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Human ABCA1 ELISA Kit for Sandwich ELISA - ABIN414587
Gluba-Brzózka, Michalska-Kasiczak, Franczyk-Skóra, Nocu?, Banach, Rysz: Markers of increased cardiovascular risk in patients with chronic kidney disease. in Lipids in health and disease 2014
Hepatic free cholesterol content was significantly increased in NASH (显示 SAMSN1 ELISA试剂盒) as compared to non-NASH (显示 SAMSN1 ELISA试剂盒) subjects, while ABCA1 and ABCG1 (显示 ABCG1 ELISA试剂盒) protein levels significantly decreased with NASH (显示 SAMSN1 ELISA试剂盒) and fibrosis progression. The relative expression of miR (显示 MLXIP ELISA试剂盒)-33a and miR (显示 MLXIP ELISA试剂盒)-144 correlated inversely with ABCA1 but not with ABCG1 (显示 ABCG1 ELISA试剂盒) protein levels. miR (显示 MLXIP ELISA试剂盒)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (显示 SAMSN1 ELISA试剂盒) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (显示 ABCB6 ELISA试剂盒) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.01). while increased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.05). ABCA1 was uniformly expressed on the cell membrane, cytoplasm, and nucleus of macrophages.
AMPK (显示 PRKAA1 ELISA试剂盒) activates LXRalpha (显示 NR1H3 ELISA试剂盒) and ABCA1 expression in human macrophages
Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (显示 APOA1 ELISA试剂盒) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (显示 HSD11B1 ELISA试剂盒) biogenesis.
there is an NFATc1 (显示 NFATC1 ELISA试剂盒)/ABCA1-dependent mechanism in which local TNF (显示 TNF ELISA试剂盒) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (显示 TNF ELISA试剂盒), TNFR1 (显示 TNFRSF1A ELISA试剂盒), or TNFR2 (显示 TNFRSF1B ELISA试剂盒) serum levels
Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.
Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.
ABCB1 (显示 ABCB1 ELISA试剂盒) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer
ABCA1 mediates ApoA-I (显示 APOA1 ELISA试剂盒) and ApoA-I (显示 APOA1 ELISA试剂盒) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.
our results highlight the importance of the LXR (显示 NR1H3 ELISA试剂盒)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (显示 SCARB1 ELISA试剂盒) or ABCG1 (显示 ABCG1 ELISA试剂盒) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (显示 HSD11B1 ELISA试剂盒) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (显示 PCSK9 ELISA试剂盒) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (显示 APOA1 ELISA试剂盒)/ABCA1-mediated cholesterol efflux without STAT3 (显示 STAT3 ELISA试剂盒) activation can reduce proinflammatory cytokine expression in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (显示 NR1H3 ELISA试剂盒)-ABCA1/ABCG1 (显示 ABCG1 ELISA试剂盒) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (显示 HSD11B1 ELISA试剂盒)-C levels observed in patients receiving both medications
The findings obtained from apoE (显示 APOE ELISA试剂盒)-/- mice provide epigenetic insights into how EZH2 (显示 EZH2 ELISA试剂盒) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (显示 EZH2 ELISA试剂盒) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.
Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.
Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 (显示 ABCG1 ELISA试剂盒) are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase (显示 NOS ELISA试剂盒) activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ARF6 (显示 ARF6 ELISA试剂盒)-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6 (显示 ARF6 ELISA试剂盒)-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1