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CD247 抗体 (AA 153-164)

CD247 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 1D4 unconjugated
产品编号 ABIN967517
发货至: 中国
  • 抗原 See all CD247 抗体
    CD247 (CD247 Molecule (CD247))
    抗原表位
    • 13
    • 13
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 153-164
    适用
    • 94
    • 42
    • 18
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 75
    • 16
    • 6
    • 1
    小鼠
    克隆类型
    • 73
    • 25
    单克隆
    标记
    • 56
    • 9
    • 8
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CD247 antibody is un-conjugated
    应用范围
    • 73
    • 53
    • 35
    • 14
    • 11
    • 10
    • 7
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    品牌
    BD Pharmingen™
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human CD3zeta synthetic peptide aa. 153-164
    克隆位点
    1D4
    亚型
    IgG1
    Top Product
    Discover our top product CD247 Primary Antibody
  • 应用备注
    Applications include immunoprecipitation and western blot analysis (1-2 µg/ml). Jurkat T cells (ATCC TIB 152) are suggested as a positive control.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Hall, Sancho, Terhorst: "Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells." in: Science (New York, N.Y.), Vol. 261, Issue 5123, pp. 915-8, (1993) (PubMed).

    Hussey, Clayton, Diener, McConkey, Howard, Rodewald, DAdamio, Dallenbach, Stein, Schmidt: "Overexpression of CD3 eta during thymic development does not alter the negative selection process." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 4, pp. 1183-94, (1993) (PubMed).

    Sancho, Franco, Chatila, Hall, Terhorst: "The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif." in: European journal of immunology, Vol. 23, Issue 7, pp. 1636-42, (1993) (PubMed).

  • 抗原
    CD247 (CD247 Molecule (CD247))
    别名
    CD247 (CD247 产品)
    别名
    CD3-ZETA antibody, CD3H antibody, CD3Q antibody, CD3Z antibody, T3Z antibody, TCRZ antibody, 4930549J05Rik antibody, A430104F18Rik antibody, AW552088 antibody, Cd3 antibody, Cd3-eta antibody, Cd3-zeta antibody, Cd3h antibody, Cd3z antibody, Cd3zeta antibody, T3z antibody, Tcrk antibody, Tcrz antibody, LOC100136514 antibody, LOC100136549 antibody, LOC100305023 antibody, CD247 antibody, TCRzeta antibody, CD247 molecule antibody, CD247 antigen antibody, CD3zeta-2 antibody, CD3zeta-1 antibody, Cd247 molecule antibody, CD247 antibody, Cd247 antibody, cd3z antibody, cd247 antibody
    背景
    The T-cell receptor (TCR), expressed by thymus-derived lymphocytes, is a multicomponent complex responsible for recognizing antigen in the context of MHC molecules. Ti is the antigen-specific binding component of the TCR. On the majority of peripheral T lymphocytes Ti is present as a disulfide-linked alpha-beta heterodimer. A minor fraction express Ti as a gamma-delta heterodimer. The Ti subunits are Ig-like, each containing V and C regions. Ti is noncovalently associated with an invariant set of molecules referred to as the CD3 subunits. CD3 appears early in thymocyte differentiation and remains expressed on all mature T lymphocytes. In the mouse, it consists of five chains, gamma (gamma), delta (delta), epsilon (epsilon), zeta (zeta), and p21. The relative masses of the mouse CD3 chains are 21, 28, 26, 32, (dimer), and 21 kD respectively. 1D4 recognizes human but not mouse CD3zeta. It is most efficient at recognizing the phosphorylated form of CD3zeta (21 kD) but will also bind the 16 kD unphosphorylated monomer as well as higher molecular weight dimers. A synthetic peptide corresponding to amino acids 153 to 164 of human CD3zeta was used as immunogen.
    Synonyms: CD3zeta chain
    分子量
    21 kDa
    途径
    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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