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solution structure of human steroidogenic acute regulatory protein STARD1 studied by small-angle X-ray scattering
Data suggest that expression of STAR (steroidogenic acute regulatory protein) and AKR1B10 (显示 AKR1B10 ELISA试剂盒) (aldo-keto reductase family 1, member B10 (显示 ENPP3 ELISA试剂盒)) is down-regulated in high-grade versus low-grade endometrial tumors; expression of AKR1B10 (显示 AKR1B10 ELISA试剂盒) correlates with body mass index, with up-regulation of expression of AKR1B10 (显示 AKR1B10 ELISA试剂盒) in obese patients with endometrial tumors.
target of the microRNA let-7, which itself is regulated by the long noncoding RNA H19 (显示 NCKAP1 ELISA试剂盒)
Immunostaining of CLOCK and PER2 (显示 PER2 ELISA试剂盒) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (显示 PER2 ELISA试剂盒) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation
activins A, B and AB down-regulate StAR expression and decrease progesterone production in human granulosa cells, likely via an ALK4 (显示 ACVR1B ELISA试剂盒)-mediated SMAD2 (显示 SMAD2 ELISA试剂盒)/SMAD4 (显示 SMAD4 ELISA试剂盒)-dependent pathway.
Mutagenesis confirmed that Arg(312) and Arg(313) are crucial for this mode of regulation, and novel interactions with the START domain
StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON (显示 LONP1 ELISA试剂盒) protease and the inner membrane complexes of the metalloproteases AFG3L2 (显示 AFG3L2 ELISA试剂盒) and AFG3L2 (显示 AFG3L2 ELISA试剂盒):SPG7/paraplegin (显示 SPG7 ELISA试剂盒).
BMP15 (显示 BMP15 ELISA试剂盒) down-regulates StAR expression and decreases progesterone production in human granulosa cells, likely via ALK3 (显示 BMPR1A ELISA试剂盒)-mediated SMAD1 (显示 GARS ELISA试剂盒)/5/8 signaling.
The novel mutation p.Trp147Arg of the steroidogenic acute regulatory protein causes classic lipoid congenital adrenal hyperplasia with adrenal insufficiency and 46,XY disorder of sex development.
Expression of StAR and P45011beta (cytochrome P450 family 11 subfamily B polypeptide 1 (显示 CYP11B1 ELISA试剂盒)) is down-regulated in adrenocortical cells and neurons under oxidative stress by ALADIN (显示 AAAS ELISA试剂盒) (triple A syndrome protein, human) knockdown.
StAR may activate PPARgamma (显示 PPARG ELISA试剂盒) by increasing UFAs, which leads to a protective role in systemic inflammation and insulin (显示 INS ELISA试剂盒) resistance in obese mice.
ChIP results confirmed the binding of NRF1 (显示 NRF1 ELISA试剂盒) to StAR promoter region. In conclusion, decline of NRF1 (显示 NRF1 ELISA试剂盒) expression downregulated the level of StAR, which ultimately resulted in a reduction in testosterone synthesis.
The results demonstrated that ZnT7 (显示 SLC30A7 ELISA试剂盒) gene silencing downregulated the expression of StAR, P450scc (显示 CYP11A1 ELISA试剂盒) and 3beta-HSD (显示 HAL ELISA试剂盒) as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.
cAMP, SIK (显示 SIK1 ELISA试剂盒) and CRTC mediate StAR expression through activation of individual StAR gene loci.
Bisphenol A induces oxidative stress by altering the expression of iNOS (显示 NOS2 ELISA试剂盒), which consequently leads to the down regulation of StAR expression in the testis of male mouse
Results show that HIF1alpha (显示 HIF1A ELISA试剂盒) appears to be a positive regulator of basal and stimulated STAR-expression, which under partial hypoxia is capable of increasing the steroidogenic capacity of granulosa cells.
The result showed significant correlation between changes in GLUT 8 (显示 SLC2A8 ELISA试剂盒) and glucose levels with changes in StAR level in the testis and circulating testosterone level in the mice from birth to senescence
Deletion of the START domain from Arabidopsis Glabra2, a representative HD-Zip transcription factor, results in a complete loss-of-function phenotype. The mammalian START domain from StAR can functionally replace the HD-Zip-derived START domain.
These discoveries highlight the importance of mitochondrial fusion and ERK (显示 EPHB2 ELISA试剂盒) phosphorylation in cholesterol transport by means of directing StAR to the outer mitochondrial membrane.
Results suggest that gonadotropins play a key role in the regulation of StAR, 17beta-HSD3, and P450aromA in zebrafish.
Data indicate that Ser738/742-to-glutamate (显示 GRIN2A ELISA试剂盒) protein kinase D (显示 PRKD1 ELISA试剂盒) mutant increased AngII-induced CREB (显示 CREB1 ELISA试剂盒) protein and activating transcription factor 2 (显示 ATF2 ELISA试剂盒) phosphorylation, and phospho-CREB (显示 CREB1 ELISA试剂盒) binding to the steroidogenic acute regulatory protein promoter.
Data suggest that Escherichia coli infections (here, administration of LPS (显示 IRF6 ELISA试剂盒)) provokes luteolysis in diestrus, non-lactating cows and down-regulation of expression of StAR in corpus luteum but has no effect on luteinization in the following cycle.
The binding of SF-1 (显示 NR5A1 ELISA试剂盒) to the CYP17 (显示 CYP17A1 ELISA试剂盒) and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.
Inhibition of the acetylation of histone H3 (显示 HIST3H3 ELISA试剂盒) associated with the StAR promoter region by BMP-4 (显示 BMP4 ELISA试剂盒) may be one of the inhibitory molecular mechanisms of progesterone synthesis in granulosa cells.
c-Fos/c-Jun (显示 JUN ELISA试剂盒) complex binds to the proximal StAR promoter in glomerulosa cells, thus activating StAR gene expression and acute aldosterone biosynthesis.
We found that adiponectin and insulin (显示 INS ELISA试剂盒) alone regulate the expression of StAR, CYP11A1 (显示 CYP11A1 ELISA试剂盒) and HSD3B1 (显示 HSD3B1 ELISA试剂盒) genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
GATA-4 (显示 GATA4 ELISA试剂盒) and C/EBPbeta (显示 CEBPB ELISA试剂盒) are both required for FSH (显示 BRD2 ELISA试剂盒) +/- IGF-I (显示 IGF1 ELISA试剂盒) stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.
EGF (显示 EGF ELISA试剂盒) repression of FSH (显示 BRD2 ELISA试剂盒)-stimulated StAR transcription in porcine granulosa cells is accompanied by reductions in histone H3 (显示 HIST3H3 ELISA试剂盒) acetylation associated with the StAR gene promoter
The altered ratio of GATA4 (显示 GATA4 ELISA试剂盒) to GATA6 (显示 GATA6 ELISA试剂盒) after ovulation may allow GATA6 (显示 GATA6 ELISA试剂盒) to enhance STAR mRNA accumulation.
Under hypoxia reoxygenation or ischemia and reperfusion, StAR and CYP11A1 protein and gene expression was reduced without apparent relation to TSPO changes.
Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: mc2r (melanocortin 2 receptor (显示 MC2R ELISA试剂盒)); StAR (steroidogenic acute regulatory protein); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
The results showed that MMP-2 (显示 MMP2 ELISA试剂盒), MMP-9 (显示 MMP9 ELISA试剂盒), and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
START domain containing 1
, START domain-containing protein 1
, StAR-related lipid transfer (START) domain containing 1
, cholesterol trafficker
, mitochondrial steroid acute regulatory protein
, steroid acute regulatory protein
, steroidogenic acute regulator
, steroidogenic acute regulatory protein, mitochondrial
, luteinizing hormone-induced protein
, lipid transporter
, steroidogenic acute regulatory protein
, mitochondrial steroidogenic acute regulatory protein