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Genetic and biochemical studies of interactions with components of the endocytic machinery suggest that Eps15 has an important role in synaptic vesicle recycling and regulates recruitment of alpha-Adaptin.
Eps-15 controls synaptic vesicle membrane retrieval and synapse development.
Fcho1/2Eps15/RAP-2 (显示 RAP2A ELISA试剂盒) ternary complexes to facilitate conformational activation of AP-2 (显示 GTF3A ELISA试剂盒) by the Fcho1/2 interdomain linker to promote AP-2 (显示 GTF3A ELISA试剂盒) cargo engagement.
An interaction of Eps15 and pS227-FIP2 (显示 OPTN ELISA试剂盒) at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity.
RAB11FIP3 (显示 RAB11FIP3 ELISA试剂盒) combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor (显示 RYK ELISA试剂盒).
Together, the data indicate that a CUL3 (显示 CUL3 ELISA试剂盒)-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 at endosomes.
identify USP9X (显示 USP9X ELISA试剂盒) as a novel regulator of EGFR (显示 EGFR ELISA试剂盒) endocytosis
over-expression of EPS15 is a potential favorable prognostic marker in breast cancer.
MLL (显示 MLL ELISA试剂盒)-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins are associated with acute lymphoblastic leukemia.
Ubiquitin is sufficient for Eps15 recruitment to endosomes.
Results indicate that phosphorylation of epidermal growth factor receptor pathway substrate 15 (Eps15) at Ser (显示 SIGLEC1 ELISA试剂盒)-796 is catalyzed by p38 (显示 CRK ELISA试剂盒) directly.
distinct forms of Eps15 direct EGFR (显示 EGFR ELISA试剂盒) to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S)
Eps15 is a regulator of B-cell lymphopoiesis
a short amino-acid stretch at the carboxy-termini of the monoubiquitinated endocytic proteins Eps15 and eps15R is indispensable for their monoubiquitination
c-Cbl (显示 CBL ELISA试剂盒) directs EGF (显示 EGF ELISA试剂盒) receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15
Our results suggest that spartin (显示 SPG20 ELISA试剂盒) might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.
Mouse hepatitis virus type 2 entry is mediated through clathrin-dependent but Eps15-independent endocytosis
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, Eps15 homologue 1
, epidermal growth factor receptor pathway substrate clone 15
, epidermal growth factor receptor pathway substrate 15
, exopolysaccharide biosynthesis protein, glycosyl transferase
, exopolysaccharide biosynthesis protein, glycosyltransferase
, epidermal growth factor receptor substrate 15-like
, epidermal growth factor receptor substrate 15
, ALL1 fused gene from chromosome 1
, protein AF-1p
, epidermal growth factor pathway substrate 15