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An intracellular pool of LFA-1 (显示 ITGAL ELISA试剂盒) in naive CD8 (显示 CD8A ELISA试剂盒)(+) T cells plays a key role in T cell activation and differentiation.
Extracellular ISG15 (显示 ISG15 ELISA试剂盒) signals cytokine secretion through the LFA-1 (显示 ITGAL ELISA试剂盒) integrin receptor (CD11a (显示 ITGAL ELISA试剂盒)/CD18) in natural killer cells.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (显示 CA5A ELISA试剂盒))1in membrane organization and beta2 integrin Lfa1 (显示 ITGAL ELISA试剂盒) function in primary CD8 (显示 CD8A ELISA试剂盒) T cells.
Coro1A (显示 CORO1A ELISA试剂盒) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
EAE induced by weak activation of innate immunity requires the NLRP3 inflamma (显示 CXCR4 ELISA试剂盒)some and (显示 CXCR2 ELISA试剂盒)is sensitive to interferon-beta treatment
These results identify CD47 (显示 CD47 ELISA试剂盒) as an important regulator of LFA-1 (显示 ITGAL ELISA试剂盒) and VLA-4 integrin-adhesive functions in T cell proliferation.
lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7 (显示 IL7 ELISA试剂盒); the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (显示 LTB ELISA试剂盒) (LT)betaR signaling
both GDF-15 (显示 GDF15 ELISA试剂盒) and TGF-beta1 (显示 TGFB1 ELISA试剂盒) counteract chemokine (显示 CCL1 ELISA试剂盒)-induced integrin activation on neutrophils via the ALK-5 (显示 TGFBR1 ELISA试剂盒)/TGF-betaRII heterodimer.
the Slam (显示 SLAMF1 ELISA试剂盒) locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4 (显示 CD244 ELISA试剂盒). This effect is influenced by cytokines and leads to suppression of LFA-1 (显示 ITGAL ELISA试剂盒) activity.
Neutrophil rolling over E-selectin (显示 SELE ELISA试剂盒) at precise shear stress transmits tension and catch-bond formation with L-selectin (显示 SELL ELISA试剂盒) via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit
CD177 (显示 CD177 ELISA试剂盒) signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration.
findings suggest the partitioning in soluble CD18 to reflect a compensatory anti-inflammatory response syndrome and hyperinflammation, respectively, manifested as part of sepsis.
activation of LFA-1 (显示 ITGAL ELISA试剂盒) (alphaLbeta2) and Mac-1 (显示 ITGAM ELISA试剂盒) (alphaMbeta2), two subfamilies of integrin beta2 complexes, on human primary monocytes following platelet releasate treatment
membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor (显示 CXCR4 ELISA试剂盒) 2 (CXCR2 (显示 CXCR2 ELISA试剂盒)), is involved in type B EAE development
data suggest that regulation of LFA-1 (显示 ITGAL ELISA试剂盒) is one reason for the different activity of NK cells during differentiation
The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (显示 SIGLEC1 ELISA试剂盒) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (显示 YWHAZ ELISA试剂盒) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling
this study shows that cross-talk between LFA-1 (显示 ITGAL ELISA试剂盒) and Notch1 (显示 NOTCH1 ELISA试剂盒) through the Akt (显示 AKT1 ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒)-GSK3beta (显示 GSK3b ELISA试剂盒) signaling enhances T cell differentiation toward Th1 (显示 TH1L ELISA试剂盒)
FRbeta (显示 FOLR2 ELISA试剂盒) as a novel CD11b/CD18 (显示 ITGAM ELISA试剂盒) regulator for trafficking and homing of a subset of macrophages on collagen.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (显示 SELL ELISA试剂盒) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (显示 CA2 ELISA试剂盒)+]i, diminished annexin V (显示 ANXA5 ELISA试剂盒) expression on the cell surface, and decreased caspase 3 (显示 CASP3 ELISA试剂盒) activity in lysates
The I-EGF (显示 EGF ELISA试剂盒)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (显示 ORM1 ELISA试剂盒) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (显示 POLG ELISA试剂盒) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (显示 ITGAM ELISA试剂盒) plays a cardinal (显示 CARD8 ELISA试剂盒) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (显示 ZP3 ELISA试剂盒) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (显示 IRF6 ELISA试剂盒) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (显示 ITGAX ELISA试剂盒)/CD18 alpha-chain (显示 FCGRT ELISA试剂盒) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)