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抗Human XRCC1 抗体:
抗Mouse (Murine) XRCC1 抗体:
抗Rat (Rattus) XRCC1 抗体:
Human Monoclonal XRCC1 Primary Antibody for IHC (fro), IHC (p) - ABIN264445
Caldecott, Aoufouchi, Johnson, Shall: XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. in Nucleic acids research 1997
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Human Polyclonal XRCC1 Primary Antibody for ICC, IF - ABIN151964
Iles, Rulten, El-Khamisy, Caldecott: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. in Molecular and cellular biology 2007
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Human Monoclonal XRCC1 Primary Antibody for IHC (p), IP - ABIN180349
Cappelli, Taylor, Cevasco, Abbondandolo, Caldecott, Frosina: Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. in The Journal of biological chemistry 1997
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Human Polyclonal XRCC1 Primary Antibody for FACS, IF - ABIN651735
Lamerdin, Montgomery, Stilwagen, Scheidecker, Tebbs, Brookman, Thompson, Carrano: Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions. in Genomics 1995
Show all 2 references for ABIN651735
no interaction was found between XRCC1 (Arg399Gln) polymorphism genotypes and cadmium exposure in association with nasal polyposis disease
A model has been proposed in which a base excision repair complex containing damaged chromatin is recruited to specific locations in the nuclear matrix for repair, with this recruitment mediated by XRCC1-SNF2H (显示 SMARCA5 抗体) interaction.
This study revealed a positive association of XRCC1 Gln632Gln towards lung cancer, however XRCC1 Arg399Gln, Arg194Trp showed an overall no effect or protective effect.
This study evaluated the influence of genetic polymorphism GSTP1 (显示 GSTP1 抗体) Ile105Val, GSTM1 (显示 GSTM1 抗体) (null/non-null) and 2 XRCC1 polymorphisms (Arg194Trp and Arg399Gln) on the survival of ovarian carcinoma patients treated with chemotherapy. METHODS: 106 patients received treatment with a carboplatin-based or alternative chemotherapy. Polymorphisms were genotyped by pyrosequencing.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (显示 PARP1 抗体) as a therapeutic target in DNA strand break repair-defective disease
Dominant alleles of RAD51 (显示 RAD51 抗体), TP53 (显示 TP53 抗体) and XRCC1 combined genotypes indicated a strong protective role against hereditary breast cancer.
XRCC1 is an HSP90 (显示 HSP90 抗体) client protein that protects XRCC1 from proteasome-mediated degradation.
On stratification according to chemotherapy regimen administered; cisplatin/carboplatin + docetaxel was observed to increase survival for XRCC1 399 mutant genotype (AA) (HR 0.26, p = 0.05).
Chinese Han people with rs1799782 TT/CT genotype of XRCC1 gene may have increased risk of developing colorectal.
The investigation demonstrates that the XRCC1 Arg194Trp polymorphism constitutes a risk factor for thyroid carcinoma in Caucasian individuals (meta-analysis).
We have characterized the nuclear localization signal (NLS (显示 ALDH1A2 抗体)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (显示 OGG1 抗体), Neil1 (显示 NEIL1 抗体), Mutyh (显示 MUTYH 抗体) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (显示 AFG3L2 抗体) serves to recruit XRCC1 that in turn binds and recruits pol beta (显示 POLB 抗体), the primary DNA polymerase (显示 POLB 抗体) of the base excision repair pathway.
Lig4 (显示 LIG4 抗体) and XRCC1 double-deficient cells switch as efficiently as Lig4 (显示 LIG4 抗体)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (显示 LIG1 抗体)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
data reveal that the critical biological role of Lig3 (显示 LIG3 抗体) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair
results establish a role for Lig3 (显示 LIG3 抗体) in mitochondria, but distinguish it from its interacting protein Xrcc1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein