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Study identified a stringent requirement for Mre11 (显示 MRE11A ELISA试剂盒)-Rad50-Nbs (显示 NLRP2 ELISA试剂盒) (MRN) function in telomere protection during early embryonic development.
MRN (Mre11 (显示 MRE11A ELISA试剂盒), Rad50, and Nbs1 (显示 NLRP2 ELISA试剂盒)) complex, CtIP (显示 RBBP8 ELISA试剂盒), and BRCA1 are required for both the removal of Top2 (显示 TOP2 ELISA试剂盒)-DNA adducts and the subsequent resection of Top2 (显示 TOP2 ELISA试剂盒)-adducted DSB ends.
MRN (MRE11 (显示 MRE11A ELISA试剂盒)-RAD50-NBS1 (显示 NLRP2 ELISA试剂盒)) complex has role in ATR (显示 ATR ELISA试剂盒) activation via TOPBP1 (显示 TOPBP1 ELISA试剂盒) recruitment.
Results indicate a role for the X. laevis Mre11 (显示 MRE11A ELISA试剂盒)/Rad50/Nbs1 (显示 NLRP2 ELISA试剂盒) complex in microhomology-mediated end joining.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (显示 ATM ELISA试剂盒) promotes the TopBP1 (显示 TOPBP1 ELISA试剂盒)-dependent activation of ATR (显示 ATR ELISA试剂盒)-ATRIP (显示 ATRIP ELISA试剂盒) in response to double-stranded DNA breaks.
suggests that Mre11 (显示 MRE11A ELISA试剂盒)-Rad50-Nbs1 (显示 NLRP2 ELISA试剂盒) inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.
Data show that the product of the PHS1 (显示 PTGS1 ELISA试剂盒) gene is a cytoplasmic protein that functions by controlling transport of RAD50 from cytoplasm to the nucleus.
The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions.
Mre11 (显示 MRE11A ELISA试剂盒)-Rad50-Nbs1 (显示 NBN ELISA试剂盒) complex initiates DNA double strand break repair.
symmetrical engagement of the Rad50 catalytic head domains with ATP bound at both sites is important for MRN functions in eukaryotic cells.
The results illuminate the important role of Nbs1 (显示 NBN ELISA试剂盒) and CtIP (显示 RBBP8 ELISA试剂盒) in determining the substrates and consequences of human Mre11 (显示 MRE11A ELISA试剂盒)/Rad50 nuclease (显示 DCLRE1C ELISA试剂盒) activities on protein-DNA lesions.
identification of a novel association for longevity in the RAD50/IL13 (显示 IL13 ELISA试剂盒) region on chromosome 5q31.1; the lead SNP rs2706372 is located in the intronic region of the RAD50 gene and is in strong linkage disequilibrium with other associated SNPs close to IL13 (显示 IL13 ELISA试剂盒) and IL5 (显示 IL5 ELISA试剂盒)
the structure of the human Rad50 hook and coiled-coil domains, was determined.
although Mre11 (显示 MRE11A ELISA试剂盒) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (显示 MRE11A ELISA试剂盒) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
The high expression of MRE11 (显示 MRE11A ELISA试剂盒)-RAD50-NBS1 (显示 NBN ELISA试剂盒) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer
Germline mutation in RAD50 gene is associated with familial breast cancer.
The MRN complex is essential to restrain MYCN (显示 MYCN ELISA试剂盒)-induced replication stress during neural cell proliferation.
study identified the copy number deletion of RAD50 as a candidate marker for survival
Low RAD50 expression is associated with B-cell lymphomas.
The authors demonstrate that ATM (显示 ATM ELISA试剂盒) can be activated by DNA double-strand breaks in the absence of the Mre11 (显示 MRE11A ELISA试剂盒)-Rad50-NBS1 (显示 NBN ELISA试剂盒) (MRN) sensor complex.
Rad50 hook domain strongly influences Mre11 (显示 MRE11A ELISA试剂盒) complex-dependent DDR (显示 DDR1 ELISA试剂盒) signaling, tissue homeostasis, and tumorigenesis.
RAD50, DNA-PKcs (显示 PRKDC ELISA试剂盒) kinase activity, and transcription context are each important to limit incorrect end use during EJ repair of multiple DSBs, but each has distinct roles during repair events requiring end processing
Data show that CS-mediated SCC (显示 CYP11A1 ELISA试剂盒) lethality was mitigated in irradiated gain-of-function Rad50(s/s) mice, and epistasis studies order Rad50 upstream of Mre11 (显示 MRE11A ELISA试剂盒).
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
Rad50 mutant mice (Rad50(S/S) mice) exhibited growth defects and cancer predisposition.
the RAD50 LCR has a complex and dual role in Th1 (显示 HAND1 ELISA试剂盒) and Th2 differentiation, communicating early T cell antigen receptor and cytokine signals to the IL-4 (显示 IL4 ELISA试剂盒)/IL-13 (显示 IL13 ELISA试剂盒) locus in both differentiating cell types
enhancer region with four DNase I (显示 DNASE1 ELISA试剂盒) hypersensitive clusters, three of which are highly conserved and predominantly expressed in Th2 cells
The MRE11 (显示 MRE11A ELISA试剂盒)-RAD50-Nijmegen breakage syndrome 1 (NBS1 (显示 NLRP2 ELISA试剂盒) [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
DNA repair protein RAD50
, RAD50 homolog (S. cerevisiae)
, RAD50 homolog
, Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
, Rad50 DNA repair/recombination protein
, DNA repair protein RAD50-like