Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) ELISA试剂盒产品概述

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Protein Phosphatase 1, Catalytic Subunit, alpha Isoform ELISA试剂盒 (PPP1CA)
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2310003C21Rik, 2900017D14Rik, AI427932, AU017636, dism2, MMPa-2, MPPa-1, PP-1A, PP1A, PP1alpha, PP2C-ALPHA, PP2CA, PP2Calpha, PPP1A, Ppp1c, wu:fc04c08, wu:fc09b07, wu:fc30g11, wu:fe05h08, zgc:85729

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) ELISA试剂盒 by Reactivity

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Mouse (Murine) Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (显示 GNB1 ELISA试剂盒) interact in quiescent platelets; then, Ppp1ca and Plcb3 (显示 PLCB3 ELISA试剂盒) interact during platelet aggregation; thus, Gnb1 (显示 GNB1 ELISA试剂盒) enlists Ppp1ca to modulate G protein-coupled receptor (显示 GPR34 ELISA试剂盒) signaling. (Ppp1ca = protein phosphatase 1 (显示 PPP1CB ELISA试剂盒), catalytic subunit alpha; Gnb1 (显示 GNB1 ELISA试剂盒) = guanine nucleotide-binding protein (显示 TRIM23 ELISA试剂盒), subunit beta-1; Plcb3 (显示 PLCB3 ELISA试剂盒) = phospholipase C (显示 PLC ELISA试剂盒), subunit beta-3)

  2. findings demonstrate a novel regulatory circuit in which STING and TBK1 (显示 TBK1 ELISA试剂盒) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (显示 PPM1A ELISA试剂盒) dephosphorylates STING and TBK1 (显示 TBK1 ELISA试剂盒)

  3. the studies presented here position PPM1A (显示 PPM1A ELISA试剂盒) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  4. Ang (显示 ANG ELISA试剂盒) IV functions via regulating the activity of PP1 (显示 PPP1CC ELISA试剂盒)

  5. a nuclear envelope-localized mechanism of inactivating TGF-beta (显示 TGFB1 ELISA试剂盒) signaling in which MAN1 (显示 LEMD3 ELISA试剂盒) competes with transcription factors for binding to Smad2 (显示 SMAD2 ELISA试剂盒) and Smad3 (显示 SMAD3 ELISA试剂盒) and facilitates their dephosphorylation by PPM1A (显示 PPM1A ELISA试剂盒).

  6. Although a non-myristoylated mutation (G2A) of PPM1A (显示 PPM1A ELISA试剂盒) and PPM1B (显示 PPM1B ELISA试剂盒) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (显示 GRK4 ELISA试剂盒).

  7. we found that PPM1A (显示 PPM1A ELISA试剂盒) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (显示 PPM1A ELISA试剂盒) protein

  8. Cell surface expression of the major amyloid-beta peptide (Abeta (显示 APP ELISA试剂盒))-degrading enzyme, neprilysin (显示 MME ELISA试剂盒), depends on phosphorylation by mitogen-activated protein kinase (显示 MAPK1 ELISA试剂盒)/extracellular signal-regulated kinase kinase (MEK (显示 MDK ELISA试剂盒)) and dephosphorylation by protein phosphatase 1a (显示 PPM1A ELISA试剂盒).

  9. analysis of selective regulation of NR2B (显示 GRIN2B ELISA试剂盒) by protein phosphatase-1 (显示 PPP1CB ELISA试剂盒) for the control of the NMDA receptor in neuroprotection

  10. Protein phosphatase PPM1A (显示 PPM1A ELISA试剂盒) regulates the nuclear export of Smad2 (显示 SMAD2 ELISA试剂盒)/3 through targeting nuclear exporter RanBP3 (显示 RANBP3 ELISA试剂盒).

Human Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. establish PPM1A (显示 PPM1A ELISA试剂盒) as a novel repressor of the SMAD3 (显示 SMAD3 ELISA试剂盒) pathway in renal fibrosis

  2. Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (显示 EIF2S1 ELISA试剂盒) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (显示 ATF4 ELISA试剂盒) expression. (eIF2a (显示 EIF2S1 ELISA试剂盒) = eukaryotic initiation factor-2alpha (显示 EIF2S1 ELISA试剂盒); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (显示 ATF4 ELISA试剂盒) = activating transcription factor 4 (显示 ATF4 ELISA试剂盒))

  3. Report a tumor-suppressive function of PPM1A (显示 PPM1A ELISA试剂盒) and an independent relationship to Smad4 (显示 SMAD4 ELISA试剂盒) in pancreatic ductal adenocarcinoma.

  4. Protein phosphatase 1 (显示 PPP1CB ELISA试剂盒) (PP1 (显示 PPA1 ELISA试剂盒)) forms stable complexes with PP1 (显示 PPA1 ELISA试剂盒)-interacting proteins (PIPs (显示 GPRASP1 ELISA试剂盒)) that guide the phosphatase throughout its life cycle and control its fate and function.

  5. The authors found that RNA recognition motif 1 (RRM1 (显示 RRM1 ELISA试剂盒)) in SRSF1 (显示 SRSF1 ELISA试剂盒) binds PP1 (显示 PPA1 ELISA试剂盒) and represses its catalytic function through an allosteric mechanism.

  6. this study shows a pivotal role for PP1 (显示 PPA1 ELISA试剂盒) in impeding IRF7 (显示 IRF7 ELISA试剂盒)-mediated IFN-alpha (显示 IFNA ELISA试剂盒) production in host immune responses

  7. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha (显示 PPM1A ELISA试剂盒) between the active and inactive states

  8. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A (显示 PPM1A ELISA试剂盒); P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.

  9. The data support a model where Cdc7 (显示 CDC7 ELISA试剂盒) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (显示 CDC7 ELISA试剂盒) and PP1a/Cdk1 (显示 CDK1 ELISA试剂盒) to the regulation of once-per-cell cycle DNA replication in mammalian cells.

  10. These results indicate that PP1 (显示 PPA1 ELISA试剂盒) is recruited to the extracellular calcium-dependent E-cadherin (显示 CDH1 ELISA试剂盒)-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC (显示 HSPG2 ELISA试剂盒)-g1 activation leading to keratinocyte differentiation.

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA)

  • protein phosphatase 1, catalytic subunit, alpha isozyme (ppp1ca) Elisa Kit
  • protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA) Elisa Kit
  • protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca) Elisa Kit
  • protein phosphatase 1, catalytic subunit, alpha isoform a (ppp1caa) Elisa Kit
  • protein phosphatase 1, catalytic subunit, alpha isozyme (Ppp1ca) Elisa Kit
  • protein phosphatase 1, catalytic subunit, beta isozyme (Ppp1cb) Elisa Kit
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a) Elisa Kit
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A) Elisa Kit
  • 2310003C21Rik Elisa Kit
  • 2900017D14Rik Elisa Kit
  • AI427932 Elisa Kit
  • AU017636 Elisa Kit
  • dism2 Elisa Kit
  • MMPa-2 Elisa Kit
  • MPPa-1 Elisa Kit
  • PP-1A Elisa Kit
  • PP1A Elisa Kit
  • PP1alpha Elisa Kit
  • PP2C-ALPHA Elisa Kit
  • PP2CA Elisa Kit
  • PP2Calpha Elisa Kit
  • PPP1A Elisa Kit
  • Ppp1c Elisa Kit
  • wu:fc04c08 Elisa Kit
  • wu:fc09b07 Elisa Kit
  • wu:fc30g11 Elisa Kit
  • wu:fe05h08 Elisa Kit
  • zgc:85729 Elisa Kit

Protein level used designations for PPP1CA

Protein phosphatase type 1 alpha, catalytic subunit , protein phosphatase 1, catalytic subunit, alpha isoform , PP-1A , serine/threonine-protein phosphatase PP1-alpha catalytic subunit , ppp1ca , protein phosphatase 1, catalytic subunit, alpha , serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit , protein phosphatase-1d , PP-1B , protein phosphatase 1, catalytic subunit, beta isoform , protein phosphatase-1a , serine/threonine-protein phosphatase PP1-beta catalytic subunit , Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , protein phosphatase 2C alpha

GENE ID SPECIES
379914 Xenopus laevis
745709 Pan troglodytes
100059233 Equus caballus
100145598 Xenopus (Silurana) tropicalis
19045 Mus musculus
407980 Danio rerio
5499 Homo sapiens
24668 Rattus norvegicus
516175 Bos taurus
403609 Canis lupus familiaris
100009298 Oryctolagus cuniculus
25594 Rattus norvegicus
19042 Mus musculus
5494 Homo sapiens
281994 Bos taurus
100009431 Oryctolagus cuniculus
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