Use your antibodies-online credentials, if available.
Select your species
Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (显示 PRKAA1 ELISA试剂盒)/p38 MAPK (显示 MAPK14 ELISA试剂盒)-ERK3 (显示 MAPK4 ELISA试剂盒)/mTORC1 pathways. ERK3 (显示 MAPK4 ELISA试剂盒) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (显示 TDP2 ELISA试剂盒) activity and discovered a new role of ERK3 (显示 MAPK4 ELISA试剂盒) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (显示 TOP2A ELISA试剂盒) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (显示 MAPK4 ELISA试剂盒) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (显示 NCOA3 ELISA试剂盒)/SP-1 (显示 PSG1 ELISA试剂盒)-mediated VEGFR2 (显示 KDR ELISA试剂盒) expression.
These findings further expand distinct roles of cyclin D3 (显示 CCND3 ELISA试剂盒) and suggest the potential activity of ERK3 (显示 MAPK4 ELISA试剂盒) in cell proliferation.
Cdc14A (显示 CDC14A ELISA试剂盒) forms a stable complex with atypical mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒) Erk3 (显示 MAPK4 ELISA试剂盒) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (显示 MAPK4 ELISA试剂盒) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (显示 MAPK1 ELISA试剂盒) signaling.
A previously unknown role for ERK3 (显示 MAPK4 ELISA试剂盒) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (显示 NCOA3 ELISA试剂盒) and regulating SRC-3 (显示 NCOA3 ELISA试剂盒) proinvasive activity by site-specific phosphorylation.
ERK3 (显示 MAPK4 ELISA试剂盒) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (显示 CDKN1A ELISA试剂盒) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (显示 RYK ELISA试剂盒) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (显示 RYK ELISA试剂盒)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (显示 MAPKAPK5 ELISA试剂盒) or PRAK (显示 MAPKAPK5 ELISA试剂盒)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (显示 MAPKAPK5 ELISA试剂盒)).
p38gamma (显示 MAPK12 ELISA试剂盒) MAP kinase (显示 MAPK1 ELISA试剂盒) (SAPK3/p38gamma (显示 MAPK12 ELISA试剂盒)) was shown to catalyse phosphorylation of SAP97 (显示 DLG1 ELISA试剂盒).
Results show that Cdo (显示 CDO1 ELISA试剂盒) is important for full Abl kinase activity, and Abl (显示 ABL1 ELISA试剂盒) is necessary for full activation of p38 MAPK (显示 MAPK14 ELISA试剂盒), during myogenic differentiation.
results indicated that AIK1-MKK5 (显示 MAP2K5 ELISA试剂盒)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (显示 MAPK1 ELISA试剂盒) cascade.
MPK6 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3 (显示 MAPK3 ELISA试剂盒)/MPK6 cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
MPK6-mediated regulation of MYB15 plays an important role in cold stress signaling in Arabidopsis.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 (显示 MAPK3 ELISA试剂盒) and MPK6 can both interact with SPOROCYTELESS/NOZZLE (SPL (显示 SGPL1 ELISA试剂盒)) in vitro and in vivo and can phosphorylate the SPL (显示 SGPL1 ELISA试剂盒) protein in vitro.
AIK1-MKK5 (显示 MAP2K5 ELISA试剂盒)-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
A novel mechanism for PIN1 phosphorylation involving MKK7 (显示 MAP2K7 ELISA试剂盒) and MPK6 in shoot branching regulation in Arabidopsis.
MKK4 (显示 MAP2K4 ELISA试剂盒), MKK5 (显示 MAP2K5 ELISA试剂盒), MKK7 (显示 MAP2K7 ELISA试剂盒), and MKK9, are responsible for the activation of MPK3 (显示 MAPK3 ELISA试剂盒) and MPK6 by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 ELISA试剂盒) signaling through MKK4 (显示 MAP2K4 ELISA试剂盒)/5/7/9-MPK3 (显示 MAPK3 ELISA试剂盒)/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 (显示 MAPK3 ELISA试剂盒) and MPK6, are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6