Use your antibodies-online credentials, if available.
Select your species
SNX3 (显示 SNX3 ELISA试剂盒)-retromer complex regulates the surface expression and function of PC1 (显示 PCSK1 ELISA试剂盒) and PC2 (显示 KRT6B ELISA试剂盒)
Study identified a novel heterozygous frameshift mutation in PKD1 gene segregating between affected and unaffected individuals suggesting an involvement in polycystic kidney disease (PKD (显示 PRKD1 ELISA试剂盒)).
we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 (显示 FRS2 ELISA试剂盒) as a novel mediator of androgen-induced PKD1 repression.
Hyperactivation of the ERK (显示 EPHB2 ELISA试剂盒) pathway may be caused by down-regulation of PC-1 (显示 PCSK1 ELISA试剂盒) and PC-2 (显示 KRT6B ELISA试剂盒) in lymphatic malformations, contributing to increased proliferation of lymphatic endothelial cells.
A novel mutation of the PKD1 gene has been identified with autosomal dominant polycystic kidney disease in an affected Chinese family.
Annualized median liver growth rates were 1.68, 1.5 and 1.24% for PKD1-T, PKD1-NT and PKD2 (显示 PKD2 ELISA试剂盒) mutations, respectively (P = 0.49), and remained unaffected by the ADPKD genotype when adjusted for age, gender and baseline HtLV.
this study shows that diet-induced obesity links to estrogen receptor (显示 ESR1 ELISA试剂盒)-positive breast cancer progression via LPA (显示 APOA ELISA试剂盒)/PKD-1-CD36 (显示 CD36 ELISA试剂盒) signaling-mediated microvascular remodeling
Isolated polycystic liver disease genes define effectors of polycystin-1 function
mechanical load upregulates expression of Runx2 (显示 RUNX2 ELISA试剂盒) gene via potentiation of PC1 (显示 PCSK1 ELISA试剂盒)-JAK2 (显示 JAK2 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.
Gly972Arg of PC-1 (显示 PCSK1 ELISA试剂盒) polymorphisms are associated with polycystic ovary syndrome.
PC1/3 (显示 PCSK1 ELISA试剂盒) deficiency was associated with increased expression of melanocortin receptors and PRCP (prolylcarboxypeptidase (显示 PRCP ELISA试剂盒), a catabolic enzyme for alpha-melanocyte stimulating hormone (alphaMSH (显示 POMC ELISA试剂盒))), and reduced adrenocorticotropic hormone secretion. We conclude that the obesity accompanying PCSK1 (显示 PCSK1 ELISA试剂盒) deficiency may not be primarily due to alphaMSH (显示 POMC ELISA试剂盒) deficiency.
Mutations in PKD1 is associated with autosomal dominant polycystic kidney disease.
critical functions of PC1 are regulated by its ability to sense cytosolic calcium levels via binding to calmodulin
cortactin (显示 CTTN ELISA试剂盒) binds to E-cadherin (显示 CDH1 ELISA试剂盒), and that a posttranslational modification of cortactin (显示 CTTN ELISA试剂盒), RhoA (显示 RHOA ELISA试剂盒)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (显示 PRKD1 ELISA试剂盒)) at S298, impairs adherens junction assembly and supports their dissolution.
Galpha12 (显示 GNA12 ELISA试剂盒) is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
kd1 mutant mice have transcriptional profiles consistent with changes in lipid metabolism and distinct metabolite and complex lipid profiles in kidneys. .. cells lacking Pkd1 have an intrinsic fatty acid oxidation defect and that manipulation of lipid content of mouse chow modifies cystic disease.
Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected
detected a marked increase in the localization of beta-catenin (显示 CTNNB1 ELISA试剂盒) in the nucleus of crypt epithelial cells in the ileum of PKD1
PKD1 phosphorylates AMPKalpha2 (显示 PRKAA2 ELISA试剂盒) at Ser485/491, thus diminishing AMPK (显示 PRKAA1 ELISA试剂盒) activity.
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
autosomal dominant polycystic kidney disease 1 protein
, polycystic kidney disease-associated protein
, polycystin 1
, transient receptor potential cation channel, subfamily P, member 1
, autosomal dominant polycystic kidney disease 1 protein homolog
, polycystic kidney disease 1 homolog; polycystin-1
, polycystic kidney disease 1 (autosomal dominant)
, polycystic kidney disease protein 1