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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) 抗体产品概述

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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) 抗体 (PKD1)
在www.antibodies-online.cn可供57 Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) 抗体的10不同的供货商。 再加上,我们可以发Polycystic Kidney Disease 1 (Autosomal Dominant) 试剂盒 (6)Polycystic Kidney Disease 1 (Autosomal Dominant) 蛋白 (4)和数多这个蛋白质的别的产品。 总共69 Polycystic Kidney Disease 1 (Autosomal Dominant)产品已列进来了。
别名:
mFLJ00285, PBP, Pc-1, PC1, Pkcm, PKD, PKD1, Prkcm, TRPP1

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引用最多的anti-Polycystic Kidney Disease 1 (Autosomal Dominant) 抗体

  1. Human Polyclonal PKD1 Primary Antibody for IF (p), IHC (p) - ABIN678083 : Chiou, Sang, Cheng, Ho, Wang, Pan: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. in Carcinogenesis 2013 (PubMed)
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更多抗Polycystic Kidney Disease 1 (Autosomal Dominant)的相互作用对抗体

Human Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. PKD1 mutation is associated with familial testicular germ cell tumor and autosomal dominant polycystic kidney disease.

  2. we have quantified the contribution of genic and PKD1 allelic effects and sex to the Autosomal dominant polycystic kidney disease phenotype. Intrafamilial correlation analysis showed that other factors shared by families influence height-adjusted total kidney volume, with these additional genetic/environmental factors significantly affecting the Autosomal dominant polycystic kidney disease phenotype

  3. The epithelial cell membrane protein E (显示 CRISP1 抗体)-cadherin (显示 CDH1 抗体) physically binds to PKD1 which leads to a subcellular redistribution of PKD1.

  4. PKD1 and PKD2 (显示 PKD2 抗体) are susceptibility genes for familial intracranial aneurysms in a Japanese population.

  5. These results suggest that the Ser (显示 SIGLEC1 抗体) at the 4166 site in PC1 (显示 PCSK1 抗体) is crucial in the PC1 (显示 PCSK1 抗体) mediated MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体)/myc (显示 MYC 抗体) signaling pathway, which might be the key pathophysiological cause of Aortic dissection.

  6. Novel PKD1 mutations in Chinese autosomal dominant polycystic kidney disease patients

  7. The pathogenic mutation in PKD1 linked pedigree was c.8522G>A (p.E2771K) in exon 23. This C to T transition occurs at the CpG dinucleotides which is the known hotspot point for mutations.

  8. Germline mutations in PKD1 gene is associated with autosomal-dominant polycystic kidney disease.

  9. Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.

  10. PCs expression and p53 (显示 TP53 抗体) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.

Mouse (Murine) Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.

  2. Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7 (显示 HDAC7 抗体), where it interacts with forkhead box protein O1 (显示 FOXO1 抗体) to suppress endothelial CD36 (显示 CD36 抗体) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.

  3. kd1 mutant mice have transcriptional profiles consistent with changes in lipid metabolism and distinct metabolite and complex lipid profiles in kidneys. .. cells lacking Pkd1 have an intrinsic fatty acid oxidation defect and that manipulation of lipid content of mouse chow modifies cystic disease.

  4. Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected

  5. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (显示 DGKA 抗体) effect on MVB secretory traffic.

  6. detected a marked increase in the localization of beta-catenin (显示 CTNNB1 抗体) in the nucleus of crypt epithelial cells in the ileum of PKD1

  7. PKD1 phosphorylates AMPKalpha2 (显示 PRKAA2 抗体) at Ser485/491, thus diminishing AMPK (显示 PRKAA1 抗体) activity.

  8. These data potentially explain the severe renal manifestations of the tuberous sclerosis/polycystic kidney disease contiguous gene syndrome and open new perspectives for the use of mTOR (显示 FRAP1 抗体) inhibitors in PKD (显示 PRKD1 抗体).

  9. Our results show that AKAP13 (显示 AKAP13 抗体)-PKD1 signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.

  10. PKD1 acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (显示 NOTCH1 抗体) pathway.

Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) 抗原简介

Antigen Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Alternative names and synonyms associated with Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1)

  • polycystic kidney disease 1 (autosomal dominant) (PKD1) 抗体
  • polycystic kidney disease 1 homolog (Pkd1) 抗体
  • polycystic kidney disease 1 homolog (human) (Pkd1) 抗体
  • protein kinase D1 (Prkd1) 抗体
  • mFLJ00285 抗体
  • PBP 抗体
  • Pc-1 抗体
  • PC1 抗体
  • Pkcm 抗体
  • PKD 抗体
  • PKD1 抗体
  • Prkcm 抗体
  • TRPP1 抗体

Protein level used designations for PKD1

polycystic kidney disease 1 (autosomal dominant) , polycystin 1 , autosomal dominant polycystic kidney disease 1 protein , polycystic kidney disease-associated protein , polycystin-1 , transient receptor potential cation channel, subfamily P, member 1 , polycystic kidney disease protein 1 , autosomal dominant polycystic kidney disease 1 protein homolog , polycystic kidney disease 1 homolog; polycystin-1 , nPKC-D1 , nPKC-mu , protein kinase C mu type , protein kinase C, mu , protein kinase D , serine/threonine-protein kinase D1

GENE ID SPECIES
416553 Gallus gallus
749291 Pan troglodytes
5310 Homo sapiens
606755 Canis lupus familiaris
100516429 Sus scrofa
18763 Mus musculus
24650 Rattus norvegicus
18760 Mus musculus
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