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AtMKK6 (显示 MAP2K6 ELISA试剂盒)-AtMPK13 (显示 MAPK1/3 ELISA试剂盒) module positively regulates lateral root formation.[AtMPK13 (显示 MAPK1/3 ELISA试剂盒)]
The p38delta (显示 MAPK1/3 ELISA试剂盒) mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒) was identified as a novel regulator of NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation.
p38delta (显示 MAPK1/3 ELISA试剂盒) expression was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. No significant association was found for p38delta (显示 MAPK1/3 ELISA试剂盒) between its expression and other clinicopathological parameters. In Eca109 cells, p38delta (显示 MAPK1/3 ELISA试剂盒) can promote the cell growth and motility. p38delta (显示 MAPK1/3 ELISA试剂盒) overexpression promotes tumorigenesis in nude mice when p38delta (显示 MAPK1/3 ELISA试剂盒) was stably over-expressed and p38ga...
MAPK13 gene knockdown using siRNA reduced the aldehyde dehydrogenase high cell population and abrogated the tumor-initiating ability.
p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD (显示 TSC2 ELISA试剂盒) therapy
MAPK13 (显示 MAPK1/3 ELISA试剂盒) undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14 (显示 MAPK14 ELISA试剂盒).
PKCdelta (显示 PKCd ELISA试剂盒) activates a MEKK1 (显示 MAP3K1 ELISA试剂盒)/MEK3 (显示 MAP2K3 ELISA试剂盒)/p38delta (显示 MAPK1/3 ELISA试剂盒) MAPK (显示 MAPK1 ELISA试剂盒) cascade to increase p53 (显示 TP53 ELISA试剂盒) levels and p53 (显示 TP53 ELISA试剂盒) drives p21(Cip1 (显示 CDKN1A ELISA试剂盒)) gene expression.
esophageal squamous cell carcinoma cell lines which are p38delta (显示 MAPK1/3 ELISA试剂盒)-negative grew more quickly than cell lines which express endogenous p38delta (显示 MAPK1/3 ELISA试剂盒).
DNA methylation (显示 HELLS ELISA试剂盒) alterations are widespread in melanoma; epigenetic silencing of MAPK13 (显示 MAPK1/3 ELISA试剂盒) contributes to melanoma progression
Data indicate that p38delta mediates oncogene-induced senescence through a p53- and p16(INK4A)-independent mechanism.
GSK3alpha, GSK3beta (显示 GSK3b ELISA试剂盒), and MAPK13 (显示 MAPK1/3 ELISA试剂盒) were found to be the most active tau kinases, phosphorylating tau at all four epitopes.
Results reveal that p38delta (显示 MAPK1/3 ELISA试剂盒) contributes both cell-autonomous and paracrine effects during the course of skin tumor formation.
p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) control heart growth by modulating mTOR (显示 FRAP1 ELISA试剂盒) pathway through DEPTOR (显示 DEPTOR ELISA试剂盒) phosphorylation and subsequent degradation.
Together, our results establish that p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma (显示 MAPK12 ELISA试剂盒) and p38kappa as potential targets for cancer therapy.
p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) are crucial regulators of inflammatory joint destruction in collagen-induced arthritis.
p27 (显示 CDKN1B ELISA试剂盒) inhibition of COX-2 (显示 COX2 ELISA试剂盒) expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB (显示 CREB1 ELISA试剂盒)) phosphorylation mediated by p38beta (显示 MAPK11 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒).
Aberrant p38delta (显示 MAPK1/3 ELISA试剂盒)-PKD1 (显示 PKD1 ELISA试剂盒) signaling in neutrophils may underlie development of acute lung injury and life-threatening acute respiratory distress syndrome.
p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) kinases regulate the Toll-like receptor 4 (TLR4 (显示 TLR4 ELISA试剂盒))-induced cytokine production by controlling ERK1/2 (显示 MAPK1/3 ELISA试剂盒) protein kinase (显示 CDK7 ELISA试剂盒) pathway activation
results indicate that p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) have a role in the suppression of tumor development
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene.
MAP kinase 13
, MAPK 13
, MAP kinase p38 delta
, mitogen-activated protein kinase p38 delta
, stress-activated protein kinase 4
, SAPK/Erk/kinase 4
, mitogen activated protein kinase 13
, p38 delta MAP kinase
, mitogen-activated protein kinase 13