anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) 抗体产品概述

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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) 抗体 (PKD1)
在www.antibodies-online.cn可供59 Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) 抗体的12不同的供货商。 再加上,我们可以发Polycystic Kidney Disease 1 (Autosomal Dominant) 试剂盒 (7)Polycystic Kidney Disease 1 (Autosomal Dominant) 蛋白 (4)和数多这个蛋白质的别的产品。 总共72 Polycystic Kidney Disease 1 (Autosomal Dominant)产品已列进来了。
别名:
mFLJ00285, PBP, Pc-1, PC1, Pkcm, PKD, PKD1, Prkcm, TRPP1

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  1. Human Polyclonal PKD1 Primary Antibody for IF (p), IHC (p) - ABIN678083 : Chiou, Sang, Cheng, Ho, Wang, Pan: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. in Carcinogenesis 2013 (PubMed)
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更多抗Polycystic Kidney Disease 1 (Autosomal Dominant)的相互作用对抗体

Human Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. A novel mutation of the PKD1 gene has been identified with autosomal dominant polycystic kidney disease in an affected Chinese family.

  2. Annualized median liver growth rates were 1.68, 1.5 and 1.24% for PKD1-T, PKD1-NT and PKD2 (显示 PKD2 抗体) mutations, respectively (P = 0.49), and remained unaffected by the ADPKD genotype when adjusted for age, gender and baseline HtLV.

  3. this study shows that diet-induced obesity links to estrogen receptor (显示 ESR1 抗体)-positive breast cancer progression via LPA (显示 APOA 抗体)/PKD-1-CD36 (显示 CD36 抗体) signaling-mediated microvascular remodeling

  4. Isolated polycystic liver disease genes define effectors of polycystin-1 function

  5. mechanical load upregulates expression of Runx2 (显示 RUNX2 抗体) gene via potentiation of PC1 (显示 PCSK1 抗体)-JAK2 (显示 JAK2 抗体)/STAT3 (显示 STAT3 抗体) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.

  6. Gly972Arg of PC-1 (显示 PCSK1 抗体) polymorphisms are associated with polycystic ovary syndrome.

  7. cortactin (显示 CTTN 抗体) binds to E-cadherin (显示 CDH1 抗体), and that a posttranslational modification of cortactin (显示 CTTN 抗体), RhoA (显示 RHOA 抗体)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (显示 PRKD1 抗体)) at S298, impairs adherens junction assembly and supports their dissolution.

  8. Ten novel mutations in PKD1 gene were identified in 15 Chinese families with polycystic kidney disease.

  9. PKD1 mutations are associated with autosomal dominant polycystic kidney disease.

  10. The novel PKD1 c.8791+1_8791+5delGTGCG mutation has created a new splice site.

Mouse (Murine) Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. critical functions of PC1 (显示 PCSK1 抗体) are regulated by its ability to sense cytosolic calcium levels via binding to calmodulin (显示 Calm2 抗体)

  2. cortactin (显示 CTTN 抗体) binds to E-cadherin (显示 CDH1 抗体), and that a posttranslational modification of cortactin (显示 CTTN 抗体), RhoA (显示 RHOA 抗体)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (显示 PRKD1 抗体)) at S298, impairs adherens junction assembly and supports their dissolution.

  3. Galpha12 (显示 GNA12 抗体) is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.

  4. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.

  5. Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7 (显示 HDAC7 抗体), where it interacts with forkhead box protein O1 (显示 FOXO1 抗体) to suppress endothelial CD36 (显示 CD36 抗体) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.

  6. kd1 mutant mice have transcriptional profiles consistent with changes in lipid metabolism and distinct metabolite and complex lipid profiles in kidneys. .. cells lacking Pkd1 have an intrinsic fatty acid oxidation defect and that manipulation of lipid content of mouse chow modifies cystic disease.

  7. Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected

  8. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (显示 DGKA 抗体) effect on MVB secretory traffic.

  9. detected a marked increase in the localization of beta-catenin (显示 CTNNB1 抗体) in the nucleus of crypt epithelial cells in the ileum of PKD1

  10. PKD1 phosphorylates AMPKalpha2 (显示 PRKAA2 抗体) at Ser485/491, thus diminishing AMPK (显示 PRKAA1 抗体) activity.

Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) 抗原简介

Antigen Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Alternative names and synonyms associated with Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1)

  • polycystic kidney disease 1 (autosomal dominant) (PKD1) 抗体
  • polycystic kidney disease 1 homolog (Pkd1) 抗体
  • polycystic kidney disease 1 homolog (human) (Pkd1) 抗体
  • protein kinase D1 (Prkd1) 抗体
  • mFLJ00285 抗体
  • PBP 抗体
  • Pc-1 抗体
  • PC1 抗体
  • Pkcm 抗体
  • PKD 抗体
  • PKD1 抗体
  • Prkcm 抗体
  • TRPP1 抗体

Protein level used designations for PKD1

polycystic kidney disease 1 (autosomal dominant) , polycystin 1 , autosomal dominant polycystic kidney disease 1 protein , polycystic kidney disease-associated protein , polycystin-1 , transient receptor potential cation channel, subfamily P, member 1 , polycystic kidney disease protein 1 , autosomal dominant polycystic kidney disease 1 protein homolog , polycystic kidney disease 1 homolog; polycystin-1 , nPKC-D1 , nPKC-mu , protein kinase C mu type , protein kinase C, mu , protein kinase D , serine/threonine-protein kinase D1

GENE ID SPECIES
416553 Gallus gallus
749291 Pan troglodytes
5310 Homo sapiens
606755 Canis lupus familiaris
100516429 Sus scrofa
18763 Mus musculus
24650 Rattus norvegicus
18760 Mus musculus
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