anti-PARP1 (PARP1) 抗体产品概述

Full name:
anti-Poly (ADP-Ribose) Polymerase 1 抗体 (PARP1)
在www.antibodies-online.cn可供424 Poly (ADP-Ribose) Polymerase 1 (PARP1) 抗体的27不同的供货商。 再加上,我们可以发PARP1 试剂盒 (39)PARP1 蛋白 (31)和数多这个蛋白质的别的产品。 总共522 PARP1产品已列进来了。
别名:
5830444G22Rik, Adprp, Adprt, ADPRT 1, Adprt1, AI893648, ARTD1, BEST:LD21673, C80510, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, dPARP, LD21673.3prime, padprt-1, parp, parp-1, PARP1, ppol, sPARP-1
列出全部抗体 基因 基因ID UniProt
PARP1 142 P09874
PARP1 25591 P27008
PARP1 11545  

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引用最多的anti-PARP1 抗体

  1. Human Polyclonal PARP1 Primary Antibody for IP, IHC - ABIN2854261 : Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988 (PubMed)
    Show all 8 references for 2854261

  2. Human Polyclonal PARP1 Primary Antibody for ChIP, WB - ABIN2668274 : Kim, Mauro, Gévry, Lis, Kraus: NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. in Cell 2004 (PubMed)
    Show all 5 references for 2668274

  3. Human Monoclonal PARP1 Primary Antibody for IF, WB - ABIN394297 : Lee, Bang, Park, Kim, Shin, Bae: Lack of association between poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population. in Rheumatology international 2012 (PubMed)
    Show all 5 references for 394297

  4. Human Polyclonal PARP1 Primary Antibody for WB - ABIN1881628 : Dong, Bey, Li, Kabbani, Yan, Xie, Hsieh, Gao, Boothman: Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation. in Cancer research 2010 (PubMed)
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  5. Human Polyclonal PARP1 Primary Antibody for WB - ABIN1881627 : Krishnakumar, Kraus: PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. in Molecular cell 2010 (PubMed)
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  6. Human Polyclonal PARP1 Primary Antibody for IF (p), IHC (p) - ABIN677903 : Ma, Liu, Wang, Liu, Chen, Valle, Zuo, Xia, Liu: Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. in ACS nano 2015 (PubMed)
    Show all 2 references for 677903

  7. Human Polyclonal PARP1 Primary Antibody for EIA, WB - ABIN358977 : Tao, Gao, Hoffman, Liu: Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. in Biochemistry 2008 (PubMed)
    Show all 2 references for 358977

  8. Cow (Bovine) Polyclonal PARP1 Primary Antibody for WB - ABIN2778108 : Pétrilli, Herceg, Hassa, Patel, Di Paola, Cortes, Dugo, Filipe, Thiemermann, Hottiger, Cuzzocrea, Wang: Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice. in The Journal of clinical investigation 2004 (PubMed)

更多抗PARP1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.

  2. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (显示 PARK2 抗体) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (显示 PARK2 抗体) mutants.

  3. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (显示 H2AFV 抗体) in a nucleosome positioned in promoter regions of PARP-1-dependent genes

  4. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis

  5. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.

  6. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.

  7. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).

  8. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.

  9. PARP-e autoregulates Parp transcription

  10. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. The NF90 (显示 MMP4 抗体) regulates PARP1 mRNA stability in hepatocellular carcinoma cells, and NF90 (显示 MMP4 抗体) is a potential target to inhibit PARP1 activity.

  2. In response to UV irradiation, DICER (显示 DICER1 抗体) is recruited to chromatin in a ZRF1 (显示 DNAJC2 抗体)-mediated manner. The H2A-ubiquitin binding protein ZRF1 (显示 DNAJC2 抗体) and DICER (显示 DICER1 抗体) together impact on the chromatin conformation via PARP1.

  3. This paper summarises the most significant current literature on the involvement of PARP-1 in gastrointestinal cancer, focusing in particular on its role in the development and occurrence of tumours, providing information about clinical trials and exploring therapeutic possibilities. [review]

  4. PARP-1 stabilizes Sox2 (显示 SOX2 抗体) binding to nucleosomes at suboptimal sites through cooperative interactions on DNA to regulate Sox2 (显示 SOX2 抗体) pioneer activity at intractable genomic loci.

  5. PARP1 can modulate the tumor-suppressing function of HIPK2 (显示 HIPK2 抗体) by regulating the protein stability of HIPK2 (显示 HIPK2 抗体).

  6. HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 and/or Sirt6 (显示 SIRT6 抗体)..physical interaction of HBx and PARP1 accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis

  7. these findings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression.

  8. Elevated PARP (显示 COL11A2 抗体) expression correlated with worse prognosis in early stage breast cancer. [meta-analysis]

  9. study demonstrates that the individual and combined expression patterns of the DDR (显示 DDR1 抗体) molecules PARP1, gammaH2AX (显示 H2AFX 抗体), BRCA1, and BRCA2 (显示 BRCA2 抗体) could be predictive of the prognosis of STS (显示 STS 抗体) patients and suggests that controlling the activity of these DDR (显示 DDR1 抗体) molecules could be employed in new therapeutic stratagems for the treatment of STS (显示 STS 抗体)

  10. PARP1/2 inhibitor simmiparib causes growth inhibition in cancer cell- or tissue-derived xenografts in nude mice.

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected

  2. ADPRT Val762Ala and APE1 (显示 APEX1 抗体) Asp148Glu polymorphisms are not associated with increased breast cancer risk

  3. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites

  4. FGF2 (显示 FGF2 抗体) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (显示 MAPK1 抗体))-dependent pathway

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) interaction partners

  1. The findings suggest that PARP1 inhibition protects against long-term ethanol-induced liver injury, as indicated by limited hepatocytes steatosis, apoptosis, inflammation levels, and neutrophil infiltration, mainly by limiting KC activation during the initiation of ALD.

  2. PARP-1 knockout resulted in lowered arginase II (显示 ARG2 抗体) expression in macrophages and aortic endothelial cells.

  3. PARP-1 stabilizes Sox2 (显示 SOX2 抗体) binding to nucleosomes at suboptimal sites through cooperative interactions on DNA to regulate Sox2 (显示 SOX2 抗体) pioneer activity at intractable genomic loci.

  4. Delayed healing in ischemic and diabetic wounds is caused by PARP hyperactivity, and PARP inhibition significantly enhanced ischemic and diabetic wound healing by promoting angiogenesis.

  5. The findings highlight specific non-overlapping functions of PARP1 and PARP2 (显示 PARP2 抗体) at H2AX (显示 H2AFX 抗体)-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 in nonhomologous end-joining-deficient cells.

  6. data establish the importance of XRCC1 (显示 XRCC1 抗体) protein complexes for normal neurological function and identify PARP1 as a therapeutic target in DNA strand break repair-defective disease

  7. this study shows that PARP-1 inhibition plays role in puerarin-mediated protection from liver fibrosis

  8. might be involved in streptomycin ototoxicity by regulating AIF (显示 AIFM1 抗体) translocation in cochlear hair cells

  9. Nonionizing radiofrequency exposure is capable of inducing PARP-1.

  10. our data suggest that Parp1 is involved in the plastic remodeling of chromatin structure after NT by supporting DNA repair and specific histone code modifications.

PARP1 抗原简介

Antigen Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Alternative names and synonyms associated with PARP1

  • Poly-(ADP-ribose) polymerase (Parp) 抗体
  • poly (ADP-ribose) polymerase 1 (PARP1) 抗体
  • poly (ADP-ribose) polymerase 1 (Parp1) 抗体
  • poly (ADP-ribose) polymerase 1 (parp1) 抗体
  • poly (ADP-ribose) polymerase family, member 1 (Parp1) 抗体
  • poly ADP-ribose polymerase (Parp) 抗体
  • 5830444G22Rik 抗体
  • Adprp 抗体
  • Adprt 抗体
  • ADPRT 1 抗体
  • Adprt1 抗体
  • AI893648 抗体
  • ARTD1 抗体
  • BEST:LD21673 抗体
  • C80510 抗体
  • CG17685 抗体
  • CG17696 抗体
  • CG17718 抗体
  • CG40411 抗体
  • D.PARP 抗体
  • Dm.pARTa 抗体
  • Dmel\\CG40411 抗体
  • dPARP 抗体
  • LD21673.3prime 抗体
  • padprt-1 抗体
  • parp 抗体
  • parp-1 抗体
  • PARP1 抗体
  • ppol 抗体
  • sPARP-1 抗体

Protein level used designations for PARP1

CG40411-PB , CG40411-PC , Parp-PB , Parp-PC , Poly(ADP ribose) polymerase 1 , Poly(ADP)-Ribose polymerase , Poly(ADP-)Ribose polymerase , Poly(ADP-ribose) polymerase , Poly(ADP-ribose) polymerase 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) , ADP-ribosyltransferase NAD(+) , ADP-ribosyltransferase diphtheria toxin-like 1 , NAD(+) ADP-ribosyltransferase 1 , poly (ADP-ribose) polymerase family, member 1 , poly [ADP-ribose] polymerase 1 , poly(ADP-ribose) polymerase , poly(ADP-ribose) synthetase , poly(ADP-ribosyl)transferase , poly[ADP-ribose] synthase 1 , ADP-ribosyltransferase (NAD+ , ADP-ribosyltransferase 1 , ADPRT 1 , poly (ADP-ribose) polymerase) , poly(ADP-ribose) polymerase PARP-1 , poly[ADP-ribose] synthetase 1 , ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase) , PARP-1 , ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1 , msPARP , Poly[ADP-ribose] synthase 1

GENE ID SPECIES
3355109 Drosophila melanogaster
142 Homo sapiens
25591 Rattus norvegicus
286764 Bos taurus
397928 Xenopus laevis
396199 Gallus gallus
490385 Canis lupus familiaris
11545 Mus musculus
100689463 Cricetulus griseus
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