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抗Human Nibrin 抗体:
抗Mouse (Murine) Nibrin 抗体:
抗Rat (Rattus) Nibrin 抗体:
Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724946
Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. in Molecular carcinogenesis 2011
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Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724942
Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. in Familial cancer 2012
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Human Polyclonal Nibrin Primary Antibody for WB - ABIN361984
Hsu, Shi, Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. in Oncogene 2005
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Human Polyclonal Nibrin Primary Antibody for IHC - ABIN966789
Falck, Coates, Jackson: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. in Nature 2005
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Low NBS1 expression is associated with low-grade epithelial ovarian cancer.
although recruitment of the MRE11 (显示 MRE11A 抗体)-RAD50 (显示 RAD50 抗体)-NBS1 (MRN) DSB-sensing complex to viral genomes and activation of the ATM (显示 ATM 抗体) kinase can promote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of viral DNA.
Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)
Mre11 (显示 MRE11A 抗体)-Rad50 (显示 RAD50 抗体)-Nbs1 complex initiates DNA double strand break repair.
Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.
The results illuminate the important role of Nbs1 and CtIP (显示 RBBP8 抗体) in determining the substrates and consequences of human Mre11 (显示 MRE11A 抗体)/Rad50 (显示 RAD50 抗体) nuclease (显示 DCLRE1C 抗体) activities on protein-DNA lesions.
The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.
The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer
surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination
although Mre11 (显示 MRE11A 抗体) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (显示 MRE11A 抗体) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
the essential role of Nbs1 is via its interaction with Mre11 (显示 MRE11A 抗体) and that most of the Nbs1 protein is dispensable for Mre11 (显示 MRE11A 抗体) complex functions and suggest that Mre11 (显示 MRE11A 抗体) and Rad50 (显示 RAD50 抗体) directly activate ATM (显示 ATM 抗体).
Low NBS1 expression is associated with B-cell lymphomas.
findings show that NBS1 is crucial for macrophage function during normal aging
TRIP13 (显示 TRIP13 抗体)-deficient spermatocytes also progress to an H1t (显示 HIST1H1T 抗体)-positive stage if ATM (显示 ATM 抗体) activity is attenuated by hypomorphic mutations in Mre11 (显示 MRE11A 抗体) or Nbs1 or by elimination of the ATM (显示 ATM 抗体)-effector kinase CHK2 (显示 CHEK2 抗体)
In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.
Nbs1 mutants initially accumulate replication intermediate, not DSBs.
This report showed that ATM (显示 ATM 抗体)-Chk2 (显示 CHEK2 抗体)-P53 (显示 TP53 抗体) signaling pathway and the AKT (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.
JNK (显示 MAPK8 抗体) signaling and ATR (显示 ATR 抗体) signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.
Nbn and Atm (显示 ATM 抗体) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
, Nijmegen breakage syndrome 1 (nibrin)
, cell cycle regulatory protein p95
, p95 protein of the MRE11/RAD50 complex
, nijmegen breakage syndrome protein 1 homolog