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Human Polyclonal LTB4R2 Primary Antibody for IF (p), IHC (p) - ABIN748643
Zinn, Sisignano, Kern, Pierre, Tunaru, Jordan, Suo, Treutlein, Angioni, Ferreiros, Leffler, DeBruin, Offermanns, Geisslinger, Scholich: The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. in The Journal of biological chemistry 2017
Human Polyclonal LTB4R2 Primary Antibody for FACS, IHC (p) - ABIN1049031
Bäck, Bu, Bränström, Sheikine, Yan, Hansson: Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. in Proceedings of the National Academy of Sciences of the United States of America 2005
Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor
RanBPM acts as a negative regulator of BLT2 and IL8 (显示 IL8 抗体), thus attenuating the invasiveness of aggressive breast cancer cells
BLT2 inhibition induces apoptosis, inhibits proliferation, colony formation and self-renewal capacity of CD34 (显示 CD34 抗体)(+) cells from tyrosine kinase (显示 TXK 抗体) inhibitor - resistant blast phase-chronic myeloid leukemia (显示 BCL11A 抗体) patients.
Data show that signal transducer and activator of transcription-3 (STAT-3 (显示 STAT3 抗体)) activation occurs downstream of leukotriene B4 receptor-2 (BLT2) and mediates cisplatin resistance in SK-OV-3 cells.
Authors demonstrated that MyD88 (显示 MYD88 抗体) lies upstream of BLT2 in LPS (显示 IRF6 抗体)-potentiated invasiveness and that this 'MyD88 (显示 MYD88 抗体)-BLT2' cascade mediates activation of NF-kappaB (显示 NFKB1 抗体) and the synthesis of IL-6 (显示 IL6 抗体) and IL-8 (显示 IL8 抗体) critical for the invasiveness and aggression of breast cancer cells.
BLT1 and BLT2 are therefore potential targets for the development of novel drugs.
searched BLT2 downstream components and identified reactive oxygen species and nuclear factor kappaB as critical components that contribute to epithelial-mesenchymal transition in mammary epithelial cells
BLT2-NOX-ROS (显示 ROS1 抗体)-NF-kappaB (显示 NFKB1 抗体) cascade induction during detachment confers a novel mechanism of anoikis resistance in prostate cancer cells and potentially contributes to prostate cancer progression.
RanBPM acts as a negative regulator of BLT2 signaling to attenuate BLT2-mediated cell motility
Findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4 (显示 CD4 抗体)(+) T cells may contribute to the pathophysiology of asthma.
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (显示 TLR4 抗体) signaling for IL-13 (显示 IL13 抗体) synthesis in mast cells, thereby potentially exacerbating allergic response.
This study demonstrates that LTB4 (显示 PTGR1 抗体) promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma.
These results show that 12-HHT (显示 ACVRL1 抗体)/BLT2 enhances epithelial barrier function by increasing CLDN4 (显示 CLDN4 抗体) expression via the Galphai protein-p38 MAPK (显示 MAPK14 抗体) pathway.
Data indicate that leukotriene B4 receptor 2 protein BLT2-deficient mice exhibited impaired re-epithelialization and delayed wound closure after skin punching.
Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3 (显示 STAT3 抗体))-dependent up-regulation of matrix metalloproteinase 2 (显示 MMP2 抗体)
Selective inhibition of the BLT2 receptor in mice reduces the release of vascular reactive oxygen species and improves endothelial function in mice
Results suggest a direct anti-inflammatory role of BLT2 that is distinct from the proinflammatory roles of BLT1.
our results suggest that the BLT2-Nox1 (显示 NOX1 抗体)-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs
mouse homolog is a chemoattractant for myeloid leukocytes
leukotriene B4 receptor 2
, LTB4 receptor JULF2
, leukotriene B4 receptor BLT2
, seven transmembrane receptor BLTR2
, LTB4-R 2