MCM4 (MCM4) ELISA试剂盒产品概述

Full name:
Minichromosome Maintenance Deficient 4 ELISA试剂盒 (MCM4)
在www.antibodies-online.cn可供5 Minichromosome Maintenance Deficient 4 (MCM4) ELISA试剂盒的3不同的供货商。 再加上,我们可以发MCM4 抗体 (115)MCM4 蛋白 (6)和数多这个蛋白质的别的产品。 总共141 MCM4产品已列进来了。
别名:
19G, AI325074, AU045576, cb1025, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616
list all ELISA KIts 基因 基因ID UniProt
MCM4 4173 P33991
大鼠 MCM4 MCM4 29728  
MCM4 17217 P49717

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MCM4 (MCM4) ELISA试剂盒 by Reactivity

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适于 MCM4 相互作用对的更多 ELISA 试剂盒

Human Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

  1. MCM4 and MCM7 (显示 MCM7 ELISA试剂盒) expression is significantly correlated with Ki-67 (显示 MKI67 ELISA试剂盒), Bmi1 (显示 BMI1 ELISA试剂盒), and cyclin E (显示 CCNE1 ELISA试剂盒) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.

  2. This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.

  3. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin

  4. Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase (显示 DNAH8 ELISA试剂盒) activities to the complex containing wild-type MCM4

  5. Mutant p53 (显示 TP53 ELISA试剂盒) depletion profoundly influenced PARP1 (显示 PARP1 ELISA试剂盒) localization and increased the level of PCNA (显示 PCNA ELISA试剂盒) and MCM4 proteins.

  6. Of the total, the deregulation of several genes (CDK1 (显示 CDK1 ELISA试剂盒), CDK2 (显示 CDK2 ELISA试剂盒), CDK4 (显示 CDK4 ELISA试剂盒), MCM2 (显示 MCM2 ELISA试剂盒), MCM3 (显示 MCM3 ELISA试剂盒), MCM4, EIF3a (显示 EIF6 ELISA试剂盒) and RPN2 (显示 PSMD1 ELISA试剂盒)) were potentially associated with disease development and progression.

  7. Mcm2-7 (显示 MCM2 ELISA试剂盒) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.

  8. Peroxisome proliferator-activated receptor gamma (显示 PPARG ELISA试剂盒) coactivator 1beta (PGC-1beta (显示 PPARGC1B ELISA试剂盒)) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells

  9. point mutation of MCM4 perturbs proper interaction with MCM6 (显示 MCM6 ELISA试剂盒) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (显示 MCM2 ELISA试剂盒) complex

  10. Mutations in MCM4/PRKDC (显示 PRKDC ELISA试剂盒) represent a novel cause of DNA breakage and NK cell deficiency.

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

  1. Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.

  2. Peroxisome proliferator-activated receptor gamma (显示 PPARG ELISA试剂盒) coactivator 1beta (PGC-1beta (显示 PPARGC1B ELISA试剂盒)) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells

  3. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency

  4. MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency

  5. role of subunits in DNA helicase acdtivity

  6. Substrate preference and helicase (显示 DNA2 ELISA试剂盒) actions of mouse MCM4/6/7 helicase (显示 DNA2 ELISA试剂盒) complexes.

  7. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin

  8. Hypomorphic alleles of Mcm4 may increase breast cancer risk.

  9. Loss of one allele of cdc2l (显示 CDK13 ELISA试剂盒) genefacilitates carcinogen-induced skin carcinogenesis in vivo.

  10. Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (显示 MCM2 ELISA试剂盒) complex, causing impaired DNA replication and may have a causative role in cancer development.

MCM4 抗原简介

Antigen Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Alternative names and synonyms associated with MCM4

  • minichromosome maintenance complex component 4 (mcm4) Elisa Kit
  • MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) (mcm4) Elisa Kit
  • minichromosome maintenance complex component 4 (MCM4) Elisa Kit
  • minichromosome maintenance complex component 4 (Mcm4) Elisa Kit
  • minichromosome maintenance deficient 4 homolog (S. cerevisiae) (Mcm4) Elisa Kit
  • 19G Elisa Kit
  • AI325074 Elisa Kit
  • AU045576 Elisa Kit
  • cb1025 Elisa Kit
  • Cdc21 Elisa Kit
  • CDC54 Elisa Kit
  • fc12c09 Elisa Kit
  • fj85g09 Elisa Kit
  • hCdc21 Elisa Kit
  • hm:zeh1616 Elisa Kit
  • mcdc21 Elisa Kit
  • Mcmd4 Elisa Kit
  • mKIAA4003 Elisa Kit
  • NKCD Elisa Kit
  • NKGCD Elisa Kit
  • P1-CDC21 Elisa Kit
  • wu:fc12c09 Elisa Kit
  • wu:fj85g09 Elisa Kit
  • zeh1616 Elisa Kit

Protein level used designations for MCM4

DNA replication licensing factor mcm4 , MCM4 minichromosome maintenance deficient 4 , minichromosome maintenance protein 4 , DNA replication licensing factor MCM4 , CDC21 homolog , homolog of S. pombe cell devision cycle 21 , minichromosome maintenance deficient 4 , mini chromosome maintenance deficient 4 homolog , minichromosome maintenance deficient 4 homolog , P1-CDC21

GENE ID SPECIES
448137 Xenopus (Silurana) tropicalis
337598 Danio rerio
4173 Homo sapiens
426764 Gallus gallus
477871 Canis lupus familiaris
504367 Bos taurus
29728 Rattus norvegicus
17217 Mus musculus
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