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striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (显示 Ralb ELISA试剂盒).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (显示 GRIN1 ELISA试剂盒)-long-term depression.
findings show either RALA or RALB (显示 Ralb ELISA试剂盒) is sufficient for tumor growth; either RALA or RALB (显示 Ralb ELISA试剂盒) is sufficient for cell proliferation; RALA and RALB (显示 Ralb ELISA试剂盒) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (显示 PPP1R3A ELISA试剂盒), RGC2 (显示 RALGAPA2 ELISA试剂盒)) that mediates the activation of RalA downstream of the PI 3 (显示 PI3 ELISA试剂盒)-kinase/Akt (显示 AKT1 ELISA试剂盒) pathway
A novel regulatory pathway involves RalA and phospholipase D (显示 PLD ELISA试剂盒) in the production of phosphatidic acid during Fc gamma receptor (显示 FCGR1A ELISA试剂盒)-mediated phagocytosis and phagosome formation.
RalA but not RalB (显示 Ralb ELISA试剂盒) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (显示 RALGDS ELISA试剂盒) in response to a rise in intracellular Ca2 (显示 CA2 ELISA试剂盒)+ and cAMP controls hormone release from pancreatic beta-cells
RalA is activated by H-Ras (显示 HRAS ELISA试剂盒), which along with ARF6 (显示 ARF6 ELISA试剂盒), leads to phospholipase D (显示 PLD ELISA试剂盒) activation
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R and D3R, through GRK2 and beta-arrestins, respectively. Active RalA was found to interact with GRK2 to sequester it from D2R. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
results suggest that the small GTPase (显示 RACGAP1 ELISA试剂盒) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (显示 CAV1 ELISA试剂盒) and FilA but by stimulating PLD2 (显示 PLD2 ELISA试剂盒)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (显示 AK3 ELISA试剂盒)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (显示 RACGAP1 ELISA试剂盒) RalA. RCC2 and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
expression of K-Ras (显示 HRAS ELISA试剂盒) and RalB (显示 Ralb ELISA试剂盒) and possibly RalA proteins is critical for maintaining low levels of p53 (显示 TP53 ELISA试剂盒), and down-regulation of these GTPases reactivates p53 (显示 TP53 ELISA试剂盒) by significantly enhancing its stability, contributing to suppression of malignant transformation
These results indicate that MLN8237 treatment may be effective for a subset of patients with PDAC independent of RalA S194 phosphorylation
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 (显示 SOX9 ELISA试剂盒) and ACAN (显示 ACAN ELISA试剂盒).
Data show that small GTPase (显示 RACGAP1 ELISA试剂盒) RALA regulates formation of a JIP1 (显示 MAPK8IP1 ELISA试剂盒) (C-Jun (显示 JUN ELISA试剂盒)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (显示 MAPK8 ELISA试剂盒) signaling toward FOXO4 (显示 FOXO4 ELISA试剂盒) (forkhead box O transcription factor) in response to reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒)).
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A