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anti-PPP1R12A (PPP1R12A) 抗体产品概述

Full name:
anti-Myosin Phosphatase, Target Subunit 1 抗体 (PPP1R12A)
在www.antibodies-online.cn可供96 Myosin Phosphatase, Target Subunit 1 (PPP1R12A) 抗体的15不同的供货商。 再加上,我们可以发PPP1R12A 试剂盒 (6)PPP1R12A 蛋白 (4)和数多这个蛋白质的别的产品。 总共115 PPP1R12A产品已列进来了。
别名:
1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, M110, M130, MBS, MBSP, MYPT1
列出全部抗体 基因 基因ID UniProt
PPP1R12A 17931 Q9DBR7
PPP1R12A 4659 O14974
PPP1R12A 116670 Q10728

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  1. Human Monoclonal PPP1R12A Primary Antibody for WB - ABIN968767 : Chen, Chen, Alessi, Campbell, Shanahan, Cohen, Cohen: Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. in FEBS letters 1995 (PubMed)
    Show all 3 references for ABIN968767

更多抗PPP1R12A的相互作用对抗体

Mouse (Murine) Myosin Phosphatase, Target Subunit 1 (PPP1R12A) interaction partners

  1. Mypt1 E24 splice variants tune arterial reactivity and could be worthy targets for lowering vascular resistance in disease states.

  2. revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice

  3. phosphorylation of MYPT1 T694, but not T852, mediates force maintenance in bladder smooth muscle.

  4. Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle

  5. Maturation of mesenteric artery smooth muscle involves TRA2beta (显示 TRA2B 抗体) mediated Mypt1 exon 24 splicing.

  6. The role of MYPT1 in vascular smooth muscle was investigated in adult MYPT1 smooth muscle specific knock-out mice. MYPT1 deletion enhanced phosphorylation of myosin regulatory light chain and contractile force in isolated mesenteric arteries.

  7. MYPT1 is not essential for smooth muscle function in mice but regulates the Ca(2 (显示 CA2 抗体)+) sensitivity of force development and contributes to intestinal phasic contractile phenotype.

  8. Tra2beta (显示 TRA2B 抗体), by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation.

  9. Organ-specific mechanisms involving MYPT1, M-RIP (显示 MPRIP 抗体), and CPI-17 (显示 PPP1R14A 抗体) are critical to regulating basal LC20 (显示 MYL9 抗体) phosphorylation in gastrointestinal smooth muscles.

  10. Findings define a new conserved pathway in which sexual development and pregnancy mediate smooth and striated (显示 NSDHL 抗体) muscle adaptations through SMTNL1 and MYPT1.

Human Myosin Phosphatase, Target Subunit 1 (PPP1R12A) interaction partners

  1. Study revealed the presence of two MYPT1 isoforms, full length and variant 2 in human intestinal (Caco-2) epithelial cells and isolated intestinal epithelial cells from mice.

  2. These results indicate that PPP1R12A indeed plays a role in skeletal muscle insulin (显示 INS 抗体) signaling

  3. the relative expression of LZ+/LZ (显示 LYZ 抗体)- MYPT1 isoforms, in part, defines the vascular response to NO and NO based vasodilators, and therefore, plays a role in the regulation of vascular tone in both health and disease

  4. Expression of NUAK1 (显示 NUAK1 抗体) is controlled by cyclin-dependent kinase (显示 CDK1 抗体), PLK1 (显示 PLK1 抗体), and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase (显示 MUL1 抗体) complex.

  5. distinct roles of two inhibitory phosphorylation sites of MYPT1

  6. in apoptotic cells, the myosin-binding domain of myosin phosphatase targeting subunit 1 is cleaved by caspase-3, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding

  7. results suggested that during atherosclerosis progression oxidative stress mediates the downregulation of MYPT1, which may inhibit smooth muscle cell migration and contribute to the aberrant contractility

  8. Calcineurin (显示 PPP3CA 抗体) may modulate the phosphorylation level of MLC20 (显示 MYL12B 抗体) by influencing the phosphorylation state of MYPT1 to regulate endothelial barrier function.

  9. Mypt1 colocalizes outside the nucleus with Nkx2.5 in a manner dependent on Wnt signaling and Rho-associated protein kinase.

  10. These findings provide evidence for the involvement of a particular PP1 (显示 PPA1 抗体) complex, PPP1R12A/PP1cdelta, in insulin (显示 INS 抗体) signaling.

PPP1R12A 抗原简介

Antigen Summary

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PPP1R12A

  • protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) 抗体
  • protein phosphatase 1, regulatory subunit 12A (PPP1R12A) 抗体
  • protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) 抗体
  • 1200015F06Rik 抗体
  • 5730577I22Rik 抗体
  • AA792106 抗体
  • AV099298 抗体
  • D10Ertd625e 抗体
  • M110 抗体
  • M130 抗体
  • MBS 抗体
  • MBSP 抗体
  • MYPT1 抗体

Protein level used designations for PPP1R12A

myosin phosphatase target subunit 1 , myosin phosphatase, target subunit 1 , myosin phosphatase-targeting subunit 1 , protein phosphatase 1 regulatory subunit 12A , myosin binding subunit , protein phosphatase 1, regulatory (inhibitor) subunit 12A , protein phosphatase myosin-binding subunit , PP-1M , protein phosphatase subunit 1M , serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110 , smooth muscle myosin phosphatase myosin-binding subunit , 130 kDa myosin-binding subunit of smooth muscle myosin phophatase , 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase , 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133) , PP1M subunit M110

GENE ID SPECIES
17931 Mus musculus
4659 Homo sapiens
116670 Rattus norvegicus
396020 Gallus gallus
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