anti-犬 Cortactin 抗体 for Immunohistochemistry (Formalin-fixed Sections)

Recommended Cortactin Antibody (supplied by: Log in to see )

抗原
Cortactin (CTTN) 抗体
  • Cttn
  • CTTN
  • cttn
  • ems1
  • CG3637
  • Dmel\CG3637
  • cortactin
  • 1110020L01Rik
  • Ems1
  • CTTN1
  • P85.25
  • EMS1
  • Cttnb
  • cortactin
  • src substrate cortactin
  • Src substrate cortactin
  • CG3637 gene product from transcript CG3637-RD
  • CTTN
  • Cttn
  • cttn
  • CpipJ_CPIJ006351
  • Bm1_57220
  • LOC100533277
  • Cortactin
适用
犬, 人
202
126
76
8
7
6
4
3
3
3
3
1
1
1
1
1
1
宿主
小鼠
182
31
19
克隆类型
单克隆
标记
This Cortactin antibody is un-conjugated
4
4
4
4
4
4
应用范围
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
208
102
90
40
22
17
13
5
3
3
2
1
1
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

产品编号 ABIN967710
产品在该地区无法提供。
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN967709 IHC (f) IF IP WB Mouse IgG1 Log in to see 30-Cortactin 5

General

抗原 Cortactin (CTTN) 抗体
适用 犬, 人
(202), (126), (76), (8), (7), (6), (4), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
宿主 小鼠
(182), (31), (19)
克隆类型 (克隆位点)
单克隆   ( )
标记 This Cortactin antibody is un-conjugated
(4), (4), (4), (4), (4), (4)
应用范围 Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(208), (102), (90), (40), (22), (17), (13), (5), (3), (3), (2), (1), (1), (1)
Pubmed 6个引用可参考
Supplier Log in to see

Cortactin抗体详情

Cortactin目标详情 使用细节 贮存及处理 References for anti-Cortactin antibody (ABIN967710) 图像
交叉反应 人, 犬
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
免疫原 Chicken Cortactin
克隆位点 30-Cortactin
亚型 IgG1

Cortactin目标详情

Cortactin抗体详情 使用细节 贮存及处理 References for anti-Cortactin antibody (ABIN967710) 图像 回页首
抗原
别名 Cortactin (CTTN Antibody 摘要)
背景 Cortactin is a protein which is represented by two structurally related isoforms of 80 kDa and 85 kDa. Sequence analysis of this protein reveals the presence of a carboxy-terminal SH3 domain, as well as six internal tandem repeats of a 37 amino acid sequence. It is able to bind to F-actin via this N-terminal repeat region, and colocalizes with actin in the cell. Cortactin was originally described as a protein that is tyrosine-phosphorylated in cells transformed by the src oncogene, in which it localizes to rosettes or podosomes. It has since been shown that other stimuli, such as bacterial invasion, treatment with growth factors, and integrin-mediated cell adhesion, are also capable of inducing phosphorylation of cortactin. Some additional evidence indicates that cortactin may actually be a substrate of syk, with src acting as an upstream signaling molecule. This antibody is routinely tested by western blot analysis.
分子量 85/80 kDa
研究领域 Cancer, Cell Cycle, Cytoskeleton, Microfilaments
途径 MAPK Pathway

使用细节

Cortactin抗体详情 Cortactin目标详情 贮存及处理 References for anti-Cortactin antibody (ABIN967710) 图像 回页首
说明

Related Products: ABIN968533, ABIN967389

限制 仅限研究用

贮存及处理

Cortactin抗体详情 Cortactin目标详情 使用细节 References for anti-Cortactin antibody (ABIN967710) 图像 回页首
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store undiluted at -20°C.

References for anti-Cortactin antibody (ABIN967710)

Cortactin抗体详情 Cortactin目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Cantarelli, Takahashi, Yanagihara, Akeda, Imura, Kodama, Kono, Sato, Iida, Honda: "Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infection." in: Infection and immunity, Vol. 70, Issue 4, pp. 2206-9, 2002

Lavoie, Champagne, Gingras, Robert: "Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases." in: The Journal of cell biology, Vol. 150, Issue 5, pp. 1037-56, 2000

Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, 1998

Dehio, Prévost, Sansonetti: "Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway." in: The EMBO journal, Vol. 14, Issue 11, pp. 2471-82, 1995

Wu, Parsons: "Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex." in: The Journal of cell biology, Vol. 120, Issue 6, pp. 1417-26, 1993

Wu, Reynolds, Kanner, Vines, Parsons: "Identification and characterization of a novel cytoskeleton-associated pp60src substrate." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5113-24, 1991

图像

Cortactin抗体详情 Cortactin目标详情 使用细节 贮存及处理 References for anti-Cortactin antibody (ABIN967710) 回页首
厂商提供的图像
Western Blotting (WB) image for anti-Cortactin (CTTN) antibody (ABIN967710) Western blot analysis of Cortactin on a A431 lysate. Lane 1: 1:1000, lane 2: 1:2000, ...
Immunofluorescence (IF) image for anti-Cortactin (CTTN) antibody (ABIN967710) Immunofluoresence staining of NIH-3T3 cells.
 image for anti-Cortactin (CTTN) antibody (ABIN967710) anti-Cortactin (CTTN) antibody (Image 3)
Western Blotting (WB) image for anti-Cortactin (CTTN) antibody (ABIN967710) anti-Cortactin (CTTN) antibody (Image 4)