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Data support a model in which NF45 (显示 ILF2 ELISA试剂盒), NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues.
Reduction in the expression of YBX1 (显示 YBX1 ELISA试剂盒) and ILF3 controls the expression of pluripotency-related genes in ESCs (显示 NR2E3 ELISA试剂盒), suggesting their roles in further regulation of the pluripotent state of ESCs (显示 NR2E3 ELISA试剂盒).
NF90-NF45 (显示 ILF2 ELISA试剂盒) complex induces centronuclear myopathy through increased dynamin 2 (显示 DNM2 ELISA试剂盒) expression by an NF90-NF45 (显示 ILF2 ELISA试剂盒)-induced reduction of miR (显示 MLXIP ELISA试剂盒)-133a expression in vivo.
This work allows to establish a link between Ilf3 and NF90 functions, as RNA binding proteins, and their interacting partners implicated in these functions.
High expression of nuclear factor 90 leads to mitochondrial degradation in skeletal and cardiac muscles through a negative regulation of ribosomes via interaction with ribosomal factors.
cloning of human NF90
characterization of NFAR-1 and NFAR-2 splice forms in human sample
NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD (显示 MYOD1 ELISA试剂盒) and p21WAF1/CIP1 mRNAs
ADAR1 (显示 ADAR ELISA试剂盒) has the potential both to change information content through editing of mRNA and to regulate gene expression through interacting with NF90
NF90 regulates inducible IL-2 (显示 IL2 ELISA试剂盒) gene expression in T cells.
Studies suggest a two-component model for the binding of CBTF with gata2 (显示 GATA2 ELISA试剂盒) promoter, requiring both a CCAAT and A-form DNA, and the double stranded RNA binding domains (dsRBDs) of CBTF component Xilf3 must be active for both binding to the promoter.
Reprot a coordinated regulation of circRNA biogenesis and function by NF90/NF110 in viral infection.
The NF90 regulates PARP1 (显示 PARP1 ELISA试剂盒) mRNA stability in hepatocellular carcinoma cells, and NF90 is a potential target to inhibit PARP1 (显示 PARP1 ELISA试剂盒) activity.
Variants in ILF3 gene is associated with thrombosis.
these data establish miR (显示 MLXIP ELISA试剂盒)-590-5p as an anti-onco-miR (显示 MLXIP ELISA试剂盒) that inhibits colorectal cancer angiogenesis and metastasis through a new mechanism involving NF90/VEGFA (显示 VEGFA ELISA试剂盒) signaling axis.
The data suggest that features of both the N- and C-termini of NF90 participate in the heterodimerization with NF45 (显示 ILF2 ELISA试剂盒) and that the formation of NF90-NF45 (显示 ILF2 ELISA试剂盒) changes the conformation of NF90's RNA-binding motifs to a status in which the co-operative interplay of the RNA-binding motifs is optimal.
NF90-NF45 (显示 ILF2 ELISA试剂盒) stimulates an elevation of EGF receptor (显示 EGFR ELISA试剂盒) levels via the suppression of miR-7 (显示 LILRB1 ELISA试剂盒) biogenesis, resulting in the promotion of cell proliferation in Hepatocellular Carcinoma.
NF90 exerts its antiviral activity by antagonizing the inhibitory role of NS1 (显示 PTPN11 ELISA试剂盒) on PKR (显示 PKLR ELISA试剂盒) phosphorylation
Deletion of the RNA binding domains of NF45 (显示 ILF2 ELISA试剂盒) and NF90 diminished the enhancement of HIV infection and gene expression.
These data suggest that, like ADAR2 (显示 ADARB1 ELISA试剂盒), underlying sequences in dsRNA may influence how NF90 recognizes its target RNAs
The NF90 C-terminus is involved in conformational changes in the protein after RNA binding.
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT)\; a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth\; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
M phase phosphoprotein 4
, interleukin enhancer-binding factor 3
, nuclear factor 90
, nuclear factor associated with dsRNA
, CCAAT box transcription factor p122 subunit
, CCAAT box transcription factor subunit
, Double-stranded RNA-binding protein 4F.1
, dsRNA-binding protein 4F.1
, interleukin enhancer-binding factor 3-A
, M-phase phosphoprotein 4
, double-stranded RNA-binding protein, 76 kD
, dsRNA binding protein NFAR-2/MPP4
, nuclear factor of activated T-cells 90 kDa
, nuclear factor of activated T-cells, 90 kD
, translational control protein 80
, interleukin enhancer binding factor 3, 90kDa
, interleukin enhancer-binding factor 3 homolog