anti-Nibrin (NBN) 抗体产品概述

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anti-Nibrin 抗体 (NBN)
在www.antibodies-online.cn可供269 Nibrin (NBN) 抗体的26不同的供货商。 再加上,我们可以发Nibrin 试剂盒 (11)Nibrin 蛋白 (7)和数多这个蛋白质的别的产品。 总共299 Nibrin产品已列进来了。
别名:
AT-V1, AT-V2, ATV, im:6911679, NBN, NBS, Nbs1, P95, zgc:194152

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引用最多的anti-Nibrin 抗体

  1. Human Monoclonal Nibrin Primary Antibody for WB - ABIN394539 : Jelonek, Gdowicz-Klosok, Pietrowska, Borkowska, Korfanty, Rzeszowska-Wolny, Widlak: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. in Journal of applied genetics 2010 (PubMed)
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  2. Human Polyclonal Nibrin Primary Antibody for WB - ABIN196714 : Hsu, Shi, Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. in Oncogene 2005 (PubMed)
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  3. Human Polyclonal Nibrin Primary Antibody for WB - ABIN197200 : Falck, Coates, Jackson: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. in Nature 2005 (PubMed)
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  4. Human Polyclonal Nibrin Primary Antibody for FACS, IF - ABIN655721 : Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010 (PubMed)
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  5. Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724942 : Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. in Molecular carcinogenesis 2011 (PubMed)
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  6. Human Polyclonal Nibrin Primary Antibody for ELISA, WB - ABIN1534475 : Varon, Vissinga, Platzer, Cerosaletti, Chrzanowska, Saar, Beckmann, Seemanová, Cooper, Nowak, Stumm, Weemaes, Gatti, Wilson, Digweed, Rosenthal, Sperling, Concannon, Reis: Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. in Cell 1998 (PubMed)
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  7. Human Polyclonal Nibrin Primary Antibody for IF, ELISA - ABIN1531747 : Carney, Maser, Olivares, Davis, Le Beau, Yates, Hays, Morgan, Petrini: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. in Cell 1998 (PubMed)
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  8. Human Polyclonal Nibrin Primary Antibody for EIA, FACS - ABIN953701 : Kavitha, Choudhary, Raghavan, Muniyappa: Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. in Biochemical and biophysical research communications 2010 (PubMed)
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更多抗Nibrin的相互作用对抗体

Human Nibrin (NBN) interaction partners

  1. Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)

  2. Mre11 (显示 MRE11A 抗体)-Rad50 (显示 RAD50 抗体)-Nbs1 complex initiates DNA double strand break repair.

  3. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.

  4. The results illuminate the important role of Nbs1 and CtIP (显示 RBBP8 抗体) in determining the substrates and consequences of human Mre11 (显示 MRE11A 抗体)/Rad50 (显示 RAD50 抗体) nuclease (显示 DCLRE1C 抗体) activities on protein-DNA lesions.

  5. The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.

  6. The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer

  7. surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination

  8. although Mre11 (显示 MRE11A 抗体) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (显示 MRE11A 抗体) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  9. a somatic missense mutation c.1061C>T (p.P354L) in the NBN gene in a patient with CCS (显示 CCS 抗体) lacking an EWSR1 (显示 EWSR1 抗体)-ATF1 (显示 AFT1 抗体) fusion.

  10. The high expression of MRE11 (显示 MRE11A 抗体)-RAD50 (显示 RAD50 抗体)-NBS1 complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

Mouse (Murine) Nibrin (NBN) interaction partners

  1. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.

  2. findings show that NBS1 is crucial for macrophage function during normal aging

  3. TRIP13 (显示 TRIP13 抗体)-deficient spermatocytes also progress to an H1t (显示 HIST1H1T 抗体)-positive stage if ATM (显示 ATM 抗体) activity is attenuated by hypomorphic mutations in Mre11 (显示 MRE11A 抗体) or Nbs1 or by elimination of the ATM (显示 ATM 抗体)-effector kinase CHK2 (显示 CHEK2 抗体)

  4. In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.

  5. Nbs1 mutants initially accumulate replication intermediate, not DSBs.

  6. This report showed that ATM (显示 ATM 抗体)-Chk2 (显示 CHEK2 抗体)-P53 (显示 TP53 抗体) signaling pathway and the AKT (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.

  7. JNK (显示 MAPK8 抗体) signaling and ATR (显示 ATR 抗体) signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.

  8. Nbn and Atm (显示 ATM 抗体) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.

  9. the antagonism and redundancy of ATMIN (显示 ATMIN 抗体) and NBS1 constitute a crucial regulatory mechanism for ATM (显示 ATM 抗体) signaling and function.

  10. Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage.

Nibrin (NBN) 抗原简介

Antigen Summary

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Alternative names and synonyms associated with Nibrin (NBN)

  • nibrin (NBN) 抗体
  • nibrin (nbn) 抗体
  • nibrin (Nbn) 抗体
  • AT-V1 抗体
  • AT-V2 抗体
  • ATV 抗体
  • im:6911679 抗体
  • NBN 抗体
  • NBS 抗体
  • Nbs1 抗体
  • P95 抗体
  • zgc:194152 抗体

Protein level used designations for anti-Nibrin (NBN) 抗体

nibrin , Nijmegen breakage syndrome 1 (nibrin) , cell cycle regulatory protein p95 , p95 protein of the MRE11/RAD50 complex , nijmegen breakage syndrome protein 1 homolog

GENE ID SPECIES
464278 Pan troglodytes
522943 Bos taurus
100480000 Ailuropoda melanoleuca
100526779 Papio anubis
100557161 Anolis carolinensis
100585384 Nomascus leucogenys
4683 Homo sapiens
27354 Mus musculus
85482 Rattus norvegicus
374246 Gallus gallus
100715565 Cavia porcellus
544655 Danio rerio
100172091 Pongo abelii
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