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we discovered one novel locus (LRP2 (显示 LRP2 ELISA试剂盒); most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR (显示 MLXIP ELISA试剂盒)-148b directly down-regulates renal megalin (显示 LRP2 ELISA试剂盒) expression.
Exocytosis-mediated urinary C-megalin (显示 LRP2 ELISA试剂盒) excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin (显示 LRP2 ELISA试剂盒)-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin (显示 LRP2 ELISA试剂盒)/cubilin (显示 CUBN ELISA试剂盒) ligands, hemoglobin (显示 HBB ELISA试剂盒) and albumin (显示 ALB ELISA试剂盒), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
VDR (显示 CYP27B1 ELISA试剂盒) and MEGALIN (显示 LRP2 ELISA试剂盒) gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.
the main role for placental megalin (显示 LRP2 ELISA试剂盒) is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin (显示 LRP2 ELISA试剂盒) in the cytotrophoblasts.
specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2 (显示 LRP2 ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) pathway
abundances of megalin (显示 LRP2 ELISA试剂盒) and Dab2 (显示 DAB2 ELISA试剂盒) (p = 0.046) were reduced in infected placentas from women with LBW deliveries
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (显示 LRP2 ELISA试剂盒) and TSPYL2 (显示 TSPYL2 ELISA试剂盒) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis.
the PH domain of Dbs has a role in regulating Rho GTPase (显示 RACGAP1 ELISA试剂盒) activation
the PH domain of Dbs has two roles in the regulation of DH domain function, one for GTPase (显示 RACGAP1 ELISA试剂盒) association and activation in vitro and one for phosphoinositide binding and GTPase (显示 RACGAP1 ELISA试剂盒) interaction in vivo, that together promote Dbs association with membranes.
Dbs is activated by Rac1 at the pleckstrin (显示 PLEK ELISA试剂盒) homology domain
Dbs has the potential to promote proliferation of immature thymocytes, but also sensitizes immature thymocytes to deletion.
Crystal structure of the DH/PH fragment of Dbs without bound GTPase (显示 RACGAP1 ELISA试剂盒)
the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein
Dbs transformation is associated with increased phosphorylation of myosin light chain and stress fiber formation, both of which occur in a ROCK-dependent manner
oncogene that can activate small GTP-binding proteins
DBL's big sister
, MCF2 transforming sequence-like protein
, guanine nucleotide exchange factor DBS
, MCF2-transforming sequence-like protein
, OST oncogene
, mcf.2 transforming sequence-like
, MCF.2 cell line derived transforming sequence-like
, coagulation factor VII
, guanine nucleotide exchange factor DBS-like
, Ost gamma
, exchange factor for RhoA and Cdc42
, guanine nucleotide exchange factor OSTIII