Protein tyrosine Phosphatase, Receptor Type, O (PTPRO) ELISA试剂盒产品概述

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Protein tyrosine Phosphatase, Receptor Type, O ELISA试剂盒 (PTPRO)
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别名:
D28, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPBK, Ptpn15, PTPoc, PTPphi, PTPROT, PTPU2, R-PTP-O, RPTP-BK
list all ELISA KIts 基因 基因ID UniProt
PTPRO 50677  
PTPRO 19277 E9Q612
PTPRO 5800 Q16827

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适于 Protein tyrosine Phosphatase, Receptor Type, O 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, O (PTPRO) interaction partners

  1. TLR4 (显示 TLR4 ELISA试剂盒) and NF-kappaB (显示 NFKB1 ELISA试剂盒)/p65 (显示 NFkBP65 ELISA试剂盒) phosphorylation was significantly enhanced in PTPRO over-expressing cells, while significantly down-regulated in PTPRO knockout cells. PTPRO plays ital roles in atherosclerosis (AS) via promoting ox-LDL induced oxidative stress and cell apoptosis through TLR4 (显示 TLR4 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway.

  2. PTPRO plays an important role in FH by interacting with TLR4 (显示 TLR4 ELISA试剂盒).

  3. Study show that EphA4 (显示 EPHA4 ELISA试剂盒) is a substrate for PTP-oc in osteoclasts and that the molecular mechanism contributing to the PTP-oc-induced up-regulation of the osteoclast activity in part involves its dephosphorylation and inactivation of the EphA4 (显示 EPHA4 ELISA试剂盒) signaling.

  4. PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment.

  5. The loss of PTPRO in the tumor niche was correlated with larger tumor volume, more metastases, increased number of circulating tumor cells, less apoptosis and reduced necrosis rates in the orthotopic mouse model of breast cancer.

  6. PTPRO regulates insulin (显示 INS ELISA试剂盒) and lipid metabolism via the PI3K/Akt (显示 AKT1 ELISA试剂盒)/MDM4 (显示 MDM4 ELISA试剂盒)/MDM2 (显示 MDM2 ELISA试剂盒)/P53 (显示 TP53 ELISA试剂盒) axis by affecting autophagy.

  7. Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-kappaB ac (显示 CTNNB1 ELISA试剂盒)tivation.

  8. PTPRO deficiency resulted in reduction of NF-kappaB activation in both hepatocytes and macrophages and was correlated to c-Src phosphorylation.

  9. PTPRO is expressed mainly in TrkB (显示 NTRK2 ELISA试剂盒)-expressing (TrkB (显示 NTRK2 ELISA试剂盒)(+)) and Ret (显示 RET ELISA试剂盒)(+) mechanoreceptors within the trigeminal ganglia during embryogenesis.

  10. These results suggest that ptpro is a target gene of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling and that PTPRO may function as a novel receptor for Wnt (显示 WNT2 ELISA试剂盒).

Human Protein tyrosine Phosphatase, Receptor Type, O (PTPRO) interaction partners

  1. Results provide evidence that PTPRO inhibits ERBB2 (显示 ERBB2 ELISA试剂盒)-driven breast cancer through dephosphorylation leading to dual effects of ERBB2 (显示 ERBB2 ELISA试剂盒) signaling suppression and endosomal internalization of ERBB2 (显示 ERBB2 ELISA试剂盒).

  2. PTPRO is a novel candidate gene in emphysema with severe airflow obstruction.

  3. PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment.

  4. These observations confirm that PTPRO plays a critical role in liver fibrogenesis by affecting PDGF (显示 PDGFA ELISA试剂盒) signaling in HSC (显示 FUT1 ELISA试剂盒) activation and might be developed into a feasible therapeutic approach for the treatment of chronic fibrotic liver diseases.

  5. The optimal pH value of PTP-oc is approximately 7.0.

  6. Loss of PTPRO expression is associated with chronic lymphocytic leukemia.

  7. Results highlight the PTPRO contribution in negative regulation of SRC (显示 SRC ELISA试剂盒)/EGFR (显示 EGFR ELISA试剂盒) signaling in colon cancer.

  8. PTPRO was drastically decreased in fulminant hepatitis, and this was associated with enhanced beta-catenin (显示 CTNNB1 ELISA试剂盒) accumulation but reduced IFN-gamma (显示 IFNG ELISA试剂盒) secretion.

  9. Our study suggests an interesting PTPRO/TLR4 (显示 TLR4 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling feedback loop in Hhepatocellular carcinomcarcinogenesis and progression

  10. PTPRO level was decreased in the early phase but reversed in the late phase of hepatic ischemia reperfusion injury.

Protein tyrosine Phosphatase, Receptor Type, O (PTPRO) 抗原简介

Antigen Summary

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.

Alternative names and synonyms associated with Protein tyrosine Phosphatase, Receptor Type, O (PTPRO)

  • receptor-type tyrosine-protein phosphatase-like (PTP) Elisa Kit
  • protein tyrosine phosphatase, receptor type, O (Ptpro) Elisa Kit
  • protein tyrosine phosphatase, receptor type, O (PTPRO) Elisa Kit
  • D28 Elisa Kit
  • GLEPP1 Elisa Kit
  • NPHS6 Elisa Kit
  • PTP-OC Elisa Kit
  • PTP-U2 Elisa Kit
  • PTPBK Elisa Kit
  • Ptpn15 Elisa Kit
  • PTPoc Elisa Kit
  • PTPphi Elisa Kit
  • PTPROT Elisa Kit
  • PTPU2 Elisa Kit
  • R-PTP-O Elisa Kit
  • RPTP-BK Elisa Kit

Protein level used designations for PTPRO

glomerular epithelial protein 1 , osteoclastic phosphotyrosyl phosphatase , Glomerular epithelial protein 1 , receptor-type protein tyrosine phosphatase D30 , receptor-type tyrosine-protein phosphatase O , PTPase U2 , protein tyrosine phosphatase U2 , protein tyrosine phosphatase, non-receptor type 15 , receptor protein tyrosine phosphatase RO , PTP phi , osteoclastic transmembrane protein-tyrosine phosphatase , phosphotyrosine phosphatase U2 , protein tyrosine phosphatase PTP-U2

GENE ID SPECIES
100009529 Oryctolagus cuniculus
50677 Rattus norvegicus
19277 Mus musculus
5800 Homo sapiens
100714951 Cavia porcellus
100524563 Sus scrofa
486664 Canis lupus familiaris
541043 Bos taurus
373911 Gallus gallus
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