S100A8 抗体 (S100 Calcium Binding Protein A8) (FITC)

Details for Product anti-S100A8 Antibody No. ABIN954653, 供应商: Log in to see
抗原
  • EWWD
  • MRP8
  • WW
  • 60B8AG
  • CAGA
  • CFAG
  • CGLA
  • CP-10
  • L1Ag
  • MA387
  • MIF
  • NIF
  • P8
  • Mrp8
  • S100A8
  • 60B8Ag
  • AI323541
  • B8Ag
  • CFAg
  • Caga
  • p8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 11
  • S100 calcium binding protein A8
  • S100 calcium binding protein A8 (calgranulin A)
  • ABCC11
  • S100A8
  • S100a8
适用

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克隆类型 (克隆位点)
单克隆 ()
标记
This S100A8 antibody is conjugated to FITC
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应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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选项
Supplier
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Supplier Product No.
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免疫原 Purified granulocyte antigen of Human origin.
克隆位点 CF-145
亚型 IgG2b
特异性 This antibody detects Calgranulin A (S100A8).
交叉反应 (详细) Species reactivity (tested):Human.
纯化方法 Protein G Chromatography of Ascitic fluid.
别名 S100A8 / Calgranulin-A / MRP8 (S100A8 Antibody 摘要)
背景 Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma.Synonyms: CAGA, CFAG, Calprotectin L1L subunit, Cystic fibrosis antigen, Leukocyte L1 complex light chain, MRP-8, Migration inhibitory factor-related protein 8, S100 calcium-binding protein A8, S100-A8, Urinary stone protein band A
基因ID 6279
NCBI登录号 NP_002955
UniProt P05109
研究领域 Cell Cycle
途径 Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 0.1 mg/mL
缓冲液 PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
厂商提供的图像
Immunohistochemistry (IHC) image for anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC)
Flow Cytometry (FACS) image for anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (Image 2)
背景 Thacher, Nagpal, Klein, Arefieg, Krasinski, DiSepio, Agarwal, Johnson, Eckert, Chandraratna: "Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 4, pp. 255-62, 1999 (PubMed).

Nagpal, Thacher, Patel, Friant, Malhotra, Shafer, Krasinski, Asano, Teng, Duvic, Chandraratna: "Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 7, Issue 12, pp. 1783-91, 1997 (PubMed).

Klein, Pino, Johnson, Davies, Nagpal, Thacher, Krasinski, Chandraratna: "Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22692-6, 1996 (PubMed).

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