4 ELISA试剂盒)-stimulated B cells suggesting that Notch1 (显示 NOTCH1 ELISA试剂盒) in other cells may promote antibody production by binding its ligands Dll1 (显示 DLL1 ELISA试剂盒) and Jag1 in B cells.
JAG1 is the main activator of NOTCH signaling and GDNF expression in Sertoli cells.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
A Jagged1-Hey1 (显示 HEY1 ELISA试剂盒) signal might mediate the impairment of angiogenesis induced by Ang II (显示 AGT ELISA试剂盒) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (显示 STAT3 ELISA试剂盒) by physical binding, and nuclear STAT3 (显示 STAT3 ELISA试剂盒) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (显示 GDF9 ELISA试剂盒) and BMP15 (显示 BMP15 ELISA试剂盒).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (显示 NOTCH1 ELISA试剂盒) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1