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anti-PTEN (PTEN) 抗体产品概述

Full name:
anti-Phosphatase and Tensin Homolog 抗体 (PTEN)
在www.antibodies-online.cn可供0 Phosphatase and Tensin Homolog (PTEN) 抗体的不同的供货商。 总共0 PTEN产品已列进来了。
10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, GLM2, MHAM, Mmac, MMAC1, PTEN1, PTENP1, TEP1
列出全部抗体 基因 基因ID UniProt
小鼠 PTEN PTEN 19211 O08586
大鼠 PTEN PTEN 50557  
 PTEN PTEN 5728 P60484



Mouse (Murine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. Inhibition of PLK1 (显示 PLK1 抗体) activity or overexpression of a non-phosphorylatable PLK1 (显示 PLK1 抗体) mutant reduces the polyploid cell population.

  2. These findings demonstrate an important role for Pten in maintenance of airway epithelial phenotype integrity.

  3. Data indicate that hydrogen sulfide (显示 SQRDL 抗体) H(2)S inhibits Abeta (显示 APP 抗体)-induced neuronal apoptosis by attenuating mitochondrial translocation of phosphatase and tensin (显示 TNS1 抗体) homologs deleted on chromosome 10 and that activation of PI3K/AKT (显示 AKT1 抗体) signaling pathway plays a critical role in H(2)S-mediated neuronal protection. Our findings provide a novel route into the molecular mechanisms of neuronal apoptosis in Alzheimer's disease.

  4. miR (显示 MLXIP 抗体)-217inhibition can protectively antagonize high glucose-induced podocyte damage and insulin (显示 INS 抗体) resistance by restoring the defective autophagy pathway via targeting PTEN

  5. that Pten, through the Dlg1 (显示 DLG1 抗体)-binding ability of its PDZ (显示 INADL 抗体)-binding domain , accumulates phosphorylated Eg5 (显示 KIF11 抗体) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes

  6. PTEN mediates hepatic macrophage activation in liver fibrosis.

  7. miR (显示 MLXIP 抗体)-718 modulates PI3K/Akt (显示 AKT1 抗体) signaling by directly down-regulating phosphatase and tensin homolog (PTEN), thereby promoting phosphorylation of Akt (显示 AKT1 抗体), which leads to a decrease in proinflammatory cytokine production.

  8. Downregulated miR (显示 MLXIP 抗体)-152 induced impaired hepatic glycogenesis by targeting PTEN. PTEN participated in miR (显示 MLXIP 抗体)-152-mediated glycogenesis in hepatocytes via regulation of the AKT (显示 AKT1 抗体)/GSK pathway

  9. The findings of this study suggest that deletion of Pten in the brain results in impaired bone mass and mineralization, which may contribute to weaker bones and thereby a higher fracture risk.

  10. phenotypic and genetic changes within the pre-neoplastic mammary epithelium of mice with and without stromal PTEN expression

Human Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. The miR (显示 MLXIP 抗体)-19b-PTEN signaling pathway may serve as a novel therapeutic target in the context of ventilator-associated lung fibrosis.

  2. Results show that MiR (显示 MLXIP 抗体)-20b binds to the 3'-UTR (显示 UTS2R 抗体) of PTEN and their expression inversely correlates in esophageal cancer and cells.

  3. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (显示 AKT1 抗体). As well as defining a novel mechanism of Akt (显示 AKT1 抗体) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (显示 FGFR2 抗体), Plc11 and Grb2 (显示 GRB2 抗体) correlate with patient survival

  4. Inhibition of PLK1 (显示 PLK1 抗体) activity or overexpression of a non-phosphorylatable PLK1 (显示 PLK1 抗体) mutant reduces the polyploid cell population.

  5. In perspective of the crucial role PTEN plays in balancing proliferation and apoptosis, we propose PTEN as a valuable marker in the diagnosis, assessment of tumor grade, and disease stage in hepatocellular carcinoma patients

  6. PTEN nuclear expression increased with increasing mitotic rate in gastrointestinal stromal tumors.

  7. our findings demonstrated that dysregulation of miR (显示 MLXIP 抗体)-19a plays critical roles in the osteosarcoma stem cells, at least in part via targeting the phosphatase and tensin homolog (PTEN) deleted on chromosome 10. Knockdown of miR (显示 MLXIP 抗体)-19a may represent a potential strategy for the osteosarcoma treatment.

  8. our data suggest that microRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN

  9. Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer have been presented.

  10. we demonstrate that HOTAIR downregulates miR (显示 MLXIP 抗体)-29b expression and attenuates its control on epigenetic regulation, leading to enhanced PTEN methylation, which contributes to the progression of liver fibrosis.

Pig (Porcine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN, FOXO3A (显示 FOXO3 抗体) and PKB (显示 AKT1 抗体) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

Cow (Bovine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. the miR-17-92 cluster is involved in granulosa cell proliferation and differentiation by coordinately targeting the PTEN and BMPR2 (显示 BMPR2 抗体) genes.

  2. miR (显示 MYLIP 抗体)-26b participates in the inflammatory response of LPS (显示 IRF6 抗体)-stimulated bAMs by modulating the NF-kappaB (显示 NFKB1 抗体) pathway through targeting PTEN.

  3. Pten expression levels in the mammary glands of dairy cows, was investigated.

  4. These studies identify a key role for PTEN in the modulation of lipid mediators involved in adenosine diphosphate receptor-regulated endothelial signaling pathways involving eNOS (显示 NOS3 抗体) activation in vascular endothelial cells.

  5. Overexpressing PTEN enhanced fatty acid oxidation and assembly and secretion of VLDL in cultured hepatocytes.

  6. Inhibition of PTEN activity had no effect on cyclic strain-mediated cell proliferation but inhibited cyclic strain-mediated suppression of apoptosis

Xenopus laevis Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (显示 DVL2 抗体).

  2. PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent.

  3. PTEN-dependent slowing of axonal growth enables the establishment of stable nerve-muscle contacts that develop into neuromuscular junctions.

PTEN 抗原简介

Antigen Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

  • phosphatase and tensin homolog (Pten) 抗体
  • phosphatase and tensin homolog (PTEN) 抗体
  • phosphatase and tensin homolog (pten) 抗体
  • 10q23del 抗体
  • 2310035O07Rik 抗体
  • A130070J02Rik 抗体
  • AI463227 抗体
  • B430203M17Rik 抗体
  • BZS 抗体
  • CWS1 抗体
  • DEC 抗体
  • GLM2 抗体
  • MHAM 抗体
  • Mmac 抗体
  • MMAC1 抗体
  • PTEN1 抗体
  • PTENP1 抗体
  • TEP1 抗体

Protein level used designations for PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten

19211 Mus musculus
50557 Rattus norvegicus
423675 Gallus gallus
5728 Homo sapiens
403832 Canis lupus familiaris
100156264 Sus scrofa
540786 Bos taurus
399142 Xenopus laevis