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小鼠 anti-人 IgM (Fc Region) Antibody

ABIN94402 产品详细信息, 供应商: Log in to see
抗原
抗原表位
Fc Region
558
373
290
63
56
51
46
28
6
6
2
1
1
1
1
适用

1191
559
232
92
80
67
66
58
56
56
56
40
35
28
19
15
15
7
5
5
2
1
1
1
宿主
小鼠
1262
665
511
143
38
11
10
9
4
3
3
2
克隆类型 (克隆位点)
单克隆 ()
应用范围
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
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免疫原 Purified human IgM.
克隆位点 CH2
亚型 IgG1
特异性 The antibody CH2 reacts with Fc fragment of human IgM.
纯化方法 Purified from ascites by precipitation methods and ion exchange chromatography.
纯度 > 95 % (by SDS-PAGE)
背景 Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.
分子量 900 kDa
研究领域 Secondary Antibodies
应用备注 Flow Cytometry: Recommended dilution: 1 µg/mL

Working concentrations should be determined by the investigator.
限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
储存液 Sodium azide
注意事项 WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事项 Do not freeze.
储存条件 4 °C
储存方法 Store at 2-8 °C. Do not use after expiration date stamped on vial label.
厂商提供的图像
Flow Cytometry (FACS) image for 小鼠 anti-人 IgM (Fc Region) Antibody (ABIN94402) Surface staining of human peripheral blood cells with anti-human IgM (CH2) APC. Cells...
背景 Brinkmann, Heusser: "T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors." in: Cellular immunology, Vol. 152, Issue 2, pp. 323-32, 1994 (PubMed).

Balogh, Merétey, Falus, Bozsóky: "Serological abnormalities in juvenile chronic arthritis: a review of 46 cases." in: Annals of the rheumatic diseases, Vol. 39, Issue 2, pp. 129-34, 1980 (PubMed).

Franklin: "Structure and function of immunoglobulins." in: Acta endocrinologica. Supplementum, Vol. 194, pp. 77-95, 1975 (PubMed).

Fuller, Keyser: "Serum immunoglobulins after surgical operation." in: Clinical chemistry, Vol. 21, Issue 6, pp. 667-71, 1975 (PubMed).