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OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation
Oxtr (显示 OXTR ELISA试剂盒) signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Nos1 (显示 NOS1 ELISA试剂盒) neurons of paraventricular nucleus of the hypothalamus promote negative energy balance through changes in feeding and energy expenditure, whereas OXT neurons regulate energy expenditure alone.
Data suggest that oxytocin plays a crucial role in the sexual behavior display, number of released oocytes and density of dendritic spines in the MePD (显示 THOP1 ELISA试剂盒) of female mice without affecting AVP (显示 AVP ELISA试剂盒) plasma concentration
lactic acid microbes accelerate wound healing via the neuropeptide hormone oxytocin
CD38 in the nucleus accumbens and oxytocin are critical in paternal behavior.
the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT (显示 DDC ELISA试剂盒) in the nucleus accumbens--with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders like autism
medial amygdala likely modulates hostile aggressive behavior associated with immediate early (显示 JUN ELISA试剂盒) gene expression in OXT and vasopressin (显示 AVP ELISA试剂盒) neurons
these results support the hypothesis that the expression of the mouse oxytocin receptor (显示 OXTR ELISA试剂盒) gene is epigenetically regulated by DNA methylation (显示 HELLS ELISA试剂盒) of its promoter.
We conclude that Maged1 (显示 MAGED1 ELISA试剂盒) is required for oxytocin processing or stability. A decrease in mature OT levels in Maged1 (显示 MAGED1 ELISA试剂盒) mutants affects social interactions and possibly other behavioral processes
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1 (显示 IGF1 ELISA试剂盒)/oxytocin system.
loop status modulates dimerization via long-range effects on neurophysin (显示 AVP ELISA试剂盒) conformation involving neighboring Phe22 as a key intermediary
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 (显示 EDN1 ELISA试剂盒) and PGF (显示 PGF ELISA试剂盒)(2alpha) within the corpus luteum.
study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
epigenetic modification of OXT is linked to several overt measures of sociability
Oxytocin prevents cartilage matrix destruction via regulating MMP1 (显示 MMP1 ELISA试剂盒) and MMP13 (显示 MMP13 ELISA试剂盒).
This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor (显示 OXTR ELISA试剂盒).
Oxytocin activates NF-kappaB (显示 NFKB1 ELISA试剂盒)-mediated inflammatory pathways in human gestational tissues in normal parturition.
Report for the first time of a significant genetic association of OXT and AVP (显示 AVP ELISA试剂盒) with schizophrenia
nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38
Patients with poor outcome after aneurysmal subarachnoid hemorrhage have lower AVP (显示 AVP ELISA试剂盒) and OXT levels in cerebrospinal fluid.
dysregulation of OXT, AVP (显示 AVP ELISA试剂盒) and/or testosterone systems exist in mothers of autistic children.
The presence of oxytocin in the mare uterus was determined by radioimmunoassay of tissue extracts and uterine lavage fluid, and by immunohistochemistry.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
, oxytocin-neurophysin 1
, oxytocin, prepro- (neurophysin I)
, oxytocin, prepropeptide
, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
, neurophysin I
, oxytocin-neurophysin I, preproprotein
, oxytocin-neurophysin I