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Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.
Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (显示 STAT3 ELISA试剂盒) augments breast cancer cell EMT (显示 ITK ELISA试剂盒), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (显示 STAT3 ELISA试剂盒) and MEK5/Erk5 (显示 MAPK7 ELISA试剂盒) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.
Our findings confirm an association between the BTBD9 (显示 BTBD9 ELISA试剂盒), MEIS1 (显示 MEIS1 ELISA试剂盒), and MAP2K5/SKOR1 (显示 SKOR1 ELISA试剂盒) SNPs and periodic limb movements of sleep in an elderly cohort.
Specifically, CKS1B (显示 CKS1B ELISA试剂盒) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (显示 PACSIN1 ELISA试剂盒), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
High MEK5 expression is associated with colorectal cancer.
SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (显示 BTBD9 ELISA试剂盒), TOX3 (显示 TOX3 ELISA试剂盒)/BC034767, MEIS1 (显示 MEIS1 ELISA试剂盒), MAP2K5/SKOR1 (显示 SKOR1 ELISA试剂盒), and PTPRD (显示 PTPRD ELISA试剂盒)
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2 (显示 MAP3K2 ELISA试剂盒)/3-MEK5-ERK5 (显示 MAPK7 ELISA试剂盒) signaling.
MiR (显示 MLXIP ELISA试剂盒)-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits
MEK5/ERK5 (显示 MAPK7 ELISA试剂盒) signaling suppresses estrogen receptor (显示 ESR1 ELISA试剂盒) expression and promotes hormone-independent tumorigenesis.
These results suggest that YAP (显示 YAP1 ELISA试剂盒) promotes muscle differentiation by activating the Abl (显示 ABL1 ELISA试剂盒)/Src (显示 SRC ELISA试剂盒)/MEKK3 (显示 MAP3K3 ELISA试剂盒)/MEK5/ERK5 (显示 MAPK7 ELISA试剂盒) kinase cascade.
MEK5 overexpression inhibits differentiation of osteoblasts.
the MEK5-ERK5 (显示 MAPK7 ELISA试剂盒) MAP kinase (显示 MAPK1 ELISA试剂盒) signaling pathway has a critical role in BAFF (显示 TNFSF13B ELISA试剂盒)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
The MEK5/ERK5 (显示 MAPK7 ELISA试剂盒) pathway also mediates FSS-induced Runx-2 (显示 RUNX2 ELISA试剂盒) expression in osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
PB1 domain mediates the association of MEKK2 (显示 MAP3K2 ELISA试剂盒) and MEKK3 (显示 MAP3K3 ELISA试剂盒) with MEK5 and that the respective PB1 domains of these kinases are critical for regulation of the ERK5 (显示 MAPK7 ELISA试剂盒) pathway.
MEK5 is an activator of ERK5 (显示 MAPK7 ELISA试剂盒) and an essential regulator of cell survival that is required for normal embryonic development
the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (显示 MAPK7 ELISA试剂盒) signaling pathway
MEK5 and big MAP kinase 1 (BMK1 (显示 MAPK7 ELISA试剂盒)) function downstream of MEKK3 (显示 MAP3K3 ELISA试剂盒) in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 (显示 PPP3R1 ELISA试剂盒)
A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (显示 MAPK7 ELISA试剂盒) kinase and map2k7 (显示 MAP2K7 ELISA试剂盒) signaling.
AIK1-MKK5-MPK6 (显示 MAPK6 ELISA试剂盒) cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
MKK4 (显示 MAP2K4 ELISA试剂盒), MKK5, MKK7 (显示 MAP2K7 ELISA试剂盒), and MKK9, are responsible for the activation of MPK3 (显示 MAPK3 ELISA试剂盒) and MPK6 (显示 MAPK6 ELISA试剂盒) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 ELISA试剂盒) signaling through MKK4 (显示 MAP2K4 ELISA试剂盒)/5/7/9-MPK3 (显示 MAPK3 ELISA试剂盒)/6 cascades.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (显示 MAPK6 ELISA试剂盒), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
our data indicate that EDR1 (显示 PHC1 ELISA试剂盒) physically associates with MKK4 (显示 MAP2K4 ELISA试剂盒)/MKK5 and negatively regulates the MAPK (显示 MAPK1 ELISA试剂盒) cascade to fine-tune plant innate immunity.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (显示 TGFB1 ELISA试剂盒) as well as the activation of MKK5 activity were completely arrested.
Results suggest that the YDA-MKK4 (显示 MAP2K4 ELISA试剂盒)/MKK5-MPK3 (显示 MAPK3 ELISA试剂盒)/MPK6 (显示 MAPK6 ELISA试剂盒) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK5 functions both in ozone-induced activation of MPK3 (显示 MAPK3 ELISA试剂盒) and MPK6 (显示 MAPK6 ELISA试剂盒) and in integrating reactive oxygen species homeostasis during ozone stress.
MKK5 is a key regulator of stomatal development and patterning.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5