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抗Rat (Rattus) CYLD 抗体:
抗Mouse (Murine) CYLD 抗体:
抗Human CYLD 抗体:
Mouse (Murine) Polyclonal CYLD Primary Antibody for WB - ABIN374832
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. in Cell 2006
Human Polyclonal CYLD Primary Antibody for ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. in Infection and immunity 2010
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (显示 DNMT1 抗体)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (显示 DNMT1 抗体)-linked chains are presented.
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (显示 MYD88 抗体)-mediated signaling by directly interacting with MyD88 (显示 MYD88 抗体) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (显示 MYD88 抗体) at lysine 231.
CYLD interrupts the ERK (显示 EPHB2 抗体)- and p38 (显示 CRK 抗体)-/AP-1 (显示 JUN 抗体) and c-Myc (显示 MYC 抗体) pathways to suppress Nrf2 (显示 NFE2L2 抗体)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Data show that the in utero death of NF-NF (显示 NFASC 抗体)-kappaB (显示 NFKB1 抗体) essential modulator (NEMO (显示 IKBKG 抗体)) and cylindromatosis protein double mutant mice is mediated by TNF (显示 TNF 抗体) receptor 1 (TNFR1 (显示 TNFRSF1A 抗体)) signaling and can be rescued by TNFR1 (显示 TNFRSF1A 抗体) deficiency.
CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (显示 NFKB1 抗体) dependent anti-apoptotic signaling.
In contrast to full-length CYLD, the immune function of short splice variant CYLD (sCYLD) is insufficiently described. To explore sCYLD's function in infection, investigated whether dendritic cell-specific sCYLD regulates the pathogenesis of listeriosis.
The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin (显示 UBB 抗体) chain from centrosomal protein of 70 kDa (Cep70 (显示 CEP70 抗体)), a requirement for Cep70 (显示 CEP70 抗体) to interact with gamma-tubulin (显示 TUBG1 抗体) and localize at the centrosome.
CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (显示 IL8 抗体) expression via MKP-1 (显示 DUSP1 抗体)-dependent inhibition of ERK (显示 EPHB2 抗体).
Low CYLD expression is associated with hepatocellular carcinoma.
miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (显示 NFKB1 抗体) pathway and the downstream targets, livin (显示 BIRC7 抗体) and survivin (显示 BIRC5 抗体), which potentially induced GC chemoresistance.
Data show that cylindromatosis (CYLD) overexpression and livin (显示 BIRC7 抗体) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (显示 BLNK 抗体)) cells.
aberrantly expressed miR (显示 MLXIP 抗体)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer
These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.
Novel CYLD germline mutations c.1821_1826+1delinsCT/L607Ffs*9, c.2666A>T/p.D889V and c.2712delT/p.905Kfs*8 were identified in unrelated Brooke-Spiegler Syndrome patients.
Study founds the levels of CYLD and SMAD7 (显示 SMAD7 抗体) significantly decreased in oral squamous cell carcinoma (OSSC) cells and proposes a model that CYLD suppresses OSCC metastases through SMAD7 (显示 SMAD7 抗体). Downregulation of CYLD appears to directly contribute to the distal metastases of primary OSCC and subsequently poor prognosis.
Haplotype analysis was performed for the patients with multiple familial trichoepithelioma type 1, patients with familial cylindromatosis and a patient with Brooke-Spiegler syndrome, all of whom carry the same heterozygous nonsense CYLD mutation.
Ultraviolet radiation induced CYLD translocation from the cytoplasm to microtubules, posttranslational modification and degradation in a proteasome-independent manner.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, ubiquitin carboxyl-terminal hydrolase CYLD
, deubiquitinating enzyme CYLD
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, retinitis pigmentosa 1 homolog
, ubiquitin specific peptidase like 2