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Nectin (显示 PVRL1 抗体)-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (显示 AMICA1 抗体) (JAM (显示 F11R 抗体))-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 (显示 PVRL3 抗体) and JAM (显示 F11R 抗体)-based cell-cell adhesion sites to form AJ- and TJ-like domains.
NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation.
Findings clearly reveal the structural basis for the cis (显示 CISH 抗体)-dimerization of nectins through the first Ig-like domains.
A link might exist between NECL1 and the extracellular matrix protein OPN (显示 SPP1 抗体) in inhibiting the migration and invasion of U251 glioma ce
NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis.
Nec- 1 (显示 PCSK1 抗体) suppress the growth and tumorigenic ability of colon cancer cells.
Necl-1 is a neural-tissue-specific Ca2 (显示 CA2 抗体)+-independent immunoglobulin-like cell-cell adhesion molecule (显示 PCDHB16 抗体) which potentially has membrane-associated guanylate kinase (显示 GUK1 抗体) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
crystallographic analysis of human Nectin (显示 PVRL1 抗体)-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule (显示 PCDHB16 抗体)
human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS
Expression of entry receptors nectin-1 (显示 PVRL1 抗体) and HVEM (显示 TNFRSF14 抗体) prevent entry of HSV-1 into human conjunctival epithelium.
Necl-1 is a neural-tissue-specific Ca2 (显示 CA2 抗体)+-independent immunoglobulin-like cell-cell adhesion molecule (显示 PCDHb5 抗体) which potentially has membrane-associated guanylate kinase (显示 GUK1 抗体) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.
finding suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3\; MIM 607147) (Kakunaga et al., 2005
, TSLC1-like protein 1
, brain immunoglobulin receptor
, dendritic cell nectin-like protein 1 short isoform
, immunoglobulin superfamily member 4B
, immunoglobulin superfamily, member 4B
, nectin-like 1
, nectin-like protein 1
, synaptic cell adhesion molecule 3
, nectin-lke 1