TAZ 抗体 (AA 386-390)
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- 抗原 See all TAZ 抗体
- TAZ (Tafazzin (TAZ))
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抗原表位
- AA 386-390
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TAZ antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- The antibody detects endogenous level of total TAZ protein.
- 纯化方法
- Affinity purified
- 免疫原
- Peptide sequence around AA 386-390 (V-E-S-A-L) derived from Human TAZ. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Top Product
- Discover our top product TAZ Primary Antibody
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- 应用备注
- Western blotting: 1:500-1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- 抗原
- TAZ (Tafazzin (TAZ))
- 别名
- TAZ (TAZ 产品)
- 别名
- wu:fb39f12 antibody, zgc:91803 antibody, MGC54019 antibody, TAZ antibody, taz antibody, GB11956 antibody, Afu2g13960 antibody, BTHS antibody, CMD3A antibody, EFE antibody, EFE2 antibody, G4.5 antibody, LVNCX antibody, Taz1 antibody, 5031411C02Rik antibody, 9130012G04Rik antibody, AW107266 antibody, AW552613 antibody, tafazzin antibody, tafazzin L homeolog antibody, tafazzin homolog antibody, TAZ antibody, taz antibody, taz.L antibody, LOC550948 antibody, AFUA_2G13960 antibody, AOR_1_318014 antibody, Tsp_06712 antibody, Taz antibody
- 背景
- Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
- 分子量
- 49 kDa
- 基因ID
- 25937
- NCBI登录号
- NP_001161
- UniProt
- Q9GZV5
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