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Rif1 (显示 INSL6 ELISA试剂盒) can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 (显示 CHEK1 ELISA试剂盒) activity.
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (显示 EIF2S1 ELISA试剂盒) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (显示 ATF4 ELISA试剂盒) expression. (eIF2a (显示 EIF2S1 ELISA试剂盒) = eukaryotic initiation factor-2alpha (显示 EIF2S1 ELISA试剂盒); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (显示 ATF4 ELISA试剂盒) = activating transcription factor 4 (显示 ATF4 ELISA试剂盒))
Protein phosphatase 1 (显示 PPP1CB ELISA试剂盒) (PP1 (显示 PPA1 ELISA试剂盒)) forms stable complexes with PP1 (显示 PPA1 ELISA试剂盒)-interacting proteins (PIPs (显示 GPRASP1 ELISA试剂盒)) that guide the phosphatase throughout its life cycle and control its fate and function.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
this study shows a pivotal role for PP1 (显示 PPA1 ELISA试剂盒) in impeding IRF7 (显示 IRF7 ELISA试剂盒)-mediated IFN-alpha (显示 IFNA ELISA试剂盒) production in host immune responses
The data support a model where Cdc7 (显示 CDC7 ELISA试剂盒) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (显示 CDC7 ELISA试剂盒) and PP1a/Cdk1 (显示 CDK1 ELISA试剂盒) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
These results indicate that PP1 (显示 PPA1 ELISA试剂盒) is recruited to the extracellular calcium-dependent E-cadherin (显示 CDH1 ELISA试剂盒)-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC (显示 HSPG2 ELISA试剂盒)-g1 activation leading to keratinocyte differentiation.
Data suggest that targeting protein phosphatase 1 catalytic subunit (显示 PPP1CB ELISA试剂盒) (PP1alpha) or the androgen receptor AR (显示 AR ELISA试剂盒)-PP1alpha interaction may be effective in castration-resistant prostate cancer (CRPC).
Both PP-1 and PP-2A are directly involved in regulating eye development, and are aberrantly expressed in cataract and glaucoma patients. (Review)
Data suggest that activation of TAZ (tafazzin (显示 TAZ ELISA试剂盒)) inhibits adipogenesis in mesenchymal stem cells; interaction of TAZ (显示 TAZ ELISA试剂盒) and protein phosphatases (PP1A, PP2A (显示 PPP2R4 ELISA试剂盒)) up-regulates dephosphorylation and transport of TAZ (显示 TAZ ELISA试剂盒) to cell nucleus.
Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (显示 GNB1 ELISA试剂盒) interact in quiescent platelets; then, Ppp1ca and Plcb3 (显示 PLCB3 ELISA试剂盒) interact during platelet aggregation; thus, Gnb1 (显示 GNB1 ELISA试剂盒) enlists Ppp1ca to modulate G protein-coupled receptor (显示 GPR34 ELISA试剂盒) signaling. (Ppp1ca = protein phosphatase 1 (显示 PPP1CB ELISA试剂盒), catalytic subunit alpha; Gnb1 (显示 GNB1 ELISA试剂盒) = guanine nucleotide-binding protein (显示 TRIM23 ELISA试剂盒), subunit beta-1; Plcb3 (显示 PLCB3 ELISA试剂盒) = phospholipase C (显示 PLC ELISA试剂盒), subunit beta-3)
Ang IV functions via regulating the activity of PP1
Cell surface expression of the major amyloid-beta peptide (Abeta (显示 APP ELISA试剂盒))-degrading enzyme, neprilysin (显示 MME ELISA试剂盒), depends on phosphorylation by mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒)/extracellular signal-regulated kinase kinase (MEK (显示 MDK ELISA试剂盒)) and dephosphorylation by protein phosphatase 1a (显示 PPM1A ELISA试剂盒).
analysis of selective regulation of NR2B (显示 GRIN2B ELISA试剂盒) by protein phosphatase-1 (显示 PPP1CB ELISA试剂盒) for the control of the NMDA receptor in neuroprotection
alteration of lipid rafts is an early event in the apoptotic cascade indirectly induced by interleukin-4 (显示 IL4 ELISA试剂盒) deprivation via PP1alpha activation, dephosphorylation of cytoplasmic Bad, and caspase (显示 CASP3 ELISA试剂盒) activation
Data show that Nck (显示 NCK1 ELISA试剂盒) (isoforms 1 and 2) as a component of the CReP (显示 PPP1R15B ELISA试剂盒)/PP1c holophosphatase complex contributes to maintain eIF2alpha (显示 EIF2A ELISA试剂盒) in a hypophosphorylated state, and modulates translation and eIF2alpha (显示 EIF2A ELISA试剂盒) signaling in response to ER stress.
Our system may be useful for the elucidation of the mechanism of morphological maturation of neuronal cells such as dorsal root ganglion neurons that express SREC-I (显示 SCARF1 ELISA试剂盒) during early development.
Ppp1ca was identified in the study.
overexpression of two out of five PPP1CA alternative spliced variants reduced tumor cell growth and the downregulation of the protein to hemizygosity increased the anchorage-independent growth
Results demonstrate myofilament regulation by protein phosphatase type 1 alpha and CapZ (显示 CAPZA1 ELISA试剂盒), and support the concept that cardiac Z-discs are vital components in intracellular signalling.
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 1, catalytic subunit, alpha isoform
, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
, serine/threonine-protein phosphatase PP1-alpha catalytic subunit
, Protein phosphatase type 1 alpha, catalytic subunit
, protein phosphatase-1d
, protein phosphatase 1, catalytic subunit, alpha
, protein phosphatase 1A
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, protein phosphatase 2C isoform alpha
, PP1 alpha
, protein phosphatase 1 alpha