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anti-PTEN (PTEN) 抗体产品概述

Full name:
anti-Phosphatase and Tensin Homolog 抗体 (PTEN)
在www.antibodies-online.cn可供0 Phosphatase and Tensin Homolog (PTEN) 抗体的不同的供货商。 总共0 PTEN产品已列进来了。
10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, GLM2, MHAM, Mmac, MMAC1, PTEN1, PTENP1, TEP1
列出全部抗体 基因 基因ID UniProt
小鼠 PTEN PTEN 19211 O08586
大鼠 PTEN PTEN 50557  
 PTEN PTEN 5728 P60484



Mouse (Murine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. phenotypic and genetic changes within the pre-neoplastic mammary epithelium of mice with and without stromal PTEN expression

  2. Data suggest that expression, processing, and activation of (that is, signal transduction via) Notch1 (neurogenic locus notch homolog protein 1 (显示 NOTCH1 抗体)), Pten (phosphatase and tensin homolog), and Akt1 (thymoma viral proto-oncogene 1) are involved in oogenesis; oogenesis proceeds via both recruitment of primordial follicles and proliferation of granulosa cells.

  3. this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK (显示 PBK 抗体)/PTEN/Akt (显示 AKT1 抗体) signaling pathway

  4. miR (显示 MLXIP 抗体)-21 overexpression contributes to liver regeneration and hepatocyte proliferation by targeting PTEN

  5. Liver-specific deletion of PTEN significantly ameliorates chronic ethanol-induced increases in hepatocellular damage.

  6. Immunofluorescence studies revealed the abnormal sprouting of mossy fibers in the DG of the Pten-cKO mice prior to the onset of seizures.

  7. Data suggest that reactive oxygen species (ROS (显示 ROS1 抗体))-induced DNA damage results in hypomethylation of the PTEN promoter, upregulation of PTEN mRNA and protein, and a subsequent increase in apoptosis in irradiated lung tissue.

  8. Weight and metformin did not affect the severity of EH resulting from PTEN inactivation

  9. TNF-alpha (显示 TNF 抗体) induces vascular insulin (显示 INS 抗体) resistance by mechanisms that involve positive modulation of PTEN and inhibition of Akt (显示 AKT1 抗体)/eNOS (显示 NOS3 抗体)/NO signaling.

  10. In summary, our study illustrates the potential signal transduction process of PTEN while stimulated by LPS (显示 TLR4 抗体): by increasing the association of TLR4 (显示 TLR4 抗体), PTEN recruits to its phosphoinositide substrate PI(3,4,5)P3 located on the cell membrane and exerts its dephosphorylated function and subsequently depresses the activity of downstream molecule Akt (显示 AKT1 抗体) and results in activation of NF-kappaB (显示 NFKB1 抗体), followed by the secretion of inflamma...

Human Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. Transcript level expression of PTEN was analyzed by reverse transcriptase PCR and quantitative PCR in 20 GBC and 20 GSD tissue samples.

  2. The higher levels of pten mRNA expression post treatment confirmed its role in effective clearance of Leishmania.

  3. we demonstrate that PKCepsilon (显示 PRKCE 抗体) cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCe (显示 PRKCE 抗体) overexpression and Pten loss individually and synergistically upregulate the production of the chemokine (显示 CCL1 抗体) CXCL13 (显示 CXCL13 抗体), which involves the transcriptional activation of the CXCL13 (显示 CXCL13 抗体) gene

  4. PTEN inhibits the occurrence and development of endometriosis by regulating angiogenesis and the apoptosis and cell cycle of endometrial cells.

  5. findings shed new light on the NF-kappaB (显示 NFKB1 抗体)/miR (显示 MLXIP 抗体)-130a/PTEN pathway in cervical cancer and add new insight regarding the carcinogenesis of cervical cancer.

  6. A significantly negative correlation between PTEN and hTERT gene expression indicates that hTERT activation and upregulation may be conferred by the loss of PTEN gene expression in hepatocellular carcinoma (HCC (显示 FAM126A 抗体)).

  7. Loss of PTEN, expression and cyclin D1 (显示 CCND1 抗体) overexpression was seen in a significant number of well differentiated endometrial adenocarcinomas and complex hyperplasias with atypia, suggesting both as an early event in endometrial carcinogenesis.

  8. Hepatitis C virus (HCV) proteins could modulate PTEN by activating NF-kappaB (显示 NFKB1 抗体).

  9. These results may provide a linkage between PCa (显示 FLVCR1 抗体) chemoresistance and exosome regulatory networks and thus lead us to propose that AR, PTEN and TCF4 (显示 TCF4 抗体) genes may be the important genes which are regulated by exosome miRNAs in chemoresistance cancer cells.

  10. This review will summarize the biological roles of phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog in breast cancer, with an emphasis on recent findings and the potential of phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as a therapeutic target for breast cancer therapy.

Pig (Porcine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN, FOXO3A (显示 FOXO3 抗体) and PKB (显示 AKT1 抗体) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

Cow (Bovine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. miR (显示 MYLIP 抗体)-26b participates in the inflammatory response of LPS (显示 IRF6 抗体)-stimulated bAMs by modulating the NF-kappaB (显示 NFKB1 抗体) pathway through targeting PTEN.

  2. Pten expression levels in the mammary glands of dairy cows, was investigated.

  3. These studies identify a key role for PTEN in the modulation of lipid mediators involved in adenosine diphosphate receptor-regulated endothelial signaling pathways involving eNOS (显示 NOS3 抗体) activation in vascular endothelial cells.

  4. Overexpressing PTEN enhanced fatty acid oxidation and assembly and secretion of VLDL in cultured hepatocytes.

  5. Inhibition of PTEN activity had no effect on cyclic strain-mediated cell proliferation but inhibited cyclic strain-mediated suppression of apoptosis

Xenopus laevis Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (显示 DVL2 抗体).

  2. PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent.

  3. PTEN-dependent slowing of axonal growth enables the establishment of stable nerve-muscle contacts that develop into neuromuscular junctions.

PTEN 抗原简介

Antigen Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

  • phosphatase and tensin homolog (Pten) 抗体
  • phosphatase and tensin homolog (PTEN) 抗体
  • phosphatase and tensin homolog (pten) 抗体
  • 10q23del 抗体
  • 2310035O07Rik 抗体
  • A130070J02Rik 抗体
  • AI463227 抗体
  • B430203M17Rik 抗体
  • BZS 抗体
  • CWS1 抗体
  • DEC 抗体
  • GLM2 抗体
  • MHAM 抗体
  • Mmac 抗体
  • MMAC1 抗体
  • PTEN1 抗体
  • PTENP1 抗体
  • TEP1 抗体

Protein level used designations for PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten

19211 Mus musculus
50557 Rattus norvegicus
423675 Gallus gallus
5728 Homo sapiens
403832 Canis lupus familiaris
100156264 Sus scrofa
540786 Bos taurus
399142 Xenopus laevis