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anti-XRCC1 (XRCC1) 抗体产品概述

Full name:
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 抗体 (XRCC1)
在www.antibodies-online.cn可供126 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) 抗体的20不同的供货商。 再加上,我们可以发XRCC1 蛋白 (6)XRCC1 试剂盒 (3)和数多这个蛋白质的别的产品。 总共142 XRCC1产品已列进来了。
别名:
MGC80909, RCC, Xrcc-1, XRCC1

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引用最多的anti-XRCC1 抗体

  1. Human Monoclonal XRCC1 Primary Antibody for IHC (fro), IHC (p) - ABIN264445 : Caldecott, Aoufouchi, Johnson, Shall: XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. in Nucleic acids research 1997 (PubMed)
    Show all 8 references for ABIN264445

  2. Human Polyclonal XRCC1 Primary Antibody for ICC, IF - ABIN151964 : Iles, Rulten, El-Khamisy, Caldecott: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. in Molecular and cellular biology 2007 (PubMed)
    Show all 3 references for ABIN151964

  3. Human Monoclonal XRCC1 Primary Antibody for IHC (p), IP - ABIN180349 : Cappelli, Taylor, Cevasco, Abbondandolo, Caldecott, Frosina: Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. in The Journal of biological chemistry 1997 (PubMed)
    Show all 2 references for ABIN180349

  4. Human Polyclonal XRCC1 Primary Antibody for FACS, IF - ABIN651735 : Lamerdin, Montgomery, Stilwagen, Scheidecker, Tebbs, Brookman, Thompson, Carrano: Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions. in Genomics 1995 (PubMed)
    Show all 2 references for ABIN651735

更多抗XRCC1的相互作用对抗体

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) interaction partners

  1. the association of six non-synonymous coding variants from XRCC1, XRCC3 (显示 XRCC3 抗体) and XPD (显示 ERCC2 抗体) genes with hepatocellular carcinoma risk, was assessed.

  2. the XRCC1 gene polymorphisms, Arg194Trp and Arg399Gln, are associated with Coronary Artery Disease susceptibility, specifically in Asian populations.

  3. ligase IIIalpha-XRCC1-nucleosome complex decays when ligation is complete, allowing the host nucleosome to return to its native configuration

  4. no interaction was found between XRCC1 (Arg399Gln) polymorphism genotypes and cadmium exposure in association with nasal polyposis disease

  5. A model has been proposed in which a base excision repair complex containing damaged chromatin is recruited to specific locations in the nuclear matrix for repair, with this recruitment mediated by XRCC1-SNF2H (显示 SMARCA5 抗体) interaction.

  6. This study revealed a positive association of XRCC1 Gln632Gln towards lung cancer, however XRCC1 Arg399Gln, Arg194Trp showed an overall no effect or protective effect.

  7. This study evaluated the influence of genetic polymorphism GSTP1 (显示 GSTP1 抗体) Ile105Val, GSTM1 (显示 GSTM1 抗体) (null/non-null) and 2 XRCC1 polymorphisms (Arg194Trp and Arg399Gln) on the survival of ovarian carcinoma patients treated with chemotherapy. METHODS: 106 patients received treatment with a carboplatin-based or alternative chemotherapy. Polymorphisms were genotyped by pyrosequencing.

  8. data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (显示 PARP1 抗体) as a therapeutic target in DNA strand break repair-defective disease

  9. Dominant alleles of RAD51 (显示 RAD51 抗体), TP53 (显示 TP53 抗体) and XRCC1 combined genotypes indicated a strong protective role against hereditary breast cancer.

  10. XRCC1 is an HSP90 (显示 HSP90 抗体) client protein that protects XRCC1 from proteasome-mediated degradation.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) interaction partners

  1. data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (显示 PARP1 抗体) as a therapeutic target in DNA strand break repair-defective disease

  2. We have characterized the nuclear localization signal (NLS (显示 ALDH1A2 抗体)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.

  3. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (显示 OGG1 抗体), Neil1 (显示 NEIL1 抗体), Mutyh (显示 MUTYH 抗体) and Xrcc1 in the brain of adult offspring.

  4. In cells with DNA base damage, PAR (显示 AFG3L2 抗体) serves to recruit XRCC1 that in turn binds and recruits pol beta (显示 POLB 抗体), the primary DNA polymerase (显示 POLB 抗体) of the base excision repair pathway.

  5. Lig4 (显示 LIG4 抗体) and XRCC1 double-deficient cells switch as efficiently as Lig4 (显示 LIG4 抗体)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination

  6. findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (显示 LIG1 抗体)) may contribute more to A-EJ than previously considered

  7. Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

  8. Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.

  9. data reveal that the critical biological role of Lig3 (显示 LIG3 抗体) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair

  10. results establish a role for Lig3 (显示 LIG3 抗体) in mitochondria, but distinguish it from its interacting protein Xrcc1

XRCC1 抗原简介

Antigen Summary

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC1

  • X-ray repair complementing defective repair in Chinese hamster cells 1 (xrcc1) 抗体
  • X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) 抗体
  • X-ray repair complementing defective repair in Chinese hamster cells 1 (Xrcc1) 抗体
  • MGC80909 抗体
  • RCC 抗体
  • Xrcc-1 抗体
  • XRCC1 抗体

Protein level used designations for XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1 , X-ray repair cross complementing protein 1 , DNA repair protein XRCC1-like , DNA repair protein XRCC1 , X-ray repair cross-complementing protein 1 , X-ray-repair, complementing defective, repair in Chinese hamster , x-ray repair cross-complementing group 1 protein

GENE ID SPECIES
446884 Xenopus laevis
456094 Pan troglodytes
476447 Canis lupus familiaris
616905 Bos taurus
711457 Macaca mulatta
100380033 Xenopus (Silurana) tropicalis
100390129 Callithrix jacchus
100458994 Pongo abelii
100469866 Ailuropoda melanoleuca
100519604 Sus scrofa
100580597 Nomascus leucogenys
7515 Homo sapiens
22594 Mus musculus
84495 Rattus norvegicus
100689414 Cricetulus griseus
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